The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Many of the most acute problems we face today are global: they transcend national boundaries, they put the future of society and even humanity at peril, and they can only be addressed through international cooperation. However, what can international cooperation deliver? Find out in the minor Ecology,…

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…

When we think of politics, we tend to think of adversary, antagonism, polarisation, a struggle for power. But politics should serve positive purposes, as well. Political psychologist and meditation teacher Femke Bakker (Leiden University) thinks that positive politics is first and foremost about tolerance.…

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

This new article by Monica Kaminska is part of a special issue for Journal of Cybersecurity, based on a selection of contributions from THe Hague Program for Cyber Norms' 2019 Conference.

The idea that modern humans displaced Neanderthals because they were better protected against toxic smoke components is now under fire. An earlier study that put forward this suggestion has now been refuted by genetic research by scientists from Leiden and Wageningen. This new research was published…

Bastiaan Rijpkema has been appointed Professor by special appointment of the new chair Tolerance at the Faculty of Humanities with effect from 1 July 2021. The chair was established by Stichting Leerstoel Uytenbogaert.

The Upper and Lower Houses of the Dutch Parliament are struggling with how tolerance should best be interpreted. As a result, the freedom in the Netherlands for people who hold alternative views is diminishing. This is Floris Mansvelt Beck’s conclusion on the basis of his PhD research. Defence on 2…

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Everything you need to know about the minor Ecology, Migration and Tolerance: Limits to Cooperation.

Manon van der Heijden and Leo Lucassen, and Maarten Mous will receive NWO Open Competition funding. This funding amounts to a maximum of 750,000 euros and is intended to carry out research into a subject of their your own choice, without thematic preconditions.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

The nineteenth century truly was an age of transformation. Throughout Europe processes of industrialization and urbanization, nationalization and centralization, changed the structures of society. It was an age in which the number of people living in urban communities grew substantially.

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

This study describes religion in Java.

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Due to its economic prosperity, its policy of (relative) religious tolerance, and its large numbers of migrants, the Dutch Republic has long had a reputation of being the prime example of ‘tolerance’, especially during the seventeenth century. Although the great variety of newcomers in the Dutch Republic…

Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?

Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Linda Stuckrath Gottschalk defended her thesis on 6 April 2016.

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh

Key publications of the Biologics Formulation group

The rise and fall of Dutch Brazil (1624-1654) was a major news story in early modern Europe, and marked the emergence of a

Ilina Georgieva published an article in the journal Contemporary Security Policy on the norm-setting role of intelligence agencies.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.