811 search results for “immunity infection and tolerance” in the Public website
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Resistance and Revolt in Egypt and Babylonia: The Persian Empire (539-330 BC) in the Eyes of its Rebels
The Persian Empire (539-330 BCE) was the first world empire in history. At its height, it united a territory stretching from present-day India to Libya - and it would take 2,000 years before significantly larger empires emerged in early modern Eurasia. Its size and power was revered by some, feared…
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Facilities and services
There’s more to obtaining a bachelor’s or master’s degree than just studying. For example, where can you go for advice, or to let off some steam, practise your favourite sport, stay in shape, socialise, or simply find some peace and quiet? Leiden University can help in all these areas, and more.
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Diagnosis of tuberculosis infection before immunosuppression
PhD defence
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Disrupted movement makes macrophages more lethal to tuberculosis bacteria
Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…
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Three things the EU must do to survive
“The union’s 60th birthday is not a moment for gifts and cake, but for reinvention around three new strategic idea. (…) The new Europe must protect, improvise and tolerate opposition”. This is what Prof. Luuk van Middelaa, Professor of Foundations and Practice of the European Union and its Institutions,…
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Efficient and flexible platform to isolate and study bacteriophages
We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Immunotherapy to limit atherosclerosis-projects
For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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Minipigs as an Animal Model for Dermal Vaccine Delivery
Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.
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Glen Newey appointed Professor of Pracical Philosophy
From 1 September 2014, Glen Newey takes up the post of Professor of Practical Philosophy in Leiden University’s Institute for Philosophy.
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A much-needed new class of antibiotics
Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Environmental and genetic drivers of wood and lignin formation in flowering plants
In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.
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Novel mediators of anti-tumor immunity
PhD defence
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Human-wildlife Interactions in the Western Terai of Nepal
Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.
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Rethinking Javanese Religion: The Prospect of New Descriptions of Javanese Traditions
This study describes religion in Java.
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New insights for improved pertussis vaccines - Press release -
Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Therapeutic intervention to enhance atherosclerotic plaque stability-projects
For more information regarding ongoing research projects, please contact Dr. Ilze Bot.
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Computational Biology
Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
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An engineering approach to decode immune responses
PhD defence
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Identification of regulators of cancer - immune interactions
PhD defence
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Dissecting the immune microenvironment of breast cancer
PhD defence
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Unwiring beneficial functions and regulatory networks in the plant endosphere
How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?
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Immune Thrombocytopenia: Exploring antibodies, scintigraphy and immune modulation. Moving towards a new era for patients with ITP
PhD defence
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Do common antibiotic treatments influence emotional processing?
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Student projects
Are you looking for a research project?
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Antiviral Pharmacology
The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.
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Individualized prognosis in childhood immune thrombocytopenia
PhD defence
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Innovation in treatment and care
Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…
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Frank Schaftenaar
Science
f.h.schaftenaar@lacdr.leidenuniv.nl | +31 71 527 5134
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Host-Microbe Interactions in Animal Sciences
Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Conflicts between migrants and locals in Leiden and Rotterdam, 1680-1800
Due to its economic prosperity, its policy of (relative) religious tolerance, and its large numbers of migrants, the Dutch Republic has long had a reputation of being the prime example of ‘tolerance’, especially during the seventeenth century. Although the great variety of newcomers in the Dutch Republic…
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Herman Spaink
Science
h.p.spaink@biology.leidenuniv.nl | +31 71 527 5055
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Jip Stam
Faculteit Rechtsgeleerdheid
j.stam@law.leidenuniv.nl | +31 71 527 6360
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Lison Laroche
Science
l.l.s.laroche@cml.leidenuniv.nl | +31 71 527 2727
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Quest for new antibiotics
Gubbens
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Projects
An overview of Quantitative Pharmacology projects
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Prosthetic Joint Infection, new diagnostic and treatment strategies
PhD defence