Soil bacteria can produce a wealth of antibiotics that are new to us, claims Gilles van Wezel, Professor of Molecular Biotechnology at the Institute of Biology Leiden. His research group has developed a method that can rapidly identify and produce these unknown compounds.

Gubbens

For a first time the atlas maps the soil biodiversity of the entire planet, and provide s comprehensive analysis of human-induced threats to soil organisms and soil functioning, facilitating development of new policies to protect soil and soil organisms.

How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

What are the principles of genome folding and dynamics in bacteria?

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

How do nonmotile microbes leverage communal motility?

We examine how soil-derived legacy effects of plants structure natural ecosystems, determine aboveground plant insect interactions, and how we can use soil legacy effects to restore degraded ecosystems.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Archaeobotanic research by prof. dr. C. Bakels and students on agriculture.

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

Bacteria use antibiotics as a weapon and even produce more antibiotics if there are competing strains nearby. This is a fundamental insight that can help find new antibiotics. Leiden scientists Daniel Rozen and Gilles van Wezel published their research results in the authoritative Proceedings of the…

We examine how soil inoculation influences aboveground organisms (i) directly, and indirectly via (ii) its effects on plant chemistry or volatile emission, or via (iii) mediating the effects of belowground pathogens on aboveground organisms via the shared plant.

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Plants love favourable microbes such as bacteria and fungi: they grow better and become healthier. Jos Raaijmakers, Professor of Microbial Ecology, is in search of the right microbes to be used in agriculture. Inaugural lecture 13 November.

Soil ecologists Emilia Hannula (Leiden) and Elly Morriën (UvA) received the Golden Medal of Teylers Tweede Genootschap on 5 November. They received the prize for their submission to a competition on sustainable soil management.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

Imagine that you need to travel, but you don’t have a car and you’re dead broke. What do you do? Hitchhiking, of course! Leiden biologists found that certain bacteria use this very same tactic: their spores hop on motile bacteria and use them as a taxi, ensuring they reach the right environment to f…

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Bacteria found in soil specialise in the colony by division of labour. Some of the bacteria produce antibiotics, even when it comes at the expense of their individual reproduction success, to defend their colony against competitors. Publication in Science Advances.

Leaf-eating caterpillars greatly enrich their intestinal flora by eating soil. Even effects of plants that previously grew in that soil can be found back in bacteria and fungi in caterpillars. Researchers from the Netherlands Institute of Ecology (NIOO-KNAW) and Leiden University write about this discovery…

In an unpredictable environment bacteria evolve the same strategy as shareholders who try to protect themselves against unpredictable swings in the stock market. Experimental evolution biologist Dr Bertus Beaumont published an article on this discovery on 5 November in the journal Nature.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

How do bacteria sense and adapt to their environment? Ariane Briegel, Professor of Ultrastructural Biology, is intrigued by this question. Using new techniques, she produces three-dimensional images of bacteria that provide us with new clues about their sensory system.

Bacteria and fungi on organic dairy farms are significantly different from those on conventional farms. That was discovered by postdoc researcher Sofia Gomes and her supervisors Nadia Soudzilovskaia and Peter van Bodegom in collaboration with the Louis Bolk Institute and Naturalis Biodiversity Centre.…

Ariane Briegel wants to use bacteria to detect cancer at an early stage. Together with postdoc Alise Muok, she is developing a method to quickly and cheaply test the urine of patients for the presence of suspicious molecules. They receive a grant of approximately 150,000 euros from the Dutch Cancer…

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom