141 search results for “aggregates” in the Public website
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Planning for a World beyond COVID-19: Five Pillars for Post-Neoliberal Development
In this opinion article published in World Development, the authors present five research and policy priorities. While it is clear that ‘pluriversal’ designs need to guide the way forward (Kothari et al 2019), defining a set of key pillars can provide direction and purpose across this pluriversality.…
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Enhancing access to EU law: Why bother?
In the past years access to EU law has been significantly enhanced via services such as EUR-Lex. This development not only allows for easy retrieval of individual legal acts, but for collecting information about the evolution of EU law in the aggregate as well.
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SDS-PAGE at the nanoscale: A nanorecorder for single molecule protein sequencing with graphene
Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?
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The town, its waste and the cesspit
The rise and fall of the cesspit in an urban context
- Governing Digital Platforms
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Open Data: The Researcher Perspective
Combining results from bibliometric analyses, a global sample of researcher opinions and case-study interviews, a new report reveals that although the benefits of open research data are well known, in practice, confusion remains within the researcher community around when and how to share research…
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China’s industrial carbon emissions: Historical drivers at the regional and sectoral levels and projections in light of policy targets
Has the industrial sector in China effectively been decarbonizing in recent years, across different regions and subsectors, and is it plausible that it will reduce its CO2 emissions in conformity with national and internationally pledged emission goals?
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Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
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Key publications
Key publications of the Medical Systems Biophysics and Bioengineeringgroup (Mashaghi Lab)
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The Archaeology of the First Farmer-Herders in Egypt
New insights into the Fayum Epipalaeolithic and Neolithic.
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Bachelor Projects
Bachelor projects are available in
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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How an Alzheimer related protein forms plaques
Neurological diseases, such as Alzheimer's disease, are characterised by aggregates of protein in the brain. The connection of these aggregates to the disease itself is unclear. Martina Huber, Enrico Zurlo and colleagues published a new method to monitor the formation of these aggregates.
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Links
Links to various Digital Humanities organizations and resources, mainly in English.
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Kraft Lab - Self-assembly in Biological and Soft Matter
Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.
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Pesticides Atlas overhauled in line with European Framework Directive on Water
The Dutch atlas with pesticides concentrations in surface waters have been overhauled. This new, free accessible, website is in line with the European Framework Directive on Water (In Dutch: KRW).
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Plenary speakers
We’re delighted to announce our plenary speakers.
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Scientific computing for Drug Discovery in Python and/or R
Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.
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Alireza Mashaghi Tabari
Science
a.mashaghi.tabari@lacdr.leidenuniv.nl | +31 71 527 4425
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How cells determine the fate of proteins (and can we do it too?)
Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…
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“Kees Bakker" award for Bregje Brinkmann
Leiden Biology student Bregje Brinkmann received the annual award for being the best BSc-student in 2014 from the “Stichting Professor Dr. K. Bakker-fonds”.
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Vidi grants for eight researchers from Leiden University
Eight scientists from Leiden University have been awarded a grant by the Dutch Research Council (NWO). With this Vidi funding, the researchers can set up an innovative line of research and further expand their own research group over the next five years.
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Moralising Misfortune: A comparative anthropology of commercial insurance
Research on the morality of life insurance. What issues are raised when insurance companies define responsibility and solidarity? Has insurance changed since the crisis of 2007?
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Data protection and privacy
At Psychology Lab on Wheels, we take your privacy and the security of your personal data very seriously. We want to assure you that all the information collected during this study will be handled in accordance with the General Data Protection Regulation (GDPR).
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Home sweet home
Investigating Neolithic houses in Britain through microwear and residue analysis of stone tools
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Urban
Urbanization brings benefits like housing and jobs but also challenges like biodiversity loss. CML's Urban research program uses science to create sustainable cities, focusing on the built environment (circular economy, urban mining) and enhancing urban nature for biodiversity and human benefits.
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International Symposium on Circuit Topology Organized by Leiden University
For the third consecutive year, LACDR organized the international symposium on topology, Circuit Topology III, on November 29, 2023. The event aimed to bring together experts from diverse fields, including mathematics, computer science, physics, chemistry, and biomedical sciences, to discuss cutting-edge…
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Daniela Kraft wins Biophysical Journal Paper of the Year Award
The editors of Biophysical Journal have selected a publication from Daniela Kraft’s group as the Paper of the Year 2017. The award recognizes an outstanding contribution by a young investigator.
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Can Parkinson's be stopped by unravelling protein fibres? Anne Wentink finds out with a Vidi grant from NWO
In brain diseases such as Parkinson's and Alzheimer's, proteins clump together to form fibres. ‘Chaperone proteins’ unravel those fibres, but in the test tube biochemist Anne Wentink saw that this can also cause new problems. She is going to find out what happens inside cells to determine what a drug…
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Human Rights and Climate Change: Call for Abstracts
On 27-28 January 2022, Leiden University’s interdisciplinary seed grant programme ‘Beyond Anthropocentric Interests and Values? Human Rights and Climate Change’ will host a conference on human rights and climate change. Researchers are welcome to join and contribute their view. The deadline for the…
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Attacking tuberculosis bacteria: an interview with Mónica Varela
This summer postdoctoral researcher Mónica Varela from the Institute of Biology Leiden was awarded a Veni grant from the Dutch Research Council (NWO). Six questions about her project and hopes for the future.
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Books for Review
The Hague Journal of Diplomacy regularly publishes book reviews of approx. 800-1000 words, upon invitation by our Book Reviews Editor. We are currently accepting reviews of the selected books below, as well as any other contribution within the field of diplomacy and global affairs.
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International media report on Leiden dosage app for corona patients
Coen van Hasselt's research group quickly produced an app that enables doctors to determine the correct dosage of commonly used medicines for corona patients. Media in the Netherlands and abroad reported on the app.
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GTGC lunch seminar: human rights for governing digital platforms
On Monday 9 October 2023, Jelena Belic, Matthew Canfield, Rachel Griffin, Henning Lahmann, and Barrie Sander presented their research on 'The Promise and Perils of Human Rights for Governing Digital Platforms' during a GTGC lunch seminar.
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Training
As a PhD candidate, you are expected to follow certain courses and training programmes in the context of your training as a researcher. The courses and training programmes will help you conduct your research, write your dissertation, develop your career, and gain self-insight. The LACDR PhD training…
- Publication highlights
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Departments
Leiden Asia Departments
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Leiden Observatory comet research goes viral
From Mexico and Indonesia to China and Italy: people from all over the world read about the Leiden Observatory publication on the birthplace of comets. This research suggests that all comets in our solar system might come from the same place: a specific range in the flat disk of dust and gas that once…
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Reading through proteins with graphene: NWO Vidi grant awarded to Dr. Grégory Schneider
While there are numerous and extremely advanced methods to sequence the genome, only a few methods exist to sequence the proteome. The Vidi project of Grégory Schneider promises to shed light on the most difficult paradigm of proteomics: achieving an error-free determination of the sequence of single…
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Wessel Kraaij appointed Professor of Applied Data Analytics
Wessel Kraaij has been appointed Professor of Applied Data Analytics with effect from 1 March 2016. Kraaij will use new methods to analyse big data sets. He intends to use data from various data-intensive research fields to test these methods in practice.
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Biological Origami at molecular level: folding a single protein
Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…
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Unraveling the mysteries of Multiple Sclerosis
Leiden chemists discovered a new mechanism which might explain how multiple sclerosis shifts to a more severe form. Their findings contribute to unravelling the mysterious course of the disease. They have published their findings in the journal Biochemistry.
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MOOC Public Administration one of the best courses 2020
The Massive Open Online Course (MOOC) ‘EU policy and implementation: making Europe work!’ of Public Administration is included in the list of Class Central of the best courses in 2020.
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Ewine van Dishoeck receives honorary doctorate from the University of Geneva
Astrophysicist Ewine van Dishoeck has been awarded an honorary doctorate from the University of Geneva. She received the award on 11 October during the Dies academicus of the Swiss university, which, like Leiden University, is part of the European research university federation LERU.
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Pristine cometary dust under the microscope
An international team of researchers with Pascale Ehrenfreund from Leiden University has discovered that the dust particles of comet 67P/Churyumov–Gerasimenko are made up of even smaller particles. This discovery confirms that clumps of dust form the basis for comets and planets.
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Localising global garment biographies
Discover the effects of clothing value and lifespan on buyer-user-producer relationships through collaborative research with Localising Global Garment Biographies.
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Governing Polarized Societies (GPS)
Having encountered a series of shocks that pose an existential threat to our livelihoods, our societies have become increasingly polarized. Shortly after two years of lockdowns due to the pandemic, the war in Ukraine boosted at a global scale a polycrisis that intersects energy shortages, refugees,…