967 search results for “immune system” in the Public website
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vaccines: particle uptake by dendritic cells is a key parameter for immune activation
Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…
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Maria Yazdanbakhsh
Faculteit Geneeskunde
m.yazdanbakhsh@lumc.nl | +31 71 526 5067
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Marieke Tollenaar
Faculteit der Sociale Wetenschappen
m.s.tollenaar@fsw.leidenuniv.nl | +31 71 527 3454
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PhD candidate "Immune effector mechanisms in advanced atherosclerosis"
Science, Leiden Academic Centre for Drug Research (LACDR)
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C1q and anti-C1q autoantibodies in (auto)immunity
PhD defence
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Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.
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Herman Spaink
Science
h.p.spaink@biology.leidenuniv.nl | +31 71 527 5055
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Vaccines Are Highly Thermostable and Induce Both Humoral and Cellular Immune Responses
The potential of bioneedles to deliver influenza vaccines was investigated.
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Psychophysiological responses to stress and stress management
The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.
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Joost Beltman
Science
j.b.beltman@lacdr.leidenuniv.nl | +31 71 527 4323
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Peptide Amphiphile Nanoparticles Enhance the Immune Response Against a CpG-Adjuvanted Influenza Antigen
Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf
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Hierarchical Systems
The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.
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Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Why COVID-19 caused a pandemic (whereas other coronaviruses did not)
Epithelial cells play a crucial role in the lungs. PhD student Ying Wang researched the effects of cigarette smoke and viruses such as COVID-19 on these epithelial cells. ‘We hope to reduce the risk of pandemics in the future.’
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…
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Novel regenerative therapies for the adaptive immune system
PhD defence
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Imaging the (un)imaginable of the Barrier Immune System
PhD defence
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Werken aan een effectiever malariavaccin
In het Leids Universitair Medisch Centrum wordt gewerkt aan de ontwikkeling van een nieuw malariavaccin dat effectiever is dan de huidige vaccins.
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Improving response and reducing toxicity to immune checkpoint blockade therapy in melanoma
PhD defence
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against atherosclerosis; induction of protective CD8 T-cells through immunization
Atherosclerosis, in particular rupture of atherosclerotic plaques, is the underlying cause of most heart attacks or strokes and is the leading cause of death worldwide.
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Unraveling cross-presentation pathways using a chemical biology approach
Is it possible for sugar patterns on cells to activate the immune system to combat cancer?
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Engineering innate immunity for therapy
Immune system defends our body against pathogens and cancerous cells, but excessive immunity can in turn lead to tissue damages and diseases. For example, scratching the surface of the eye ignites an immune response that aims at preventing infection but can also lead to edema, angiogenesis and eventually…
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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New light on innate plant immunity
Plants are able to resist a pathogen’s attack by a dual innate immune system. The relationship between the two pathways was not clear, but it turns out that they mutually potentiate each other, as assistant professor Pingtao Ding (Institute of Biology Leiden) and colleagues (The Sainsbury Laboratory,…
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Specialised immune cells have potential for new cancer immunotherapies
Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…
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Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
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Computer Systems, Imagery & media
The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Live or let die: the intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?
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Spiking Neural P Systems
Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom
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On periodically driven quantum systems
Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth
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Vaccine delivery
Vaccination via the skin or the mucosae
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Systems pharmacology of the endocannabinoid system
What are the functions of the endocannabinoid system?
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Buccal and sublingual vaccine delivery
Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.
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Systems Pharmacology
The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…
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Transcutaneous vaccination by means of coated and hollow microneedles
Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Worm and stomach bacteria: our allies in the battle against allergic asthma
Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.
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Concurrent Systems
In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.
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Systems Pharmacology
The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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Systems & infrastructure
Here are some systems and infrastructures that are useful to students.
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Visualization of the maternal immune system at the maternal-fetal interface
PhD defence
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Latency, Energy, and Schedulability of Real-Time Embedded Systems
Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.