2,627 search results for “heart and vascular disease” in the Public website
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Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
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Reconstruction and Computational Modelling for Inherited Metabolic Diseases
Accelerating the diagnosis and personalising the management of inherited metabolic diseases.
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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The right diagnosis and faster for women with heart problems
It often takes longer for women with heart problems to get the right diagnosis. In her Annie Romein-Verschoor Lecture, Professor Hester den Ruijter will talk about how hormones influence the heart and the importance of medical research that focuses specifically on women.
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Cardiovascular and Metabolic Therapeutics
This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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smartphone behaviour to understand healthy ageing and neurological disease
Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Fundamental research: Underlying mechanisms of disease and health
To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.
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Lifestyle and nutrition to combat diseases (of affluence)
We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…
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Postdoc fellowship from the Dr. E. Dekker stipendium awarded by the Dutch Heart Foundation.
Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.
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Pharmacotherapy and Ventilatory Control in Health and Disease
PhD defence
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Key publications
Key publications of the Aging and Immunity group
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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The Layered Heart: Essays on Persian Poetry, A Celebration in Honor of Dick Davis
The Layered Heart : Essays on Persian Poetry is published in celebration of the poet and scholar Dick Davis, dubbed “our pre-eminent translator from Persian” by The Washington Post.
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Miranda van Eck hoogleraar Cardio Vascular & Metabolomic Therapeutics
Miranda van Eck is benoemd tot hoogleraar Cardio Vascular & Metabolomic Therapeutics bij het Leiden Academic Center for Drug Research (LACDR) van de faculteit der Wiskunde en Natuurwetenschappen. De benoeming ging per per 1 februari 2014 in.
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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Research in Africa reduces health spending and prevents diseases of affluence
Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Curing diseases with lab-grown organs
Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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Bram Slütter
Science
b.a.slutter@lacdr.leidenuniv.nl | +31 71 527 6208
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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Stressed brain, stressed heart?
Ilze Bot and Johan Kuiper have published in The Lancet: Study unveils how stress may increase risk of heart disease and stroke. Aso: The National Dutch newspaper 'NRC' has mentioned them in a column
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stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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miniaturised assays for structure-resolved lipidomics in metabolic disease
PhD defence
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A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
PhD defence
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Frits Rosendaal
Faculteit Geneeskunde
f.r.rosendaal@lumc.nl | +31 71 526 4037
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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Macrophage activation and cholesterol accumulation in atherosclerosis development
Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck
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Almost 19 million euros for development and study of organs-on-chips
It sounds futuristic, but it is possible: the creation of miniature organs of patients in order to study them and see how diseases develop and can be treated. This is what researchers from the LUMC, Twente University (UT), UMCG, TU Delft and the Hubrecht Institute hope to achieve in the next ten years…
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Antonius Johannes Rabelink
Faculteit Geneeskunde
a.j.rabelink@lumc.nl | +31 71 526 2148
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Maximal Systolic Acceleration in atherosclerotic vascular disease
PhD defence
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'Leiden has stolen my heart'
Xueyan Xing (right on the photo) comes from Anhui Province, China. Having studied at Leiden University College The Hague, she is now taking a master’s degree in Political Science. 'The libraries are my second home.'
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Dorien Peters
Faculteit Geneeskunde
d.j.m.peters@lumc.nl | +31 71 526 9490
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Paulus Quax
Faculteit Geneeskunde
p.h.a.quax@lumc.nl | +31 71 526 1584
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Bart Verkuil
Faculteit der Sociale Wetenschappen
bverkuil@fsw.leidenuniv.nl | +31 71 527 3460
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Atherosclerosis resembles an autoimmune disease. Marie Depuydt graduated on this topic, with honours
In addition to cholesterol and high blood pressure as risk factors for atherosclerosis, we may need to address our own immune system to prevent a heart attack or stroke. Marie Depuydt revealed which cells exactly reside in the atherosclerotic plaque that narrows an artery. The presence of a diverse…
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Preventing or curing diseases with X-omics
In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.