2,514 search results for “drug research” in the Public website
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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The Netherlands-Flemish Institute in Cairo provides myriad forms of assistance to researchers from our affiliated institutions. For more information on the current research NVIC is involved in, please select your field of academic interest on the left.
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The philosophers at the Institute of Philosophy develop new perspectives and insights not only on fundamental philosophical questions, but also on topical and interdisciplinary themes such as secrecy, migration, climate change, the politics of truth and intercultural relations.
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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Find out more about the impact of Brexit on research projects.
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The faculty’s scientific research is organised around a number of centres and institutes in The Hague, city of peace, security and justice.
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LUCAS’ Medieval and Early Modern (MEM) cluster brings together expertise in the fields of art, literature and media. It focuses on the arts in society in Europe and beyond during a vast period of time, from the 7th through to the 18th centuries CE.
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Research within the department of Philosophy of Law is mainly focused on the history of the philosophy of law.
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Leiden Law School has a long tradition of research in Air Law and, of more recent vintage, in Space Law.
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LIAS has a School of Asian Studies (SAS), a School of Middle-Eastern Studies (SMES) and a School of Religious Studies (LUCSoR). These designations, and the fields within them, remain foundational to our work. At the same time, the academic community benefits from the presence of cross-regional networks…
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Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:
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The Leiden Leadership Centre conducts research into the development of effective public leadership within and between organisations. On the basis of our research and development agenda ‘Furthering Public Leadership’, we focus on public leadership in a public context, on its societal impact, and on leadership…
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Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…
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Research highlights
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Reliable research with virtual patients
The right medicine in the right dosage for every patient, that is something medical science aspires. 'Personalised medicine' is the term for that. But it does require a lot of research with patient data and that can be hard to get due to privacy legislation. Researchers Laura Zwep and Coen van Hasselt…
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Enduring influence of Roman law
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The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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The main goal of the research that is conducted in the Brain and Education Lab is to create a better understanding of the cognitive and neural systems that support learning and academic performance across development. To pursue this goal, lab members draw on theories and methods from developmental and…
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The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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The conquest by Rome brought profound changes to large parts of Europe. Unprecedented infrastructural works such as roads and harbours were created, towns sprang up, a ribbon of fortresses was laid out along the frontiers and there is a vast increase in material culture to inform us about the lives…
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At the Sport Data Center, five research themes are explored.
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Chemistry research for better chemotherapy Finalist PNAS paper award
Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.
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The research within the Liveable Planet programme is clustered around four themes. Find out why these topics deserve our attention.
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The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.
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At Leiden University, researchers from all disciplines work together to find answers and design innovations in the field of artificial intelligence.
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Bio-organic Synthesis
The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…
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Overview of the main research projects at the Leiden Papyrological Institute.
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Janssen COVID-19 vaccine approved for use in EU
The Janssen-Cilag International N.V COVID-19 vaccine has received authorization for emergency use by the European Medicines Agency (EMA) on March 11. The vaccine was developed with fundamental support from the Molecular Virology group of the Leiden University Medical Centre (LUMC).
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Academic Pharma submits application to National Growth Fund
Knowledge institutions in the Netherlands are to work together with the pharma and biotech industries to accelerate drug discovery and development. To bridge the ‘lab-to-life’ gap, Leiden University and the LUMC have, as coordinators of Academic Pharma, submitted an application to the National Growth…
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The GTGC network currently spans over 200 researchers across 6 faculties at Leiden University. We especially foster thematic interfaculty collaborations on a wide variety of global transformations and governance challenges.
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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How do people acquire language? How can you train your brain? What is the effect of stress on an unborn child? LIBC research topics range from language processing to cognitive robotics, and from psychiatric disorders to the impact of social factors on human behaviour. Meet several main research topics…
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CompaRe aims to conduct and stimulate research on comparative regional integration in Europa, Asia, Africa and Latin-America. To this end, CompaRe organizes conferences and workshops, and CompaRe members contribute to conferences, research papers, publications and reports on comparative regional…
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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These eleven Leiden Science researchers are among the most highly cited
Eleven researchers of the Faculty of Science are on the 2021 Highly Cited Researchers list of Clarivate Analytics. Only 0.1 per cent of researchers are included in this list, literally making them one in a thousand.
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Flagships
In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.
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The LLRC has collaborated on developing the communicative tasks for the Leiden Learner Corpus (LLC).
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Our research examines mental health risk and resilience in young people. We do so by integrating cultural, social, cognitive and neurobiological factors and their interactions.
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The CSPRR hosts several research projects.
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Research at the THEOR group is comprised of the following research themes:
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Labour law is constantly changing. Concurrently, the laws dealing with workers address fundamental issues which are invariably of major significance and value. The research carried out at the Department of Labour Law and Social Security focusses on both the (constant) changes in labour law and social…
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Regulation of nanoparticle biodistribution by scavenger endothelial cells (SECs)
A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…
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Research at the BIOSYN group is comprised of the following research themes: