This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Does foreign aid promote human rights?

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…

This summer school focuses on the emergence of sexual orientation, gender identity (SOGI) and intersex issues in different areas of international law, such as human rights law, refugee law, international economic law, and international criminal law. Further information for this summer course will be…

Eduard Fosch-Villaronga, Associate Professor at eLaw, contributed to 'Cyber–Physical–Human Systems', a book exploring the latest developments in interactions between cyber–physical systems and humans.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Lecture

On Thursday 20 May 2021, Tania Li delivered the annual Van Vollenhoven Lecture.

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

Collecting as much information as possible about administering a new medicine to people can save a lot of money.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

You can ask virtual assistant Siri about the weather, but you can’t have a real conversation with it yet. You can’t refer to anything that’s been said before, or ask the system why it says what it says. Stephan Raaijmakers, Professor by Special Appointment from TNO, hopes to change this.

If an algorithm has to learn to understand language, simply having a lot of data doesn’t help much. Like us, a computer has to learn the language in interaction with others. Tessa Verhoef is fascinated by how this interaction works.

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…

Tens of thousands of soldiers and civilians have died as a result of Russia’s invasion of Ukraine in February 2022 and the continuing armed conflict. Many forms of critical infrastructure have been destroyed. Much of this devastation has been caused by weapons that utilise forms of artificial intelligence…

Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…

Two Vidi subsidies for Faculty of Archaeology.

Friday October 24th Honours students had to present their case studies on a topical issue related to Humanities. All Honours students made posters in pairs of two and had to defend their case in front of an audience at the Old Observatory. It was a tense experience, since they were being graded by…

Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…

In the last weeks, ASEAN published different Statements about the human rights situation in Myanmar and the Democratic People´s Republic of Korea (DPRK).

The routine assumption that Upper Palaeolithic early modern humans in Europe were regular fire users who produced fire at will has never been tested against the archaeological record. Utilizing literature, database and microwear analytical approaches, this project seeks to establish the role and forms…

On 7 May 2020, Jolanda van der Vliet defended her thesis 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. J.J.C. Voorhoeve.

When you think of humanities, you may not immediately think of a new super server. Yet one has just been commissioned. University lecturer Jelena Prokic from Leiden University Centre for Digital Humanities explains more about this development.

In addition to his Film and Literature Studies, Bob van Oosterhout is a bassoonist with several orchestras. He is going to Milan with the student choir and orchestra ‘Collegium Musicum’.

Since the emergence of humankind people have maintained social contacts and traveled widely, establishing interaction networks in which goods are traded and ideas are transmitted, increasingly on a global scale.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

The humanities consist of various academic fields. But what is the common ground of all these different academics and students? And why does their work matter so much in today’s world? Watch the trailer of Humans of Humanties, the new documentary film about the Leiden Faculty of Humanities. Will you…

On Wednesday 13 December, Melanie Fink will defend her doctoral thesis ‘Frontex and Human Rights: Responsibility in “Multi-Actor Situations” under the ECHR and EU Public Liability Law’. The defence will take place at 10.00 hrs at the Academy Building of Leiden University, Rapenburg 73. The supervisors…

It's easy to forget in these turbulent times, but on March 9th the film 'Humans of Humanities' premiered in cinema Trianon in Leiden. 160 guests saw Leiden scientists, teachers, students and alumni talk on the big screen about the value of their work as a humanities scholar. The film was followed by…

This special issue of the peer-reviewed journal Amsterdamer Beiträge zur älteren Germanistik (Brill, 2021) brings together articles that explore new digital ways of analyzing and annotating Old English vocabulary.

To celebrate the end of the semester the Science and Humanities Buddy Programme organised a barbecue together, which has become a small tradition. The barbecue marks the third co-organised activity between the two Programmes and helps to bring international and Dutch students together. The Buddy Programme…

The ECtHR needs to provide effective rights protection, but it also needs to set clear standards while showing deference to decisions made at the national level. Especially when socio-economic issues are concerned, meeting these different demands is a challenging task.