What role play stress and fear in forming of nocebo hyperalgesia?

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

Het Center for Interdisciplinary Placebo Studies Leiden (IPS) streeft naar een beter begrip van placebo- en nocebo-effecten, hun onderliggende mechanismen en hun mogelijke toepassingen in de klinische praktijk. IPS bestaat uit een groep interdisciplinaire onderzoekers die werken aan de Universiteit…

The placebo effect was completely new to her when Lingling Weng began the PhD project in Leiden. She is now a postdoc in China. 'It would be great to investigate the underlying mechanisms of placebo and nocebo effects with my current knowledge of EEG and fMRI.' PhD defence on 17 October.

We are confronted on a daily basis with news about the Corona virus and its consequences. We read alarming headlines like 'Dutch becoming increasingly anxious about Corona virus' or 'Huge fears and stress about Corona crisis'.

We aim to create an innovative e-learning and virtual reality training that helps healthcare providers to optimize placebo effects and minimizes nocebo effects via their communication.

The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

While many healthcare professionals indicate that they frequently use placebo effects and their mechanisms, there is little formal training on how to deal with placebo and nocebo effects in clinical practice. This project aims to address this gap between scientific knowledge on placebo and nocebo effects…

Positive expectations can influence sensations of itch and evoke placebo effects, whereas negative expectations can trigger nocebo effects in itch. There is evidence that placebo effects can occur even when people know that they are taking a placebo. Little is known about how these so-called open-label…

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

Four Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Academic Research (NWO).

PhD defence

Health psychologist Andrea Evers is one of the 19 new members, selected by the Royal Netherlands Academy of Arts and Sciences (KNAW), who have been inaugurated on 16 September 2019. The Academy has now about 550 members.

Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…

PhD defence

Andrea Evers, Professor of Health Psychology at Leiden University, has won the Stevin Prize – alongside the Spinoza Prize, the highest scientific award in the Netherlands. She is the third social scientist from Leiden in a row to win one of these prizes. ‘Leiden attracts freethinkers.’

Positive expectations about a medicine may help it to work more effectively, even if you tell patients about this placebo effect. The reverse, the nocebo effect, works in the same way. Health psychologist Stefanie Meeuwis found evidence for this in various studies. PhD defence 3 June.

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Positive expectations about treatment increase the likelihood of success. The new Center for Interdisciplinary Placebo Studies Leiden is therefore promoting research on the placebo effect and offering expertise and training for care providers. At the opening, the founders demonstrated their VR communications…

From painful joints to intense fatigue: a third of rheumatism patients suffer serious effects from this chronic condition and rely long-term on medication. Leiden psychologists are to receive a subsidy from the Netherlands Arthritis Foundation to investigate whether placebo techniques can help patients…

If a pill containing no active ingredients still helps, this positive expectation is called a placebo effect. A negative expectation is called a nocebo effect. Both can be produced by verbal suggestions and conditioning. According to Andrea Evers’ research group, combining these is the most promising…

If you expect something is going to itch, the itching really does get worse. Leiden health psychologist Danielle Bartels has proved the effect of negative expectations on itching. What’s remarkable is that this nocebo effect in itching can be reversed. ‘That offers good prospects for clinical practice,’…

It is becoming increasingly clear that the placebo effect has a great influence on medical treatment. An international, interdisciplinary team of researchers led by Professor of Health Psychology Andrea Evers from Leiden University has now written a first set of guidelines on how to apply the placebo…

The Royal Netherlands Academy of Arts and Sciences (KNAW) has granted health psychologist Andrea Evers a visiting professorship funding for Luana Colloca. This funding is linked to the KNAW’s Visiting Professors Programme which enables outstanding foreign researchers to spend time working in the Netherlands.…

Medicines can work even if they have no active ingredient. The first international scientific conference on placebos will take place in Leiden from 2 to 4 April. Placebo researcher Andrea Evers, who is also chairing the conference, answers some pressing questions.

Janna Marie Bas-Hoogendam, Stefanie Meeuwis, and Eliška Procházková have all been awarded a share of the Aspasia diversity grant obtained by Mariska Kret. These three promising young psychologists will each receive 10,000 euros as a stepping stone towards a career in science. This gives them three months…

Andrea Evers is the new Professor of the brand-new unit of Health, Medical and Neuropsychology. She's getting off to a flying start in Leiden with a consolidator grant of the European Research Council (ERC). Her ambition? 'To work together with other disciplines; that way we can arrive at new insigh…

Sometimes fake medicine is enough to cure a patient. But how exactly do placebos work? And did you know that there is also the placebo effect in reverse, the nocebo effect? Psychologist Stefanie Meeuwis explains in this Science Shot.

Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…

Leiden University will be recording a brand-new series of podcasts in 2019: Science Shots. Our top scientists will talk about their research in less than 15 minutes. Tip: something to enjoy on the train journey between Leiden and The Hague, our two University cities!

The tuk-tuk of the European City Of Science Leiden 2022 sent science on its way to the neighbourhood. On the Vijf Meiplein in Leiden, Andrea Evers' placebo team pitched its tent to everyone who wanted to know more about the effect of words and expectations. Experience the day of the placebo effect in…

During the 2019 Health, Medical and Neuropsychology Christmas lunch, several staff members and research (student) assistants were awarded.

Leiden health psychologist Liesbeth Van Vliet receives recognition for her research on doctor-patient communication and its influence on quality of healthcare. Van Vliet has been awarded one of four Heineken Young Scientists Award 2022 for promising young researchers working in the Netherlands.

LUF grants for research projects have been awarded to Liesbeth van Vliet, Michiel Claessen, Anna van Duijvenvoorde, Laura Steenbergen, Kim de Jong and Franziska Richter. Each of these Leiden University scientists receive an amount between € 17.500 and € 25.000 to realise their scientific plans.

The Institute of Psychology is committed to play a prominent role in teaching and research at the national and international level.

PhD defence

Lecture