885 search results for “immunity infection and tol” in the Public website
-
Leiden students develop highly contagious card game
Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…
-
LIBC Support
The LIBC is a network focusing on science valorisation and outreach, stimulating interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition. Get to know the support team.
-
Psychophysiological responses to stress and stress management
The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.
-
Delivery of Biotherapeutics
The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.
-
Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
-
Regulation of autophagy-related mechanisms during bacterial infection
PhD defence
-
Renewable Energy
The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.
-
The developing brain and behaviour
The more opportunities a child has to learn and develop, the stronger his or her future position in society. Leiden University investigates how the brain picks up information, and how learning processes can be influenced positively.
-
Governance and society
Governance is a complex puzzle of organisations, people and divergent interests. Academic research in this field furthers our knowledge of the role of public administrators, of different organisational structures, of the people who work at such organisations and of how these organisations implement…
-
A fitting punishment
A punishment that fits the crime is the cornerstone of the rechtsstaat or constitutional state. But opinions differ greatly on what constitutes a just and effective punishment. Research by Leiden University provides politicians, legislators, law enforcers and the public with new information and insights…
-
Probing complex problems
Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.
-
Indigenous Peoples preserved
Indigenous Peoples possess rich worldviews and unique knowledge that form part of our global heritage. Oppressing these peoples and violating their natural environment is leading to the destruction of this knowledge. Leiden researchers aim to counter this through collaborating with Indigenous Peoples…
-
The quantum computer
The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…
-
Spreading the Fire: Why is Pyroptotic Cell Death Contagious?
The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…
-
Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
-
Classical conditioning to improve immunotherapy in cancer
Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?
-
Sustainable futures
How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.
-
Marieke Tollenaar
Faculteit der Sociale Wetenschappen
m.s.tollenaar@fsw.leidenuniv.nl | +31 71 527 3454
-
Patrick van Hage
Science
p.van.hage@biology.leidenuniv.nl | +31 71 527 4950
-
Smartmix: A new generation of efficient biomedical research
Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?
-
Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
-
Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
-
Respiratory health and disease in the Netherlands
Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).
-
Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
-
Unraveling cross-presentation pathways using a chemical biology approach
Is it possible for sugar patterns on cells to activate the immune system to combat cancer?
-
Development of an intradermal tuberculosis vaccine by combining dissolvable microneedle arrays and Mycobacterium tuberculosis antigen-containing
Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…
-
Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
-
ERC-subsidie om uit te zoeken hoe kinderen luchtweginfecties te lijf gaan
De crèche en het klaslokaal zijn misschien wel de meest gunstige plekken voor ziekteverwekkers. Toch is er relatief weinig bekend over hoe kinderen reageren op virussen en bacteriën en hoe het komt dat sommige kinderen veel beter beschermd zijn dan anderen. Simon Jochems, onderzoeker aan het Leids Universitair…
-
Immune checkpoint inhibitors in mesothelioma
PhD defence
-
Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
-
Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
-
Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity
The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.
-
Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
-
Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
-
R-ELEVATION
How do plant defense genes get activated?
-
Vaccine delivery
Vaccination via the skin or the mucosae
-
Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
-
B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
-
Rational Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
-
White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
-
Maurijn van der Zee
Science
m.van.der.zee@biology.leidenuniv.nl | +31 71 527 4885
-
Annemarie Meijer
Science
a.h.meijer@biology.leidenuniv.nl | +31 71 527 4927
-
TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge
TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.
-
Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
-
Research
The Faculties of Leiden University have developed several themes for research cooperation between Leiden University and its Indonesian partners.
-
Endoglin and the immune System
PhD defence
-
Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats
PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.
-
Key publications
Key publications of the Aging and Immunity group
-
Leiden Spinoza and Stevin Prize laureates
Of the 105 Spinoza Prizes that have been awarded since 1995, 26 have gone to researchers from Leiden University. The NWO Spinoza Prize is the highest Dutch award in science. The younger NWO Stevin grant goes to researchers who have achieved great success in the field of knowledge utilisation for society.…
-
Why Biomedical Sciences at Leiden University?
The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.