PhD defence

Mathematical modelling of cellular pathways contributing to drug- induced liver injury

• E.J. Burgers

Date

Wednesday 8 July 2026

Time

11:30 - 12:30 hour

Address

Academy Building
Rapenburg 73
2311 GJ Leiden

Supervisor(s)

• dr. J.B. Beltman
• Prof.dr. B. van de Water

Summary

Drug development is a lengthy and costly process. Many drugs fail clinical trials despite extensive preclinical tests on animals. Drug-induced liver injury (DILI) is a common reason for drugs to fail clinical trials or to be withdrawn from the market. To improve the prediction of DILI, we need to understand its underlying mechanisms. In this thesis, we use ODE modelling to describe compound kinetics, downstream responses within various stress response pathways, interactions between these pathways, and their effects on cell fate. In this way, we intend to increase our mechanistic understanding of these processes and to progress the development of new methods for DILI predictions.

PhD dissertations

Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.

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