1,006 search results for “bioactive molecules” in the Public website
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Geert-Jan Kroes
Science
g.j.kroes@chem.leidenuniv.nl | +31 71 527 4396
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
- IBL Spotlights
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Physicochemical analysis of allosteric binding pockets
Supervisor: Gerard van Westen
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
- Extracts
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ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Visualising the nanoworld
Visualising cell proteins without invasive techniques is possible with the help of fluorescence. During a lecture of the Natuurwetenschappelijk Gezelschap Leiden on 18 January, winner of the Spinoza Prize 2017 and founder of the field of single molecule optics Michel Orrit explained how this works.
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame
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The mechanical genome : inquiries into the mechanical function of genetic information
The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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DNA expressions - A formal notation for DNA
Promotores: J.N. Kok, H.J. Hoogeboom
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Systematics, biogeography and bioactivity of the genus Phyllanthus L. and related genera of tribe Phyllantheae (Phyllanthaceae)
PhD defence
- Jan van Ruitenbeek Lab - Atomic and Molecular Conductors
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Electroextraction approaches for preconcentration of metabolites
In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.
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Frontiers in surface scattering simulations
Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Marcel Schaaf
Science
m.j.m.schaaf@biology.leidenuniv.nl | +31 71 527 4975
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Unlocking the chemistry of the heavens
How are the building blocks of life formed?
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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Understanding membrane fusion at the molecular level using a biomimetic model system
How can the transport of molecules in living cells help to target medicines at exactly the right place?
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Phylogenetic ecology of octocoral - gastropod associations
Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.
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Key publications
Key publications of the Computational Drug Discovery group
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Michel Orrit receives Spinoza Prize in Royal Theatre
On September 12, Michel Orrit received his Spinoza prize in the Royal Theatre in The Hague from OCW Secretary of State Sander Dekker. With the award comes a budget of 2.5 million euro, to be spent freely on scientific research, and the coveted Spinoza statue. Orrit shared the honor with Eveline Crone…
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Michel Orrit wins Physica Prize 2016
Michel Orrit was awarded the Physica prize 2016 for his groundbreaking work on single molecule spectroscopy.
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Physicist Michel Orrit new member KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit.
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Michel Orrit and Hermen Overkleeft members KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit and chemist Hermen Overkleeft.
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Uncovering the ingredients for planet formation
This thesis discusses the physical and chemical processes than influence the composition of forming planets.
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PhD Theses
A full overview of THEOR PhD theses.
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Chemistry between stars and planets
In the large gas clouds between the stars, chemical reactions take place under extreme conditions, giving rise to both small molecules, such as water and common salt, as well as large complex molecules that can serve as the building blocks of life. This is known as astrochemistry and it is something…
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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New generation of graphene biosensors based on smooth surfaces and sharp edges
The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…
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Elucidating the catalytic properties of gold
How does CO adsorption on gold promote its own oxidation and the oxidation of other organic molecules?
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Reactivity on interstellar ice analogues
The
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Research
Research at the THEOR group is comprised of the following research themes:
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Research
Developing computational algorithms for structural biology -A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve…
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Laboratory studies of Water Ice in Space
Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.
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Data mining and algorithm development
Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…
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NWO grants two IBL-proposals by interdisciplinary research consortia
Recently, NWO has decided to grant two interdisciplinary research proposals for national and international consortia submitted by researchers from the Institute of Biology Leiden. One of the proposals is led by Prof. dr. Ariane Briegel, the other one by dr. Remko Offringa.
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology