In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?

In the specialisation Clinical Neuropsychology, part of the Master in Psychology, you will focus on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

In this dissertation, the types of context Dutch speakers need to interpret the poly-interpretable word ergens ‘somewhere/anywhere’ are studied.

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”

Overkleeft

The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…

Knowledge of mental distress and resilience factors over the time span from before to after a stressor is important to be able to leverage the most promising resilience factors and promote mental health at the right time. To shed light on this topic, we designed the RESIST Study, in which we assessed…

We are all aware of the importance of a healthy lifestyle. However, at the same time we also experience many difficulties when we are trying to change our behavior to become more healthy. For example, more often than not our good intentions to exercise more or to eat fewer unhealthy snacks fail miserably…

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

My ERC Starting Grant, funded with €1.5 million for 5 years as part of the Horizon 2020 research and innovation program, is focused on building the early warning system WARN-D to reliably forecast depression in young adults before it occurs. Why depression, and why prediction?

Some children and adolescents find it hard to attend school because of anxiety and/or depression, a problem which is often referred to as school refusal. The main research question is how we can best help these young people reduce their emotional distress and increase their school attendance in order…

In a recent mega-analysis, researchers from Leiden University aimed to clarify the contradictory findings of research into social anxiety disorder. They found that to obtain reliable research results having the largest possible sample size is important. Publication in NeuroImage:Clinical.

Course, Workshop

There’s a lot that goes wrong in the treatment of patients with PTSD caused by childhood trauma. Endowed professor Maartje Schoorl wants to resolve this by bringing scientific research closer to the practice. Inaugural lecture on Friday 29 April.

PhD defence

Empathic or anxious mistakes? A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Social anxiety disorder is one of the most common disorders in children and young people. Social anxiety is characterized by excessive fear and avoidance of social situations. The primary fear in children with social anxiety is that they will be negatively judged by others. To date, the most frequently…

Which adolescents are more at risk of developing social anxiety disorder later in life?

The life of a students is not always easy and many students find it difficult to share their problems with each other. For that reason, the study advisers and coordinators of studies of Campus The Hague organise the symposium OpenUp!. This event was awarded with the Van Bergen Prize.

Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: Prof.dr. J. den Hertog

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

An assessment approach that tailors to children’s instructional needs

Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.

This guide will give you the necessary help and guidance in submitting your application for the master’s specialisation Clinical Psychology at Leiden University.

This guide will give you the necessary help and guidance in submitting your application for the master’s specialisation School Psychology at Leiden University.

The aim of the RAISE study is to investigate how resilient people respond to stress. Specifically, we will study how key biological systems (HPA-axis, immune system) interact with the brain and social environment in order to facilitate resilient functioning after childhood adversities.