2,343 search results for “modelling 26 simulations” in the Public website
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predictive pharmacology in children using semi-physiological population modelling: application to hepatic metabolism
Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…
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New generation galaxy formation simulations on the horizon – Evgenii Chaikin received his doctorate with honours
Simulations of galaxy formation provide much more information about galaxies than a telescope. Simulations have been improving significantly in recent years. Astronomer Evgenii Chaikin made such a significant contribution to this field that he graduated with honours on February 27th.
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A PCAD-model for fish to study the impact of airgun sound exposure on free-ranging cod
We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.
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distribution affects permeability barrier function of stratum corneum lipid model membranes
Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463
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Metals in the diffuse gas around high-redshift galaxies
Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)
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distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Xining Yang
Science
x.yang@cml.leidenuniv.nl | +31 71 527 2727
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Franz Wurm
Faculteit der Sociale Wetenschappen
f.r.wurm@fsw.leidenuniv.nl | +31 71 527 2727
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Suiting Ding
Science
s.t.ding@cml.leidenuniv.nl | +31 71 527 5615
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‘Scientists should be careful when interpreting results of AI models’
Anthropologist Rodrigo Ochigame studies how AI is changing the practice of scientific research. From astrophysics to mathematics to climate science, they find that the adoption of new AI models is raising questions about what counts as reliable scientific evidence.
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A+ for Leiden astronomy student who simulated chaotic interactions of black holes
Leiden astronomy Master's student Arend Moerman has received an A+ for his thesis research on the simulation of chaotic interactions of three black holes. The simulations, which he carried out together with his Leiden and Oxford colleagues, show that lighter black holes tend to slingshot each other…
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Roy de Kleijn
Faculteit der Sociale Wetenschappen
kleijnrde@fsw.leidenuniv.nl | +31 71 527 3915
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Fenying Zang
Faculteit der Sociale Wetenschappen
f.zang@fsw.leidenuniv.nl | +31 71 527 2727
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Tales Yamamoto
Science
t.m.yamamoto@cml.leidenuniv.nl | +31 71 527 2727
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Zsuzsa Bakk
Faculteit der Sociale Wetenschappen
z.bakk@fsw.leidenuniv.nl | +31 71 527 8032
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Towards a working model of industry and higher education collaboration in enhancing engineers’ soft skills for better employability
The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.
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Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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FOM Grant for Theoretical Model Majorana Gun
Professor Carlo Beenakker has been awarded a FOM Projectruimte subsidy to build a theoretical model of a majorana gun, a very promising instrument for quantum computers.
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Software and data for circular economy assessment
This thesis investigates how the assessment of circular economy (CE) at the macro-economic level can be facilitated and promoted.
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Stadium wave in the nerves: a new mathematical model
Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…
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SMALL Savannah : an information system for the integrated analysis of land use change in the Far North of Cameroon
Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan
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Applications of topology to Weyl semimetals and quantum computing
This thesis covers various applications of topology in condensed matter physics and quantum information.
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Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…
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'I am interested in how we simulate ourselves into the future'
It is a known trait in humans to anchor innovations in the past, so as to make new developments easier to accept. It is an aspect of humanity that can also be spotted in classical and prehistoric times. Archaeologist Daniel Turner will investigate the anchoring of monumental building in Greek Prehistory…
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History of Leiden University
Read on these pages all about the history of Leiden University, the oldest university in the Netherlands. The Academia Lugduna Batava was founded in 1575 and its motto is: Libertatis Praesidium ('Bastion of Freedom').
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Graduate School of Science
Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.
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Pasteurs Cube: a new model for classifying academic researchers?
Applying a three-dimensional framework of research-related activities, Pasteur’s Cube helps to describe and study ‘use inspired’ academics at today’s research-intensive universities.
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Fewer errors in software features by using delta modelling
When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…
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Algant Consortium meetings in Leiden 23-26 February
On Saturday 23 and Sunday 24 February, the yearly ‘Algant doctorate candidates and academics’ meeting will take place. The Algant Consortium consists of 8 universities on 4 continents and offers a two-year integrated master and a joint doctorate programme in pure mathematics, with a strong emphasis…
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Interactive models: Matthijs van Leeuwen receives NWO TOP grant
Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Novel system-inspired model-based quantum machine learning algorithm for prediction and generation of High-Energy Physics data
Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.
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'This course is a simulation of your professional work as an astronomer'
What if I completely changed everything? A subject without lectures or exams, where the right answer is not important and where students work with their hands. With this idea, Michiel Brentjens reformed the course Radioastronomy. His students are so enthusiastic about this approach that they nominated…
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Founding father of pharmacological models
After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.
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Leiden: The scene of the Zebrafish Disease Models conference 2018
In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Tom O'Brien
Science
obrien@lorentz.leidenuniv.nl | +31 71 527 5568
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Tessa Verhoef
Science
t.verhoef@liacs.leidenuniv.nl | +31 71 527 7903
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Ramira van der Meulen
Science
a.van.der.meulen@liacs.leidenuniv.nl | +31 71 527 2727
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Galaxy formation traced by heavy element pollution
Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.
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Course: Introduction to Ancient Egypt (7-26 May, 2018)
Do you live in Egypt and have you always wondered about all the pharaonic heritage surrounding you? This spring NVIC organizes a beginner’s level, introductory course in Egyptology. In 6 richly illustrated lessons, the history of ancient Egypt will be brought to life, both chronologically as well as…
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QS rankings: Law at Leiden ranked 26 worldwide
The results of the QS World University Rankings by Subject 2019 were announced last week. Law at Leiden has achieved 26th place of this worldwide ranking. It is the highest ranking for law programmes in the Netherlands.
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using population pharmacokinetic and physiology based pharmacokinetic modeling approaches
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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These researchers turn mathematical models into healthcare solutions
Two Leiden researchers have demonstrated how mathematics can improve our healthcare. Daniel Gomon has developed a model that contributes to the quality of care in hospitals. Marta Spreafico works on an app that helps physicians make well-informed decisions about the treatment of a certain type of cancer.…
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Sebastiaan Deetman
Science
s.p.deetman@cml.leidenuniv.nl | +31 71 527 5616