2,788 search results for “development 26 disease” in the Public website
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PhD candidates in their own words
The Data Science Research Programme at Leiden University combines data science with PhD projects in a wide range of disciplines. The programme has been running for over two years, and is producing the first astonishing results. A number of PhD candidates talk about their experiences and research bel…
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Why Leiden University?
The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…
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Research
The Faculties of Leiden University have developed several themes for research cooperation between Leiden University and its Indonesian partners.
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Increased striatal activity in adolescence benefits learning
Heightened activation of the striatum that adolescents show in response to reward is often associated with risk-taking and negative health consequences. This article in Nature Communications investigates a potential positive side of this heightened activation. It shows that the activity peak in late…
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Tailored medicines
Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.
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Hypoxic Signalling and Tuberculosis
IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.
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Drugging the undruggable: NWO Open Competition grant for Alireza Mashaghi
Finding structure in disordered proteins and developing drugs for undruggable diseases: it might sound like mission impossible, but pharmacologist Alireza Mashaghi and his team are right on top of it. Their project was awarded by NWO through the Open Competition Domain Science -XS, a competition that…
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Ten million euros for unlocking novel technologies in structural biology
The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…
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Vision and Imaging
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Topic: Novelty and enrichment
One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…
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Research ecosystem
The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…
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Blood vessels on a chip make the cause of dementia visible
New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Worm and stomach bacteria: our allies in the battle against allergic asthma
Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.
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Topic: Aging and neuropsychological rehabilitation
Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…
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The researchers
Professor of Ecotoxicology Martina Vijver and lecturer Maarten Schrama are the founders and managers of the Living Lab. As well as these two researchers, a number of other ecologists and biologists are involved in the research at the Lab.
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16th International Metabolomics Workshop
The Basics and Applications to Plant Sciences will be held physical. See below for more information.
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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Archaeological Sciences
With the emergence of new methods and technologies such as improved DNA analysis and big data, archaeological research has changed radically in recent decades. The researchers from the Department of Archaeological Sciences at the Faculty of Archaeology use new scientific knowledge to answer fundamental…
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Programme structure
Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.
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Career prospects
A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.
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King of Sweden visits Leiden University
Collaborating in drug discovery and health research was the goal of a visit to the Leiden Bio Science Park on 14 May by a Swedish delegation including His Majesty King Carl XVI Gustav of Sweden. The delegation visited Leiden University’s Faculty of Science.
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enter into a Framework Agreement on Development Cooperation with the aim of fostering economic development
The Southern African Development Community (SADC) and the Federal Republic of Germany solidified their commitment to collaborative development with the signing of the SADC-German Framework Agreement on Development Cooperation.
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Homicide and Immigration: Trends and Developments
In their recent blog, Marieke Liem and Jolien van Breen reflect on the representation of immigrants amongst homicide victims - is there evidence that people from immigrant groups are over-represented amongst homicide victims? And if so, can we discover the reasons why? Find out more through the link…
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Cleveringa chair
The Cleveringa chair was installed by Leiden University in memory of Professor Rudolph Pabus Cleveringa and the courage he demonstrated in November 1940 during the German occupation (1940-1945). It also commemorates the liberation of the Netherlands in 1945.
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Casting Call: How does a European politician save a refugee from drowning? - installation by Eleni Kamma
Would it be possible for local and traditional European forms of parrhesiastic theater—by which Eleni Kamma means events, actions, and performances staged by characters who courageously speak their minds through scenes of excess and laughter, that take place in public view and incite the spectator’s…
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Social Assistance and Minimum Income Levels and Replacement Rates Dataset
The Social Assistance and Minimum Income Levels and Replacement Rates Dataset, assembled by Jinxian Wang and Olaf van Vliet (version December 2016), provides data on minimum income benefit schemes in 33 countries from 1990 until 2009.
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Governance and Global Affairs
Knowledge that benefits society is the domain of the Faculty of Governance and Global Affairs (FGGA). FGGA provides high-quality interdisciplinary education on and research into social and governance issues such as terrorism, organisation of public administration, climate change and economic crises.
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Awards and Grants 2019
An overview of awards and prizes granted to our staff and students in 2019, as well as special appointments and royal distinctions.
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Looking for happiness and personal development
There are not many classes in which students can talk about their fears, self-critique, or their own happiness. In the Bachelor Honours Class ‘Personal Flourishing and Happiness’, this is exactly the plan.
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Chemical tools to monitor and control human proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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D-lightful Sunshine Disrupted
This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.
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Medical Systems Biophysics and Bioengineering
The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
- Prof Dr Consuelo De Moraes
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Harnessing the soil microbiome for improved stress tolerance in crop plants
Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?
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Indanes-Properties, Preparation, and Presence in Ligands for G Protein Coupled Receptors
The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.
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Bio-informatics lab
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Support Departments
List of Support Departments at LION and the Faculty of Science
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Clock disruption in diurnal versus nocturnal migrating fish
Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?
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Illness and Literature in the Low Countries. From the Middle Ages until the 21th Century
From as early as classical antiquity there has been an interplay between literature and medicine.
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Human Osteology and Funeral Archaeology
The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…
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Neurofibromatosis Type I
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Chemical biology of antigen presentation by MHC molecules
MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez