395 search results for “enorme inhibitors” in the Staff website
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Design and Synthesis of Tags, Substrates and Inhibitors for Enzyme Action Studies
PhD defence
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The Design of Transcription Factor-Based Inhibitors to Target Myc – Drop the Myc!
PhD defence
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How bacteria survive with almost no oxygen
Researchers in Leiden have, for the first time, observed how a specialised enzyme helps bacteria stay alinve when oxygen levels are low, and how that process can be blocked. The discovery opens up new possibilities for targeted antibiotics.
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Julia Polsj.p.v.pols@lic.leidenuniv.nl | 071 5272727
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Madouc Bergers made her own enzyme inhibitors for her bachelor’s thesis
For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…
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Jeroen Codeejcodee@chem.leidenuniv.nl | 071 5275037
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Elmer Maurits -
Joel Rüeggerj.ruegger@lic.leidenuniv.nl | 071 5274410
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Hermen Overkleefth.s.overkleeft@lic.leidenuniv.nl | 071 5275037
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start with Open Science: ‘It has increased my workflow efficiency enormously’
Bjørn Peare Bartholdy is Archaeology’s representative in the Open Science Community Leiden (OSCL) . We spoke with him about the value of Open Science and how to make a good start. ‘Open Science is headed to be a regular way of academic work.’ So better to jump on the Open Science bandwagon early on.
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Tom van der Welt.van.der.wel@lic.leidenuniv.nl | 071 5273534
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Substrates and inhibitors to study and modulate ER-I α-glucosidase activity
PhD defence
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Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
PhD defence
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Design of branched swainsonines as selective Golgi alpha-mannosidase inhibitors
PhD defence
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Data Science Research Programme
Universities, companies, organisations and societies are increasingly facing enormous quantities of data. It is a great challenge to transform these Big Data into knowledge, which is why Leiden University has launched a University-wide Data Science Research Programme.
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Cosmic magnifying glass reveals exceptionally heavy dormant black hole in the early universe
Astronomers have measured the mass of a dormant, supermassive black hole in the early universe for the first time. Thanks to a combination of the James Webb Space Telescope and a natural cosmic magnifying glass, researchers were able to weigh the black hole directly based on its gravity.
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Promising new technique to treat cancer receives NWO grant
Biological chemist Nathaniel Martin and his team received an NWO grant to examine how blocking a specific enzyme in our body, NNMT, could be helpful in the treatment of some cancers. Trials with mice have been promising, and together with the Netherlands Cancer Institute, Martin wants to take the next…
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700,000 euros for the fight against aggressive breast cancer
To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…
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Iprotics Wins the Venture Challenge Spring 2022
The winner of the 2022 Spring edition of the NWO Venture Challenge was announced during the Dutch Biotech Event. The innovative startup Iprotics has developed specific proteasome inhibitors that potentially treat multiple myeloma (MM) without the side-effects known from traditional proteasome inhibi…
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‘Cancer treatment should be a six-week life event’
When internist Christian Blank made his very first discovery, his field of immunotherapy was the underdog of cancer research. Now, over 20 years later, Blank has been appointed Professor By Special Appointment of Internal Medicine for his clinical research into immunotherapy and will give his inaugural…
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Unlocking the secrets of DNA repair: Sarah’s curiosity might lead to new cancer treatments
How do cells repair their damaged DNA—and what happens when that process is hindered and cancer arises? Sarah Moser has taken a closer look during her PhD, uncovering surprising insights that could help improve future cancer treatments.
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Three innovative research projects awarded Open Competition Science-M funding
Tracking mucus-eating bacteria, mapping the complexity of planetary nebulae and a signalling pathway in cancer. These three Leiden projects have been awarded Open Competition Science-M funding by the Dutch Research Council.
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Grant for projects that help researchers harness data and technology
Two projects from Leiden University have been awarded a grant through the programme.
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Flu stops when you block the enzyme that cleaves off virus particles
A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.
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From lab discovery to a new drug: the Venture Challenge makes it possible
A breakthrough from the PhD research of medical chemist Elmer Maurits may help patients with autoimmune diseases and blood cancer in the future. But bringing a discovery from the lab to the clinic is not so easily done. Thanks to NWO's Venture Challenge, Maurits and his team will receive ten weeks of…
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Preparing for the next pandemic: scientists discover a new class of influenza antivirals
Researchers from Leiden University, University of York, University of Barcelona/IQTCUB/ICREA and The Francis Crick Institute report a new class of experimental compounds that powerfully block influenza viruses. The findings offer a potential new strategy for treating flu infections and preparing for…
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Nature Communications paper on therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
Cancer immunotherapy represents a significant breakthrough in cancer treatment. However, tumors have numerous mechanisms by which they evade destruction by the immune system. It is therefore necessary to decipher and reverse these mechanisms in order to improve immunotherapies.
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LUMC researchers use viruses to fight prostate cancer
Modified viruses can both kill cancer cells and activate the immune system. This is what an LUMC team discovered while researching a new prostate cancer therapy.
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Funding for four Leiden studies in the fight against arthritis
Four researchers from Leiden University will receive funding from arthritis foundation ReumaNederland over the next five years. This should facilitate long-term research into arthritis.
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Rubicon grant for four Leiden researchers
Four promising young researchers from Leiden University have received a Rubicon grant from the Dutch Research Council (NWO). This grant will enable them to gain valuable research experience at top universities abroad.
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How Europe will be better prepared for the next pandemic
The European PANVIPREP research project started at the Leiden University Medical Center on 11 March. The participants are virologists, biochemists and pharmacists from 14 European countries. Their mission is to develop antiviral drugs to protect Europe during pandemics. At least two such antivirals…
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ERC-grant for Sebastian Pomplun to cure disease by controlling gene expression with synthetic transcription factors
Sebastian Pomplun receives an ERC starting grant of 1.85 million Euros in five years. He wants to develop synthetic transcription factors that can enter cells and activate or deactivate specific genes. For example to disrupt cancer-related processes or to trigger the production of an important missing…
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Rens Tacoma wins Research Prize Italian Studies Working Group
Associate professor Rens Tacoma has won the 2021 Research Prize for Historical Sciences. The prize is awarded annually by the Italy Studies Working Group for the best scholarly publication in the field of Italy Studies in Dutch or Flemish academia.
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Rawi Ramautar new Programme Director of Bio-Pharmaceutical Sciences bachelor’s program
Rawi Ramautar will be the new Programme Director of the bachelor of Bio-Pharmaceutical Sciences starting September 1. The appointment is for four years. Ramautar succeeds Erik Danen, who has held the position since 2019.
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Preserving Syrian excavation data: ‘the documentation here in Leiden is the only thing that’s left’
The Faculty of Archaeology used to be involved in several excavations in Syria, before the outbreak of civil war made travel to the region impossible. One of these excavations is the one of tell Hammam al-Turkman, which started in 1981. Student Ruben Hartman, together with archaeologist Dr Diederik…
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John Boy in NRC on the paradoxes of Generation Z
In this NRC article, sociologist John Boy together with Martijn Lampert and Lonneke van den Berg discuss the three biggest paradoxes of Generation Z: limitless freedom but experiencing enormous stress, being culturally independent but economically dependent and being highly idealistic but also constantly…
- Forgotten heroes
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Second edition of the Nacht van de Digitale Veligheid a success: digital resilience requires collaboration
With a full auditorium at the university's Wijnhaven campus, an extensive programme, inspiring speakers and visitors from a wide range of disciplines, all the ingredients were in place for a successful second edition of the Nacht van de Digitale Veiligheid of Digital Security on 26 May 2026.
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Valerie Pattyn receives Veni funding for research on policy evaluations
Valerie Pattyn has received Veni funding for her project Policy evaluations evaluated. When do they prompt an overhaul of policies? 'I am really looking forward to immerse myself in this study, and I am enormously grateful for this unique opportunity'.
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A university in times of corona: one year on
It is exactly one year ago that the university had to close, bang in the middle of the academic year. Suddenly, on that third Monday in March, we found ourselves at home, working and studying online – many of us from that cramped attic or student room. The momentous coronavirus year in pictures.
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Gilles van Wezel reappointed for four years
Gilles van Wezel has been reappointed as Scientific Director at the Leiden Institute of Biology (IBL). Van Wezel has been director of this institute since September 2018 and will remain so until 1 September 2026.
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Multiple KHMW awards for science students
As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…
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Over a million euros for two studies on solutions to antimicrobial resistance
Two consortia led by Leiden researchers have been awarded over one million euros by the Dutch Research Council and the Ministry of Health, Welfare and Sport to find solutions to antimicrobial resistance.
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Leiden-developed drug candidate ready for final clinical trial phase
Bringing your drug candidates to patients is what many academic chemists dream about, but the road to this goal is long and bumpy. Now, Leiden small molecule nizubaglustat is ready for phase 3 clinical trials. This is thanks to a €132 million funding secured by the biotech spin-out Azafaros.
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From lab to startup: scientist develops new treatment for nerve pain
What do you do when a discovery in the lab shows real promise? Scientist Mirjam Huizenga founded a startup to develop a new treatment for nerve pain caused by chemotherapy. ‘The goal is to give patients a better option.’
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Clichéd version of an autocracy or a restored democracy? The Turkish elections explained
In less than a week’s time, millions of Turkish people are going to decide who will govern their country for the next five years. These elections promise to be the most closely contested in years, with the opinion polls showing very small differences and everything at stake, including for Europe. Alp…
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The Nobel Prize in Chemistry went to an AI model (and rightly so)
Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…
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Happy Holidays from LACDR
Happy Holidays from LACDR
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Ester van der Voet appointed professor of Sustainable Resource Use
The energy transition is already a huge challenge for society, but sustainable use of resources is even more complicated. Yet it is at least as urgent. Ester van der Voet has been working on it for decades, for example within the United Nations. Since February, she is a professor at the Centre for Environmental…
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New professor calls for more research with a ‘global lens’
Jan Aart Scholte is the first professor on the new Leiden interdisciplinary programme, Global Transformations and Governance Challenges. He researches how to tackle global challenges such as climate change and inequality. Inaugural lecture on 4 February.