2,075 search results for “disease prevention” in the Public website
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Course content
The Master’s programme Health, Ageing and Society trains its students to become academic Health, Ageing and Society professionals and engaged citizens who are competent and trained internationally and interdisciplinary. They are able to contribute to solutions for the challenges facing our ageing so…
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Inhibiting protein production potentially a weapon against Alzheimer’s
Inhibiting specific protein production in the human body can serve as a crucial weapon in the fight against Alzheimer's, Eline van Maanen believes. PhD defence 23 November.
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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Africa reconsidered
If you follow the western media, you are likely to think of ‘Africa’ as the continent of origin of desperate migrants, a continent of hunger and disease and a breeding ground for international terrorism. But if you want to see the bigger picture, you should look no further than the African Studies scholars…
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New Methods for (f)MRI Analysis
Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.
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Cool little kids
Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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Archaeology of the Lower Maroni River
The application of compliance archaeology techniques such as mechanical large scale excavations where large quantities of data are gathered in relatively little time (and relatively inexpensively) and a firm post-excavation research phase yielded a whole new body of archaeological evidence.
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Knowledge of DNA repair in the fight against tumour cells
What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.
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The Dutch Network Science Society Symposium 2022 was a success
Back after pandemic interruptions, the Dutch Network Science Society Symposium took place on May 19th, 2022. The event brought together researchers from around The Netherlands studying complex networks and representing various disciplines, including mathematics, physics, neuroscience, computer science,…
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R-ELEVATION
How do plant defense genes get activated?
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Herman Spaink
Science
h.p.spaink@biology.leidenuniv.nl | +31 71 527 5055
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Paul Hooykaas
Science
p.j.j.hooykaas@biology.leidenuniv.nl | +31 71 527 4933
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Veronique de Gucht
Faculteit der Sociale Wetenschappen
degucht@fsw.leidenuniv.nl | +31 71 527 3863
- Event: Preventing Future Ukraines
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Ageing
As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.
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PhD candidates in their own words
The Data Science Research Programme at Leiden University combines data science with PhD projects in a wide range of disciplines. The programme has been running for over two years, and is producing the first astonishing results. A number of PhD candidates talk about their experiences and research bel…
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Lessons from Rare Diseases
PhD defence
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Dr. Kiefte-de Jong and Dr. Bosker, Assistant Professors at LUC, both awarded LUF Awards
Dr. Jessica Kiefte-de Jong and Dr. Thijs Bosker, both Assistant Professors at LUC, have been awarded by The Leiden University Fund (LUF).
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Cell architecture and pathways for parallel secretion in the filamentous fungus Aspergillus niger
Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Plant ageing, rejuvenation and life history strategy
What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?
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Nose of E. coli zips open and shut
PhD student Wen Yang discovered how certain cell receptors in E. coli bacteria signal 'smells'. With the use of ice-cold electron microscopy microbiologists from Leiden gain more insight into how bacteria respond to their environment. Publication in mBio.
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Why don't drugs make it to the market?
How can we extend the drug residence time to combat diseases more effectively?
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Vertebrate automated screening technology (VAST)
How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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CoSTREAM: Understanding Stroke and Alzheimer
The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Rational Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
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Research
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Violent extremism
This online advanced summer programme, organised together with the International Centre for Counter-Terrorism – The Hague (ICCT), provides insight into the opportunities and challenges of various approaches to prevent, detect and respond to violent extremism.
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Governance of Violence (MSc)
What is the nature and scope of violence? Who offends, and in what context? Who are the victims? And how can we design suitable intervention and prevention strategies? In this track, you will be familiarised with the many faces of violent offending, to provide the knowledge and tools to understand,…
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Assistant professor "Inflammation pathways in atherosclerosis"
Science, Leiden Academic Centre for Drug Research (LACDR)
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Data Analytics and Management
Our group is part of the Metabolomics and Analytics Centre where we accompany the data from its acquisition all the way to the publication of identified associations and biomarkers for a range of human diseases. The generated data of the metabolic measurements are assessed using an in-house quality…
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Fundamental and translational medical biochemistry
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Reducing the chronic disease burden in China
PhD defence
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Research with animals
At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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ADAPTED
The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).