2,320 search results for “development disease” in the Public website
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16th International Metabolomics Workshop
The Basics and Applications to Plant Sciences will be held physical. See below for more information.
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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induction programs on beginning teachers'well-being and professional development
This thesis reports on the influence of induction programs on beginning teachers’ well-being and professional development, and the essential characteristics of an induction program. These topics were explored by means of an interview study and large scale survey study.
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Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice
Miriam Cohen defended her PhD dissertation entitled “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” on 28 June 2017. She wrote her thesis under the supervision of Professor L.J. van den Herik and Professor C. Stahn.
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Research
Developing computational algorithms for structural biology -A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve…
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Research
The research carried out within the unit Health, Medical and Neuropsychology investigates the psychological factors of health and disease, and the development of innovative treatment.
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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We all BENEFIT: The Ecosystem for Healthy Living
The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…
- Practical Information
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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Magnetic Resonance Imaging of the Adult Zebrafish
Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…
- About this minor
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: J.N. Kok, Co-promotor: F.J. Verbeek
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Developing drawing skill: Exploring the role of parental support and cultural learning
Drawing is one of the most unique human behaviours. Like language, drawing is a mode of communication and a cognitive tool that from an early age allows us to interact with others. Is the early development of drawing skill influenced by the social environment? If so, how?
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CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mi
Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.
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Opening Minor Sustainable Development
The new CML minor Sustainable Development started on Monday 7 September 2009 with an official opening by the Vice-Rector Prof. Rietje van Dam.
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Parallel developments in floral adaptations to obligate moth pollination mutualism in tribe Phyllantheae (Phyllanthaceae)
This article discusses the coevolution of several species of the tribe Phyllantheae and moths of the genus Epicephala.
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Digitizing security: How digital risk-profiling is developed in practice
How are digital risk-profiles developed and used in practice?
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Bòsò Walikan Malangan: Structure and development of a Javanese reversed language
On the 24th of October, Nurenzia Yannuar successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Nurenzia on this achievement.
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Finding the cause of memory loss
Memory loss and confusion are signs of Alzheimer’s disease. Physicists Serge Rombouts and Martina Huber have developed new methods to help medical science get to the bottom of this insidious disease.
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Information activities
Do you want to know more about Cultural Anthropology and Development Sociology and what it is like to study in Leiden? Come to our online or on campus information events.
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'Migraine requires a gender-specific approach'
Migraine is a brain disease. If it were simple, we would have solved it already'. That is the title of the inaugural lecture delivered by Professor of Neurology Gisela Terwindt on Friday 3 June. In her speech she emphasises the importance of research into the differences between women and men with m…
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Development of cross-protective influenza A vaccines based on cellular responses
Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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ImBod | Embodied Imamate: Mapping the Development of the Early Shiʿi Community 700-900 CE
Imami Shiʿism was a key part of the turbulent thesis and antithesis which formed Islam, and it remains greatly influential today. The aim of the ImBod project is to write the first comprehensive social history of the Imamate.
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of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Personalised sarcoma care: Leiden mathematicians develop a prediction app
The DASPO-group for data analysis and survival in personalized sarcoma at the Mathematical Institute has developed an app that provides personalised predictions for patients suffering from soft tissue sarcomas. Due to the aggressive nature of such tumors, the prognosis for such patients is poor, even…
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Ageing
As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.
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Lessons from Rare Diseases
PhD defence
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Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Miranda van Eck inaugural lecture: detergent tablets for clean, fat-free blood vessels
In her inaugural lecture on 11 September, Miranda van Eck, Professor of Cardiovascular and Metabolic Therapeutics, addressed her research related to developing medications to keep our blood vessels clean.
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Osteoarchaeologist Maia Casna interviewed on a podcast
PhD candidate Maia Casna was a guest on the new episode of the Wetenschappelijke Wezens podcast. In it, Maia discusses her research on urbanisation and respiratory diseases while uncovering the intricacies of studying the human past and bones.
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NACTAR: The lugdunomycins: a new class of polyketide antibiotics with unique chemical scaffold
Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.
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Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…
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The right diagnosis and faster for women with heart problems
It often takes longer for women with heart problems to get the right diagnosis. In her Annie Romein-Verschoor Lecture, Professor Hester den Ruijter will talk about how hormones influence the heart and the importance of medical research that focuses specifically on women.
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Religion, Class, and the Postwar Development of the Dutch Welfare State
Religion, Class, and the Postwar Development of the Dutch Welfare State. Dennie Oude Nijhuis.
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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European foreign policy in times of crisis: a political development lens
EU foreign policy has become increasingly politicised over the past years, amongst others as a consequence of the succession of crises. Crises may engender processes of crisis framing and contestation. This article focuses on how the policy demands being voiced in these processes of contestation are…