Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

In what way can the qualities of an existing context be used as guiding and enriching principles rather than limiting factors in the process of spatial transformation?

Towards Health and Resilience in Volatile Environments - People differ in how they are impacted by and respond to stressful experiences. Why is that?

Some conflicts involve many Muslims as foreign fighters; other conflicts attract only relatively few combatants from abroad. Isabele Duvesteyn and Bram Peeters

The main interest of this project concerns learners’ perceived learning outcomes in massive open online courses and the factors related to their perceived learning outcomes.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

What are relationships between student teachers’ personal characteristics, learning experiences and perception of external environmental aspects impacting teacher career and their commitment to teaching?

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

This project will construct an inventory of possible conceptions of the resistance of the world to scientists’ claims and theories.

In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…

Each year, the Leids Universitair Fonds (LUF) awards grants to research and educational project in various academic fields. In 2019, dr. Tanachia Ashikali received a grant to conduct an in-depth study into the determinants of inclusive leadership in public organisations: What does it take to be an inclusive…

What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

Professor of Ecotoxicology Martina Vijver and lecturer Maarten Schrama are the founders and managers of the Living Lab. As well as these two researchers, a number of other ecologists and biologists are involved in the research at the Lab.

The NestWacht project is a Citizen Science collaboration between Science Centre Delft, Naturalis, and the Citizen Science Lab of Leiden University to engage individuals, families and primary schools in Leiden and Delft in scientific research on the impact of climate change on nature in their city, and…

Some children and adolescents find it hard to attend school because of anxiety and/or depression, a problem which is often referred to as school refusal. The main research question is how we can best help these young people reduce their emotional distress and increase their school attendance in order…

Making the Virtuagym e-platform suitable for wheelchair users with a spinal cord injury or lower limb amputation.

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

Cognitive enhancement reflects the use of any (legitimate) means such as for example food supplements to reach one’s personal best.

Investigating neurobiological endophenotypes of Social Anxiety Disorder

Language learners in higher education increasingly conduct out-of-class self-directed learning facilitated by mobile technology. This project aims to explore how university students use mobile technology for their self-directed language learning and investigate factors that influence their self-directed…

The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.

Five talks will be given during the Leiden Science Family Day: two children's lectures and three lectures for adults. Will you be there ?

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

Which metabolites of sponge are influenced by individual environmental or biological factors?

-

On 4 March 2021, Michiel Spanjers defended his thesis 'Belastingbudget'. The doctoral research was supervised by Prof. J.P. Boer and Prof. H. Vording.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

Trust in public institutions in the Tata Steel case and beyond

Nadine Raaphorst wrote an chapter for The Oxford Handbook of Administrative Justice about how two notions of fairness are studied in street-level bureaucracy literature and about the factors that influence how bureaucrats behave in this regard.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

The program group Learning and Behavior Problems in Education: Challenges and Solutions strive to find solutions to the learning and behavior challenges faced by preschool and elementary-school children, youth, and young adults in education. In doing so, the group focuses on cognition and behavior and…

Wijayanto defended his thesis on 17 January 2019

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Abdolreza Alamdar Baghini defended his thesis on 5 December 2019.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

On 17 November 2021, Cyril-Igor Grigorieff defended the thesis 'The Regime for International Air Carrier Liability'. The doctoral research was supervised by Prof. P. Mendes de Leon and Prof. V. Correia (University Paris Saclay).

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

Understanding the water use of power production is an important step to both a sustainable energy transition and an improved understanding of water conservation measures. However, there are large differences across the literature that currently present barriers to decision making.

The motivation of student teachers for the teacher's profession depends on various factors. Teacher training can influence the commitment of students.