680 search results for “immunity infection and tol” in the Public website
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Immune Thrombocytopenia: Exploring antibodies, scintigraphy and immune modulation. Moving towards a new era for patients with ITP
PhD defence
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Unwiring beneficial functions and regulatory networks in the plant endosphere
How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Do common antibiotic treatments influence emotional processing?
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Student projects
Are you looking for a research project?
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Antiviral Pharmacology
The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.
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Individualized prognosis in childhood immune thrombocytopenia
PhD defence
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Innovation in treatment and care
Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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Exploring the Dutch Empire: Agents, Networks and Institutions, 1600 - 2000
Dr. Cátia Antunes and prof. Jos Gommans both edited and contributed to this interesting book, that consists of articles that offers a new insight into the macro and micro worlds of the global Dutchman in Asia.
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Host-Microbe Interactions in Animal Sciences
Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.
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Key publications
Key publications of the Biologics Formulation group
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Herman Spaink
Science
h.p.spaink@biology.leidenuniv.nl | +31 71 527 5055
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Jip Stam
Faculteit Rechtsgeleerdheid
j.stam@law.leidenuniv.nl | +31 71 527 6360
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Lison Laroche
Science
l.l.s.laroche@cml.leidenuniv.nl | +31 71 527 2727
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Quest for new antibiotics
Gubbens
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Projects
An overview of Quantitative Pharmacology projects
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Prosthetic Joint Infection, new diagnostic and treatment strategies
PhD defence
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Strategies in the Battle Against Neonatal Nosocomial Infections
PhD defence
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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BEAT-COVID team discovers sugar-coated antibodies that predict disease progression
At the start of the COVID-19 pandemic, researchers from 15 departments at Leiden University Medical Center (LUMC) realised they could do more for patients if they joined forces. This is how the BEAT-COVID group has been able to rapidly gain knowledge about COVID-19, the role of the immune system and…
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First clinical trial with genetically modified malaria vaccine completed
In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.
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Annemarie Meijer appointed full Professor of Immunobiology
Annemarie Meijer is appointed full Professor of Immunobiology. Meijer’s research focuses on immunobiology and infectious disease. She uses the zebrafish as a model for understanding mechanisms of host immune defense against intracellular bacterial pathogens.
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International organisations and the rule of law
International organisations that represent collaborations between States are becoming increasingly more powerful, and they have an increasing impact on our daily lives. For example, the European Court of Human Rights in Strasburg established that minors have a right to legal aid immediately following…
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Characterization of innate immune cells in the glioma microenvironment
PhD defence
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Characterization of innate immune cells in the glioma microenvironment
PhD defence
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REACT Study
The aim of the REACT Study is to examine whether baseline inflammation, and/or neuro-immune responses to stress in a sample of adolescents with experiences of childhood adversity predicts: the perception of stress, social behaviour and general mental and physical health during and after the COVID-19…
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In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice
PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Imaging the (un)imaginable of the Barrier Immune System
PhD defence
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Immune modulation and monitoring of cell therapy in inflammatory disorders
PhD defence
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Novel regenerative therapies for the adaptive immune system
PhD defence
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Malaria researchers from all parts of the world in Leiden
Researchers from all parts of the world will be in Leiden from 2 to 4 May for a major malaria conference. The Leiden University Medical Center (LUMC) is organising a two-day workshop on how vaccines can be tested safely in humans.
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A synthetic vaccine against meningococcus
Leiden chemists recreated the bacterial capsule of meningococcus in the lab. With a few modifications, these capsules can serve as an extra safe and effective vaccine against these notorious bacteria, which can cause, for example, meningitis. PhD candidate Jacopo Enotarpi and his team published the…
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Research
An overview of the research at the Biologics Formulation group
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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Ariane Briegel: 'AI literally opens new worlds for the life sciences'
Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’
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Annemarie Meijer new training coordinator in European network
The new project INFLANET will train young scientists in Europe to become experts in inflammation research. Professor Annemarie Meijer from the Institute of Biology Leiden coordinates the training.
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Amanda Foks receives Dekker grant from Dutch Hartstichting
Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.