403 search results for “chronic pain” in the Public website
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Acute and chronic pain after cardiac surgery
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)
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The QSPainRelief consortium will improve the treatment of chronic pain
The €6.24 million EU-funded research project QSPainRelief has kicked off. The project aims to help patients suffering from chronic pain with novel, personalised combinational treatments and is coordinated by Elizabeth de Lange from the Leiden Academic Center for Drug Research.
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Jessy Terpstra
Faculteit der Sociale Wetenschappen
j.a.terpstra@fsw.leidenuniv.nl | +31 71 527 2727
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Antoinette van Laarhoven
Faculteit der Sociale Wetenschappen
a.vanlaarhoven@fsw.leidenuniv.nl | +31 71 527 6634
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Topic: Persistent physical symptoms
Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…
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Henriët van Middendorp
Faculteit der Sociale Wetenschappen
h.van.middendorp@fsw.leidenuniv.nl | +31 71 527 6333
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Roos van der Vaart
Faculteit der Sociale Wetenschappen
r.van.der.vaart@fsw.leidenuniv.nl | +31 71 527 2727
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Attentional processing of itch and pain
This project is aimed at 1) elucidating the role of attention in itch and pain, including orientation, and attentional disengagement (i.e., directing attention away) from itch and pain; and 2) modifiability of these attentional processes.
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Topic: Psychological factors in Itch and pain
Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…
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Topic: Self-management in chronic diseases
Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…
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e-Coach: Tailored cognitive-behavioral e-Health care for patients with chronic somatic conditions
The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.
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Topic: Stigmatization in patients with chronic health conditions
Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Determinants of and Interventions in Chronic Fatigue.
What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome, and which interventions are effective in influencing these factors?
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Veronique de Gucht
Faculteit der Sociale Wetenschappen
degucht@fsw.leidenuniv.nl | +31 71 527 3863
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Joey Zuijdervelt
Science
j.l.zuijdervelt@lacdr.leidenuniv.nl | +31 71 527 6227
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PhD Candidate Biopsychosocial factors in chronic skin conditions
Social and Behavioural Sciences, Psychology
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Expectations can relieve pain
To relieve a patient's pain, it can be effective to induce expectations. This finding is promising for optimising the effectiveness of treatments, conclude Kaya Peerdeman and colleagues in their article in PAIN.
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The role of expectancies and avoidance learning in the maintenance of somatic symptoms
Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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participation in a hybrid classroom: Interacting with students with chronic illnesses
There are about 35,000 students with chronic illnesses in the Netherlands. If they cannot receive education in the classroom, they may be able to do so from home or a hospital with hybrid education. The question in this study is: how can interaction with the teacher and fellow students be promoted?
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depression and the relation between stress, mental health, ageing and chronic illness
I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.
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The Power and Pains of Polysemy: Maritime Trade, Averages, and Institutional Development in the Low Countries (15th–16th Centuries)
The Power and Pains of Polysemy: Maritime Trade, Averages, and Institutional Development in the Low Countries (15th–16th Centuries) investigates the development of General Average and other so-called Averages in the Low Countries on the eve of the early modern period, showing how the various varieties…
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models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
M. Danhof, Co-promotor: O.E. Della Pasqua
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Research projects
An overview of research projects at the Predictive Pharmacology group.
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Topic: Stress and stress-related disorders
The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…
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Pain relief without the high
Researchers at Leiden University led by Mario van der Stelt (Leiden Institute for Chemistry) have set ‘gold standards’ for developing new painkillers based on the medicinal effects of cannabis. Publication in Nature Communications.
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New potential drug suppresses chemotherapy induced neuropathic pain
Oncode Investigator Mario van der Stelt and his colleagues have discovered a new potential drug that suppresses chemotherapy induced neuropathic pain.
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Open label placebo for itch
Positive expectations can influence sensations of itch and evoke placebo effects, whereas negative expectations can trigger nocebo effects in itch. There is evidence that placebo effects can occur even when people know that they are taking a placebo. Little is known about how these so-called open-label…
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Construction of vast plastics plant by Shell: 'very painful'
Shell, our country's largest company, is constructing a vast plastics plant in the United States. And it is doing so at a time when the European Union, led by the Netherlands, is launching a major pact to combat use of plastic.
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Resetting the immune system to cure diabetes and rheumatism
In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.
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Placebo research: Pharmacological conditioning
The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…
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Sensory Processing Sensitivity, concept and measurement
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Topic: E-health
The research connected to this topic is related to E-health.
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Tiny, pain-free vaccinations: microneedles and nanoparticles
If it’s up to PhD student Guangsheng Du, patients don’t need to worry about big needles anymore. At the Leiden Academic Center for Drug Research (LACDR), he studied the use of microneedles and nanoparticles as a new vaccination system. ‘I want to create a more patient-friendly delivery method.’ He defends…
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Programme structure
The master's specialisation Health and Medical Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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Sofie Rasmussen
Science
a.s.b.rasmussen@cml.leidenuniv.nl | +31 71 527 2727
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Innovative diagnostics and treatments
The more we learn about a (neuro-)psychological or physical disorder and the related behavioral factors, the better we can not only identify them, but also treat them. It is therefore important that recent insights about (neuro-)psychological problems and related behavioral factors are incorporated…
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Topic: Work and health
The research connected to this topic is related to Work and health.
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Two Veni grants awarded to Leiden Psychology researchers
Two Leiden researchers of the Institute of Psychology have been given the opportunity to realise their research plans for the coming three years thanks to a Veni grant from the Netherlands organisation for scientific research. Hanneke Hendriks is researcher in the field of Social and organisational…
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Topic: Psychopharmacology in Health and Medical Psychology
In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.
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Fundamental research: Underlying mechanisms of disease and health
To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.
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One step closer to pain-free vaccinations
Microneedles are a promising tool for the painless administration of vaccines through the skin. But, are these minuscule needles really effective? PhD student Pim Schipper of the Leiden Academic Centre for Drug Research investigated various factors of vaccination via the skin and discovered, among other…
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Research
The research carried out within the unit Health, Medical and Neuropsychology investigates the psychological factors of health and disease, and the development of innovative treatment.
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Topic: Placebo effects
The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…
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Programme structure
The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.
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What happens on the schoolyard? Sensors on clothing reveal painful patterns
Wat gebeurt er op het schoolplein? Sensoren op kleding openbaren pijnlijke patronen