Lecture | seminar
- Tuesday 8 March 2022
- After the seminar, drinks will be served at the Science Club (@ Gorlaeus Lecture Hall, Einsteinweg 57)
- De Sitterzaal
Stefan Semrau is Associate Professor of Physcics at LION
Title: Phiclust: a clusterability measure for single-cell transcriptomics reveals phenotypic subpopulations
Abstract: The ability to discover new cell phenotypes by unsupervised clustering of single-cell transcriptomes has revolutionized biology. Currently, there is no principled way to decide whether a cluster of cells contains meaningful subpopulations that should be further resolved. In this presentation I will introduce phiclust, a clusterability measure derived from random matrix theory that can be used to identify cell clusters with non-random substructure, testably leading to the discovery of previously overlooked phenotypes.