163 search results for “drug discovery” in the Student website
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CCLS Seminar
Lecture, Center of Computational Life Sciences
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‘Ultimately, the goal is to develop antibiotics for tuberculosis with a lower risk of resistance’
Tuberculosis stands as one of the most lethal infectious diseases worldwide. A significant challenge in combatting tuberculosis lies in the emergence of antibiotic resistance triggered by genetic alterations, commonly known as mutations. These mutations can diminish the responsiveness to antibiotics,…
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Rob van Wijk
Science
r.c.van.wijk@lacdr.leidenuniv.nl | +31 71 527 4505
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Leiden researchers join forces against tuberculosis
About one and a half million people worldwide die each year from tuberculosis. For thirty years, therapy with antibiotics has been the same, while it takes far too long and can lead to resistant pathogens. Leiden researchers from four institutes are now joining forces to develop more effective and efficient…
- Courses
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Farewell symposium Prof. dr. Joke Bouwstra
Valedictory lecture
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Remarkable PhD research: diagnosing sepsis in premature babies
How can we diagnose the life-threatening condition sepsis in premature babies as quickly and accurately as possible? That is what PhD student Manchu Thangavelu from the Leiden Academic Centre for Drug Research (LACDR) wants to figure out.
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With this algorithm, new medicines can be found more quickly
Did he dare take a gamble with his PhD research? Jeroen Methorst didn’t have to think long about it. It could fail or turn out very well. The latter is the case. Methorst developed a computer system that helps researchers find the protein they need. ‘Our whole group is now using this program.’ Methorst…
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Ecologist Michiel Veldhuis is the Discoverer of the Year 2020
Michiel Veldhuis received the most public votes for the C.J. Kok Public Award and may therefore call himself Discoverer of the Year. Veldhuis researches how climate change affects savannah ecosystems in Africa and how we can protect them.
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New protein inhibitors against cancer? Unilever Research Prize for Aukje Beers
Aukje Beers combined theory and practice, as well as chemistry, biology, and computer models. In this way, she discovered two protein inhibitors during her master’s project that could contribute to the development of a new cancer drug. For her research, Beers received the Unilever Research Prize on…
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Scouring the brain for causes of psychiatric illnesses
What happens in the brains of people with psychiatric illnesses? With a €23.23 million gravity grant, scientists from different fields will search for biological causes over the next decade. ‘By joining forces, we hope to improve diagnosis and treatment for patients with these diseases.’
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Be amazed and inspired during the Leiden Science Family Day!
On Sunday 8 October 2023, during the Weekend van de Wetenschap, the Faculty of Science of Leiden University will open its doors to anyone curious about science from 11.00 to 16.00 hrs! Explore a world of wonder and discovery; where science is transformed into an unforgettable adventure. Intriguing…
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€10.6 million for innovative toolboxes to tackle brain cancer
Researchers at the Universities of Amsterdam (Uva) and Leiden together with the Netherlands Cancer Institute and Oncode Institute have received a €10,6 million ERC Synergy Grant to develop innovative therapeutic approaches to target glioblastoma. This is a deadly primary brain tumour for which no curing…
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Nienke van der Marel receives New Horizons Prize
Nienke van der Marel has been awarded the New Horizons Prize in physics for her pioneering research on planet formation. This prize is given to young, promising researchers in physics or mathematics. The astronomer and her colleagues found the first observational evidence for 'dust traps' in disks around…
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Radio astronomers bypass disturbing Earth's atmosphere with new calibration technique
An international team of researchers led by astronomers from Leiden University (the Netherlands) has produced the first sharp radio maps of the universe at low frequencies. Thanks to a new calibration technique, they bypassed the disturbances of the Earth's ionosphere. They used the new method to study…
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Atherosclerosis resembles an autoimmune disease. Marie Depuydt graduated on this topic, with honours
In addition to cholesterol and high blood pressure as risk factors for atherosclerosis, we may need to address our own immune system to prevent a heart attack or stroke. Marie Depuydt revealed which cells exactly reside in the atherosclerotic plaque that narrows an artery. The presence of a diverse…
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Fighting gliobastoma brain tumours with two grants
Few researchers see potential in research on glioblastoma, an incurable brain tumour. Alexander Kros brought together colleagues who are up to the challenge. European research funder ERC recently made 10.6 million euros available, a year earlier NWO provided 3 million euros. ‘In six years, we certainly…
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Better treatment of skin diseases thanks to NWA grant of 11.7 million euros
Patients with skin diseases such as eczema and psoriasis, sometimes spend a lifetime searching for the right medication. To help these patients faster and better, scientists across the country are joining forces. The Next Generation ImmunoDermatology (NGID) project, with LACDR professor Robert Rissmann…
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Planet found too big for its parent star
The discovery of a planet far too large for its sun defies models about the formation of solar systems and planets. In a paper in Science, researchers, including Yamila Miguel of Leiden Observatory, report the discovery of a planet more than 13 times heavier than Earth orbiting the ultracool dwarf star…
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Black holes are sometimes gigantic volcanoes. Martijn Oei earned his PhD on the subject, with honours
Not everything that comes close to a black hole is swallowed by it. Black holes can also hurl material away, and that chance turns out to be considerably bigger than previously thought. Martijn Oei's accidental discovery and his subsequent research on it earned him a cum laude promotion on 12 Decemb…
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What was there first? Water or planets?
Could water be present in planet-forming disks before the formation of rocky planets? The James Webb Space Telescope may have found evidence for that. Webb has for the first time observed water in the inner disc around young star where at greater distance, giant planets have already formed. The research…
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NEW – Tuesday Talks: Science Insights
Organisation, Research, Social
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Visit by Members of Parliament highlights interdisciplinary research and collaboration
High-quality education, research involving multiple faculties, collaboration between universities and central government funding to make all this possible: these were the topics covered in a working visit of the Standing Committee for Education, Culture and Science (OCW) to the Association of Universities…
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'If you think astronomy is a man's world, then it's your job to make a change'
During her master's thesis, Nashanty Brunken (24) worked in a team with five other women. With this female team, they discovered the largest molecule so far identified in a disc. 'I have learned so much and because we are all women, it is incredibly empowering. It's very cool to see how far we've come…
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Scientific breakthrough: evidence that Neanderthals hunted giant elephants
Neanderthals were able to outwit straight-tusked elephants, the largest land mammals of the past few million years. Leiden professor Wil Roebroeks has published an article about this together with his German colleague Sabine Gaudzinski-Windheuser in the Science Advances journal.
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First Tuesday Talks is a fact: 'It's nice to learn something from another field'
He had been back from Australia for less than 48 hours, but there was no sign of that. Michel Mandjes of MI had the honor of kicking off the very first Tuesday Talks: Science Insights on Tuesday. He did so with a presentation on complex networks.
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Improving nature’s antibiotic
'What nature made isn’t necessarily an optimized medicine to use in the human body,’ says Professor of Biological Chemistry Nathaniel Martin. That’s why a group of Leiden researchers is making a chemistry-based improved version of the frequently used antibiotic vancomycin. They received an NWO NACTAR…
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Study associations sign covenant: limit your alcohol consumption and look after each other
Opting more often for mocktails or soft drinks rather than beer or wine, talking to others about their drinking and pointing out the ban on drugs. Leiden University’s new covenant on alcohol and drugs for study associations encourages providing more alcohol-free alternatives.
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Sibel Bahtiri is one of the new Faces of Science: ‘I want to show how we’re finding alternatives to animal testing’
PhD candidate Sibel Bahtiri is one of the new Faces of Science. In videos and blogs, she will show what life is like as a young researcher.
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With 30 million dollars, this consortium aims to tackle tuberculosis
Thanks to a clever research method, progress is being made in the quest for better tuberculosis medications. Within an American consortium that received a 30 million dollars grant, Leiden researcher Rob van Wijk plays a significant role. ‘The next breakthrough in tuberculosis research will come much…
- Consent is key
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Support for your well-being
Good mental health provides a strong foundation for study and work. It is important to seek help if you are not doing well. There are a range of ways in which you can work on your mental well-being. You can also turn to others for help and guidance. Take a look at the various options available.
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CSC-Leiden University Scholarship
PhD
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Healthcare and insurances
Hopefully it won’t be necessary but should need to access healthcare during your studies, you can find all the necessary contact information here. Make sure you also have adequate health insurance. This is a legal requirement in the Netherlands. We also highly recommend that you take out liability i…
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Scientists discover the largest stellar black hole in the Milky Way
A European team of astronomers has discovered the largest stellar black hole in the Milky Way. It is more than thirty times as massive as our sun and is located in the constellation of Aquila, about two thousand light-years from Earth. The astronomers stumbled upon the black hole by chance while preparing…
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The Top 450 is growing: entry number 50 published
The 50th Top 450 entry has now been published. In the run-up to the university’s 450th anniversary, we are compiling our Top 450. What is your favourite?
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Combatting antibiotic resistance in a clever way
When you become very good at one thing, that sometimes comes at the expense of something else. Such trade-offs also apply to bacteria. When becoming more resistant to one antibiotic, bacteria can sometimes become more sensitive to another. Linda Aulin, PhD candidate in the pharmacology group of Coen…
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A lifeline for Leiden research – TB solution a step closer thanks to this Indonesian university
Herman Spaink knows of many substances that may help combat tuberculosis. Lab space to study them safely is very limited in Leiden. A brand-new lab at Universitas Gadjah Mada in Indonesia will soon provide a solution. About time, says Spaink, ‘The disease is on the rise and is becoming less sensitive…
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Mental health monitor for Leiden students reveals need for more action
Last month, research by the National Institute for Public Health and the Environment (RIVM) revealed that more than half of students in higher professional education and at universities experience psychological complaints and emotional exhaustion, and that a quarter of them suffer from anhedonia (loss…
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Reliable research with virtual patients
The right medicine in the right dosage for every patient, that is something medical science aspires. 'Personalised medicine' is the term for that. But it does require a lot of research with patient data and that can be hard to get due to privacy legislation. Researchers Laura Zwep and Coen van Hasselt…
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Antibiotic resistance: an economic problem universities could help to solve
Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.
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Multiple KHMW awards for science students
As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…
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Modified caffeine molecules help medical research move forward
Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable research into certain receptor proteins on cells.
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NWO-XS grants for two innovative research projects
Two Leiden Science researchers received an NWO-XS grant for their research. Both projects are highly promising, but also high-risk. Macrophages that trap bacteria and data storage made from 2D materials convinced the board of their potential.
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Webb data suggest potential atmosphere around rocky exoplanet
Researchers using NASA’s James Webb Space Telescope may have detected atmospheric gases surrounding 55 Cancri e, a hot rocky exoplanet 41 light-years from Earth. This is the best evidence to date for the existence of any rocky planet atmosphere outside our solar system.
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In 450 days... 450 years of Leiden University
In exactly 450 days’ time, on 8 February 2025, it is the university’s 450th anniversary. We are obviously going to celebrate this with our students, staff and friends. Do you have any ideas for this celebration?
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In memoriam Jan Zaanen 1957-2024: The universe in a speck of rusting copper
This Thursday, January 18th 2024, our esteemed colleague Jan Zaanen passed away. Jan was one of our star scientists, larger than life, with an unabashed, boisterous drive for the best of physics at the Institute Lorentz, at the Leiden Institute of Physics and in the full international scientific community.…
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Exhibition on Anton de Kom’s second life, which began in Leiden
Few people would associate the name Anton de Kom with Leiden. Yet the Surinamese freedom fighter is the subject of an exhibition at Museum De Lakenhal.
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Lowlands as lab: virtual trips in the name of science
While tens of thousands of visitors dance to deafening music, a team of Leiden psychologists are trying to collect data for their research at Lowlands. How do festivalgoers experience a virtual trip? And what role do factors such as too little sleep and whether they have experience with psychedelics…
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Improving safety assessment of nanoparticles
How safe are the nanoparticles in transparent sunscreen, anti-odour socks and bacteria-resistant plasters? Although microbes are present on all organisms, the tools that estimate the safety of nanomaterials still hardly take them into account. Bregje Brinkmann explored the role of these microbes during…