PhD candidate Vincent Walstra reflects on alternative social interactions and mutual aid in the city of Rotterdam during the first wave of the Covid-19 pandemic.

Epithelial cells play a crucial role in the lungs. PhD student Ying Wang researched the effects of cigarette smoke and viruses such as COVID-19 on these epithelial cells. ‘We hope to reduce the risk of pandemics in the future.’

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

The leading medical journal The Lancet has withdrawn a controversial publication on the antimalarial drug hydroxychloroquine. The reason for this is the open letter to The Lancet that over a hundred scientists signed, including Richard Gill, Leiden Professor emeritus of Mathematical statistics.

Together with physiotherapist and lifestyle therapist Jaap Wonders of SMC Rijnland, Helen Pluut conducted research during the first COVID-19 wave on the experiences of working people. The reason for the research was the compulsory situation of working from home many people found themselves in. One of…

Even though the COVID-crisis continuously evolves and is marked by new realities and uncertainties, we can carefully begin to take stock looking back on the first phases of Dutch crisis management. What can we learn reflecting on the crisis strategies of this extraordinary and transboundary crisis that…

Yuven Muniandy (36) from Malaysia recently obtained a PhD from Leiden University. His ‘orientation year’ visa gives him a year to find work in the Netherlands. But with Covid-19, companies have frozen recruitment. Yuven and seven other graduates are asking for a visa extension. He explains why.

The Covid-19 pandemic has challenged political leaders worldwide, bringing discussion about leadership in times of crisis. In various media outlets, a recurring topic has been the relationship between the gender of a country’s leader and the success of his or her Covid-19 approach. Especially female…

The CARICOM-MERCOSUR Chamber has confirmed its participation at the ‘Trade Beyond COVID-19: Building Resilience’, a public seminar organized by the World Trade Organization.

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In accordance with the present travel advice issued by Leiden University and KU Leuven concerning student mobility abroad, it is highly unlikely that the ‘Egyptology in the Field’ programme will be able to take place as normal in Egypt during the 2020-2021 academic year

The Minister has requested urgent advice from Sombroek-van Doorm in relation to the vaccination of children aged between 5 and 12 years against COVID-19.

Ijeoma Uchegbu is Professor of Pharmacy at University College London (UCL). As a female scientist of colour, she was initially reluctant to play an active role in the university’s diversity policy. Until, that is, she had a radical change of heart: ‘I knew it; I had to become an evangelist.'

Evaluations of a most challenging year to both staff and students in terms of teaching and education support have turned out remarkably well. Although we had to switch to online education almost overnight, we pulled it off!

Research into depression in children, Leiden alumni in the Dutch House of Representatives and an exceptional achievement by one of our students: what do this topics have in common? They are among our most read stories of 2021.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

Can the KLM reject an applicant for a job as a pilot or stewardess if they refuse to get vaccinated against Covid-19? Or put more broadly: can the employer of a new employee demand that they are vaccinated? Those questions were at the centre of court proceedings brought on Thursday by the Dutch Airline…

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

The previous blog post in this series discussed the role of international diplomacy during the coronavirus crisis. This post focuses on diplomacy and its challenges in post-corona times. Specifically, the blog post argues that diplomats will face a range of challenges following the Covid-19 pandemic…

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

Key publications of the Skin Barrier and Vaccination group.

Chiodo

From a new generation of antibiotics and more-effective vaccines to a map of dark matter and new light on Hindu traditions. Four researchers from Leiden University have received a prestigious €2.5m ERC Advanced Grant to develop their research.

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Political Scientist Gisela Hirschmann (Leiden University) asks how international organisations can be compelled to comply with respect human rights. She finds that this is done through ‘pluralist accountability’: external third parties such as courts, NGOs, or regional organisations holding international…

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The Leiden Bio Science Park (LBSP) is very important not only for the city of Leiden but also for the Leiden region and the Netherlands as a whole. This is the finding of an investigation conducted by the Leiden-Leiderdorp Audit Committee. The large-scale development of the LBSP in recent years has…

PhD defence

The COVID-19 pandemic forced many staff of Leiden institutes abroad to leave their posts in a hurry. How is the KITLV Jakarta team doing now? Director Marrik Bellen talks about the turbulent times for this Leiden institute and its staff. And can we learn anything from the Indonesian approach?

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

LACDR, the Leiden Institute for Drug Research, developed better tolerated excipients to prevent adverse effects related to the surface of nanosized drugs such as vaccines. LADCR professor of Biopharmacy Matthias Barz and Polypeptide Therapeutic Solutions (PTS) are collaborating to develop processes…

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

From studying molecules in the blood of corona patients to developing a new concept for vaccines. The Leiden Academic Centre for Drug Research (LACDR) has transformed many ongoing projects into Covid research projects. Hubertus Irth, scientific director of LACDR, talks about the role of his institute…

The Covid-19 'infodemic' and conflict resolution by internet platforms.

The Netherlands in September 2021 could be characterised as a low-trust society. Trust in the government has declined significantly in the past one-and-a-half years: from almost 70 percent in April 2020 to less than 30 percent in September 2021. There has also been a slight decrease in trust between…

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

COVID-19 poses a significant barrier to intra-regional trade within the EAC, causing interminable hold-ups at the internal borders.