1,021 search results for “bioactive molecules” in the Public website
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Soft condensed matter
What are the mysteries behind soft condensed matter?
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Freezing conditions in warm disks: snowlines and their effect on the chemical structure of planet-forming disks
This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.
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Adiabatic Energy Loss in Hyperthermal H Atom Collisions with Cu and Au: A Basis for Testing the Importance of Nonadiabatic Energy Loss
Nonadiabatic energy transfer from the translational motion (T) of a molecule impinging on metal surface to the metal’s electrons may determine whether the molecule can lose enough energy to adsorb or react.
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Electroreduction of nitrate and carbon dioxide on copper electrodes: a mechanistic study
In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…
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Surface Temperature and the Dynamics of H2 on Cu(111)
Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…
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Quan/Qual analysis of drugs and metabolites in biological matrices
Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Inextricable ties between chemical complexity and dynamics of embedded protostellar regions
Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Endocannabinoids in health and stress
How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?
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Evolution & Biodiversity
Evolution & Biodiversity is one of the four research themes of the Institute of Biology Leiden.
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Large media attention for Spinoza Prize Michel Orrit
An important award like the Spinoza Prize, the 'Dutch Nobel Prize', generates lots of media attention. An overview.
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Plant Sciences
The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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Gerard van Westen: 'Our model predicts what candidate drugs do in your body'
He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…
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Making fuels from sunlight and CO2
Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.
- Cell Observatory
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Characterization and skin permeation of ketoprofen-loaded vesicular systems
PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.
- Leiden Observatory
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Measurement of the average mass of proteins adsorbed to a nanoparticle by using a suspended microchannel resonator
SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.
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Interstellar Catalysts and the PAH universe
Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.
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Ice and Gas in Protostellar Clouds and Planet-forming Disks
This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.
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Publications
Relevant publications of the CIGR participants.
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Highly Accurate Simulations and Benchmarking of Molecule-Surface Reactions
PhD defence
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Research
Research at the BIOSYN group is comprised of the following research themes:
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New antibiotics
Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.
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Research
Research at the SBC group is comprised of the following research themes:
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Computational Drug Discovery
Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…
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A foldable smartphone? STIBNITE searched for the perfect semiconductor
Roll-up solar panels, bendable phone displays, or better computer chips… The EU project STIBNITE investigated the next generation of semiconductors, made from organic materials based on carbon, nitrogen, and boron. The project has now concluded. During the Open Science Debate on 1 July, the group will…
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Infrastructure
An overview of our infrastructure at the SPP division:
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Biomedical Imaging
The rapid advances in imaging technology enable to see inside the body with ever increasing detail.
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Biophysical Structural Chemistry
Research within our group revolves around the atomic structures of large bio-molecules and their complexes.
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Drug discovery pipeline
The drug discovery pipeline is used to describe the stages in drug discovery. The earliest stage concerns with the identification of potential targets and molecules ('hits') that can modulate their function, while more advanced stages are about developing these hits into viable experimental drugs and…
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Predicting and preventing serious COVID-19 symptoms
Scientists in Leiden are looking for signals in blood samples to predict whether patients will develop serious COVID-19 symptoms or not. Based on that knowledge, they will be able to propose targeted therapies to prevent serious symptoms. They hope to come up with the first results within the week.
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The hunt for frozen organic molecules in space
PhD defence
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Joan van der Waals colloquium
The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.
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Supramolecular and Biomaterials Chemistry
Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…
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Leiden Early Drug Discovery & Development
Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…
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New techniques for tuberculosis treatment
About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
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Research
Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:
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Single gold nanorods in live cells
Visualization of biomolecules in living cells by tagging with gold nanoparticles.
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Degradome analysis of vaccines
The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.