Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.

Microbial Sciences' contribution to the Host-Microbe Interactions research theme is to investigate how beneficial or disease-causing microbes associate and interact with their host.

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…

Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?

The overall aim of this project is to understand, on the molecular level, how the bacterium V. fischeri cells interacts with their squid host.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

How do nonmotile microbes leverage communal motility?

We examine how soil-derived legacy effects of plants structure natural ecosystems, determine aboveground plant insect interactions, and how we can use soil legacy effects to restore degraded ecosystems.

How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

Which plant leaf characteristics are involved in thrips resistance in tomato?

We examine how soil inoculation influences aboveground organisms (i) directly, and indirectly via (ii) its effects on plant chemistry or volatile emission, or via (iii) mediating the effects of belowground pathogens on aboveground organisms via the shared plant.

What is the function of the insect serosa?

Why do plants produces always produced so many slightly differing metabolites within a particular chemical class?

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

What is the connection between materials with weak and strong gravitational interactions?

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.

How do mycobacteria subvert the defenses of host immune cells?

Efficient gene-targeting during meiosis

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

How can Staphylococcus aureus bacteria subvert the host immune system?

What is the role of cell wall-deficiency in the persistence of tuberculosis?

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

Intimate Legal Interactions (ILI) is an interdisciplinary and international group of scholars who share an interest in laws governing intimate relationships – such as marriage and civil partnership, divorce, birth, death, parenthood, childcare, sexual/romantic relationships, and caring relationships…

How does global change across time and space lead to convergence and loss of variation or increasing diversity and conflict?

How do social and political developments influence the process of meaning-making in different parts of the world? Why is a particular discourse interpreted in numerous ways depending on the context it is produced and propagated? And how are culture, politics, history, and language intertwined?

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

Fostering multi-polar perspectives that engage more connected, nuanced and pluralistic understandings of the world. Global Interactions encourages and supports research that provides significant new insights on these global processes across time and space.

Media & interaction is where artificial intelligence and machine learning meet philosophy, cognitive science, and the creative arts. Examples of research questions in this domain are: 'Can an algorithm be creative by human standards?', 'Can creative processes, such as composing music or writing poetry,…

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Media & interaction is where artificial intelligence and machine learning meet philosophy, cognitive science, and the creative arts. Examples of research questions in this domain are: 'Can an algorithm be creative by human standards?', 'Can creative processes, such as composing music or writing poetry,…

Utilization of plant-originated products as new antibiotics

The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.