Learning about circadian rhythms can help students to improve their sleep and overall well-being

Researchers at LUMC are trying to decipher the biological clock. This knowledge can help deal with luxury problems, such as jetlag, but can also counter diseases. Molecular neurobiologist Erno Vreugdenhil explains.

This year's Nobel Prize for Medicine goes to the three American researchers who have unravelled the mechanism behind the biological clock. Joke Meijer, Professor of Neurophysiology and an expert in the field of the sleep-wake rhythm, explained in Dutch newspapers Trouw and NRC why this discovery is…

During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Dutch researchers are joining forces to conduct research together with a series of societal partners to keep the biological clock healthy in our modern 24-hour society. The BioClock consortium will receive a research grant of no less than 9.7 million euros for this. It is one of the projects that receive…

How distance-dependent is graphene as biological sensor?

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

We study the physics of a broad range of biological and soft materials

Schneider

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.

Three of the four Heineken Young Scientists Awards for 2022 have gone to researchers from Leiden: chronobiologist Laura Kervezee, physicist Jordi Tura i Brugués and health psychologist Liesbeth van Vliet.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Are there acoustic cues for settlement stage larvae in deep-sea soundscapes around hydrothermal vents?

How do nanoparticles bioaccumulate and biodistribute in organisms?

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Promotores: H. Schiessel, G.T. Barkema

Animal Sciences’ contributions to the Evolution & Biodiversity research theme include evo-devo research, the evolution of cognitive and behavioural traits, and the evolutionary mechanisms of stress adaptation. This research involves both indoor and outdoor studies.

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

Proactive zebrafish appear to have a much stronger wake-sleep rhythm than reactive fish. In the most reactive fish, rhythmicity appears to be lacking completely. This is shown with research by Leiden biologists, published in December 2018 in the journal BMC Biology.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

What is vegetation structure and composition in SFM primary forest, secondary logged over forest (logging FSC certified and logging non certified) in comparison to primary forest? What is avian guild diversity in SFM primary forest, secondary logged over forest (logging FSC certified and logging non…

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Do you often find yourself exhausted in the lecture hall or at your workplace? Not great for your mental well-being, as Laura Pape knows. She is investigating how an online self-help program can assist in addressing sleep issues and preventing mental health problems. Join her on this elevator pitch…

Description of The Regional Network on the Synergy between the Convention on Biological Diversity and the UN Convention to Combat Desertification.

The European Research Commission (ERC) has awarded Advanced Grants to two Leiden researchers. Joke Meijer will be researching the effect of the biological clock on our health and Carlo Beenakker will be looking for Majorana fermions in superconductors.

This week the European Court of Justice ruled that companies in the European Union as of now have to register the amount of hours their employees work. Member States will be responsible for ensuring employers establish such registration systems.

LCN2 organizes seminars on the last Friday of each month.

On Friday the 6th of December, the annual symposium of the IBL was organized at the Buruma theatre (LUMC), Leiden. This year’s theme was “Biological Networks from Molecules to Society”.

Using biologically inspired algorithms on 'edge devices', such as cameras and mobile phones, is what Svetlana Minakova's PhD research was all about. She conducted research on Convolutional Neural Networks(CNN). Making these algorithms work in different situations is a complicated task. 'Most design…

In August-September 2016 three CML students are doing an exciting field work in sub-arctic tundra in Sweden in collaboration with Ümea University.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

PhD defence

Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…