527 search results for “metallic nanoparticles” in the Public website
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Leiden Scientists: 'Environmental risks of new pesticides with nanoparticles insufficiently examined'
The environmental risks of new pesticides containing nanoparticles are inadequately researched, according to four Leiden scientists in the scientific journal Environmental Science & Technology. They call for an examination of the long-term and environmental effects of pesticides containing nanoparti…
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Zhenyang Chen
Science
z.chen@cml.leidenuniv.nl | +31 71 527 2727
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Jingjing Cao
Faculteit Archeologie
j.cao@arch.leidenuniv.nl | +31 71 527 1603
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Robert Istrate
Science
i.r.istrate@cml.leidenuniv.nl | +31 71 527 2727
- Institute of Environmental Sciences
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Final presentations Area Study Sustainability: Wheels of Metals
Friday 30 January 2015 were the final presentations of the last course of the Minor Sustainable Development.
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Hunt for cheap metals that help store sustainable energy
Storing energy is one of the biggest challenges in the energy transition. Hydrogen could be a solution. Chemist Daan den Boer is researching how to make the chemical reaction needed to store energy in hydrogen as cheap and efficient as possible.
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Rik Mom
Science
r.v.mom@lic.leidenuniv.nl | +31 71 527 4221
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Faculty of Science opens academic year with responsibility call and nanoparticles
On Tuesday 4 September, in a full lecture hall C1, Dean Geert de Snoo opened the Academic Year for the Faculty of Science. A year in which the ethics and responsibility of scientists will be invoked.
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Nanoparticles: shapeshifters that pass along the food chain and end up in the brain
Nanomaterials can pass much further along the food chain than was previously thought. The particles can change shape and size in each organism, enabling them to pass on to the next one in the chain. Researchers from the Institute of Environmental Sciences discovered this accidentally when using a novel…
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Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros
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How two metal detectorists discovered a complete Roman treasure
In 2017, in an ordinary field, two brothers from Brabant discovered more than 100 ancient coins. The Leiden historian who examined the coins concluded that they constituted a genuine Roman treasure. Here follows a reconstruction in three acts.
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In the media: Daniela Kraft in Academic Stories about nanoparticle robots
Daniela Kraft speaks to Academic Stories about self-assembling soft matter, nanorobots, the importance of female rodels in science, and the unique freedom and support that Leiden University provides.
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Electrical and magnetic properties of ferritin: electron transport phenomena and electron paramagnetic resonance
Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.
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Selective and efficient electrochemical CO2 reduction on nanostructured catalysts
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Poly-(lactic-co-glycolic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation
Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Luminescence and applications of lanthanoid coordination polymers
Promotor: E. Bouwman, Co-Promotor: S. Bonnet
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Speed gun for molecules
Detecting molecules with temperature instead of chemical reactions: that’s what scientists from the Leiden Institute of Physics want to do. They are developing a sensor that utilizes special nanoparticles to keep track of certain molecules. In this way, they can for example see how well new drugs do…
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TV-Interview Rene Kleijn about metals scarcity in relation to the energy transition
CML-researcher Rene Kleijn has spoken about metals scarcity in relation to the energy transition in a new Dutch popular scientific TV show called
- Martina Huber Lab - EPR Group
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Dissertations
Overview of all dissertations published by PhD candidates from CML.
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Aimee Boyle
Science
a.l.boyle@lic.leidenuniv.nl | +31 71 527 2727
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Carina Harpprecht
Science
c.i.harpprecht@cml.leidenuniv.nl | +31 71 527 2727
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The Metallophilic Interaction between Cyclometalated Complexes: Photobiological Applications
In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.
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semi-local DFT is accurate for dissociative chemisorption on a transition metal surface, and when it is not
Density functional theory (DFT) with so-called semi-local exchange has been remarkable accurate for some dissociative chemisorption reactions on metals, but it has notoriously failed for others. A team of researchers from the University of California at Irvine and the Leiden Institute of Chemistry have…
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Michel Orrit Lab - Single Molecule Optics
Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.
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predictor for variation with geometry of barriers for reactions on metals
A semi-empirical version of the specific reaction parameter approach to density functional theory (SRP-DFT) has been remarkably successful at predicting dissociative chemisorption probability vs. incidence energy curves for reactions on metal surfaces. New quantum Monte Carlo (QMC) calculations on the…
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New method of detecting rapid virus development
Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Rationally designed peptide based functional biomaterials
Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Programme
The symposium is open to all registered participants and consists of two sessions and a Poster Session.
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Development of nanoparticulate adjuvants based on aluminium salts
The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.
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Irene Groot
Science
i.m.n.groot@lic.leidenuniv.nl | +31 71 527 7361
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Gold nano-antennas reveal single molecules’ electrochemical properties
Individual molecules are extremely hard to see through feeble fluorescence. Tiny gold nanorods serve as new antennas to intensify their signal 500 times. Publication on 24 February in Angewandte Chemie.
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Targeting the immune system to inhibit atherosclerosis
A new treatment for atherosclerosis showed promising results in isolated cells but proved to be less effective in initial animal tests. Bachelor student Biopharmaceutical Sciences Willemijn van der Heijden aimed to understand why. She investigated whether the formation of a protein layer around the…
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Publications
Recent publications
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Platinum electrochemistry through a magnifying glass
In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.
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Sander van Nielen
Science
s.s.van.nielen@cml.leidenuniv.nl | +31 71 527 2727
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Research
Research at the MCBIM group is comprised of the following research themes:
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Fundamental Research in Energy & Sustainability
Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…
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NWO Projectruimte for physicists Schalm and Zaanen
NWO has awarded a €392k Projectruimte grant to physicists Koenraad Schalm and Jan Zaanen to study ‘strange metals’. These materials are alleged to follow the bizarre laws of quantum mechanics even at everyday length scales.