Universiteit Leiden

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Population Pharmacokinetic Modeling

Monday 21 October 2019 - Thursday 24 October 2019
Gorlaeus Building
Einsteinweg 55
2333 CC Leiden

Population Pharmacokinetic Modeling

With population pharmacokinetic (PK) modeling we describe the concentration-time profile of a drug in the body. An important aspect of population PK modeling is identifying sources of variability between individuals of a population and quantifying this inter-individual variability. In a subsequent covariate analysis, potential patient and treatment characteristics that can explain (part of) the inter-individual variability are investigated. Once we have a population PK model that can describe and predict both general trends in the PK of drugs and individual deviations from those trends, we can use model-based simulations to optimize drug dosing. With the simulations, we can identify characteristics that can put patients at risk for overdosing, leading to undesired side-effects, or underdosing, leading to therapy failure. The model-based simulations can then be used to individualize drug dosing recommendations for these patients, based on their characteristics.

Learning goals

After this part of the course, you will be able to:                

  • explain how PK processes are parameterized and how models are used to describe and predict concentration-time profiles
  • develop structural population PK models to describe the relationships between drug dosing and drug concentration.
  • identify and quantify inter-individual variability and covariate relationships in population PK models.
  • explain how covariates can be used to (partially) explain inter-individual variability in population PK models.
  • explain how model-based simulations can be used to optimize and individualize drug dosing regimen.
  • perform model-based simulations to optimize and individualize drug dosing regimen.

Required background knowledge

This course is intended as an introduction for those who wish to apply population modelling with NONMEM. No prior programming experience is required, prior knowledge of basis pharmacokinetic principles is useful. 

Course program

During this course the following subjects will be treated:

  • basic principles of population pharmacokinetic modelling
  • covariate modelling and development of individualize drug dosing regimen
  • hands-on experience with the following software: NONMEM and pirana (the latter also implementing Pearl-speaks-NONMEM (PsN) and R).


The course ‘Population Pharmacokinetic Modelling’ will be given on 21, 22, 23, 24 October 2019. At the end, each participant will make a final assignment on an individual basis, which will be assessed with a Pass/No-pass.

Who should attend

Researchers (postgraduate level) who want to obtain basic knowledge and skills regarding population pharmacokinetic analyses with NONMEM.

Credits – registration - location

Date: 21 – 24 October 2019

Location: Gorlaeus Laboratories, LACDR, Einsteinweg 55, Leiden

Course coordinator: Elke Krekels

This courses will give you 28 education hours (1 ECTS).

Participants are requested to bring their own laptop, but a NONMEM or Pirana/PsN installation is not required.

Course fee: (including official participation certificate, 4 lunches and coffee/tea breaks):

Academic fee                         €550,-

Industry fee                            €1250,-

Contact: e.krekels@lacdr.leidenuniv.nl

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