1,138 search results for “activating lesson design” in the Public website
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Private active cyber defense and (international) cyber security—pushing the line?
This article on private active cyber defense by Dennis Broeders is part of a special issue of the Journal of Cybersecurity, based on a selection of contributions taken from the 2019 Conference on Cyber Norms organized by The Hague Program for Cyber Norms.
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inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Louwerse & Van Vonno, ‘Moving up or down: parliamentary activity and candidate selection’
How do parliamentarians secure their political future? Are their activities in the legislature connected to their place on the candidate list from one election to the next? Political scientists Tom Louwerse and Cynthia van Vonno examine the Dutch case. Their main finding is that speaking in the plenary…
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Using Conjoint Experiments to Study Preferences in Multidimensional Choice Contexts
This case study demonstrates how to design and effectively deploy a (survey embedded) conjoint experiment.
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Ten lessons on making an impact: ‘What dilemmas will you face?’
In the booklet ‘Research with Windows Wide Open’, eight professors in the social sciences and humanities advise colleagues who want to make an impact with their research. They include Leiden professors Andrea Evers and Leo Lucassen. The booklet, published by the Royal Netherlands Academy of Arts and…
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On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases
Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.
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UN celebrity diplomacy in China: activism, symbolism and national ambition online
In this article in International Affairs, Saskia Postema and Jan Melissen examine Chinese celebrities' UN-affiliated Weibo activism in the context of China's increasing engagement in the United Nations, which coincides with a shrinking domestic public sphere under Xi Jinping's leadership.
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metallo-proteins for photocatalytic water splitting: stability and activity in artificial photosynthesis
Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.
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Stress-related prolonged cardiovascular activity: The impact and changeability of stressful cognition without awareness
The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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Transnational Anti-Communism and the Cold War: Agents, Activities, and Networks
How was anti-communism organized in the West? New volume edited by Giles Scott-Smith, Luc van Dongen and Stephanie Roulin on the aims, arguments and associations of a range of transnational anti-communist activists during the Cold War.
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities
Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Blended learning activates students
Recently, the booklet 'Blended Learning, het versterken van het onderwijs op de Universiteit Leiden' has been launched. Sonja Wagenaar, educational adviser at ICLON, was project manager of the three-year Blended Learning Program in which blended learning training was implemented in the studies Psychology,…
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Algorithms help improve building design
Modern optimization algorithms offer solutions for architectural decisions like spatial, structural and energy efficiency. A young computer scientist from Leiden University co-authored a paper that won the Best Paper Award at a leading conference in Krakow during the summer.
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Interactions in Designer Materials Unveiled
Graphene and other layered materials combine into completely new substances. Leiden physicists establish the ground rules for designing such materials by measuring how the layers in the stack interact. Publication on November 29 in Nature Communications.
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Wesseling on The Device Paradigm and Contemporary Practices in Art and Design
On May 18 Janneke Wesseling gave a lecture at the conference
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Professor: Holocaust remembrance has led to very different political lessons
From memorials to the armed forces to memory stones for individual victims. It was only later that the Holocaust took a central role in Western remembrance culture, Cleveringa Professor Frank van Vree notes. ‘Nationalists and human rights activists both invoke the experience of the Holocaust.’
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William Michael Schmidli
Faculty of Humanities
w.m.schmidli@hum.leidenuniv.nl | +31 71 527 2341
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What's Next? Interactive and immersive design
With the What's Next? series we hope to inspire current Media Technology MSc students, show the variety of paths taken after the studies, and bring together alumni. Editions of the series are generally organized around a particular theme by Media Technology MSc students themselves, and followed by social…
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GTGC x Irish Embassy: Small States and Public Diplomacy, Lessons from Ireland’s Security Council Campaign
On 30 January, GTGC hosted a special event together with the Embassy of Ireland. As part of his visit to the Netherlands, John Concannon, Director General of the Global Ireland Unit of the Irish Department of Foreign Affairs, came to the university to engage in a discussion about Ireland's role in international…
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Workshop: Interdisciplinary Research Design for Global Studies
What does it mean to do “global research”? Global studies is an emerging field that focuses on transboundary, international, and global processes and systems, such as climate change, global social media, and globalization. These issues call for researchers to think beyond conventional state actors or…
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Surface Reactivity of Activated CO2 Selective use of energy in splitting CO2
Juurlink
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receptor ligand profiling reveals biased signalling and off-target activity, Nat. Commun., 2017
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…
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A community computational challenge to predict the activity of pairs of compounds
Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)
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Hackers and Designers Summer Academy 2020
Hackers and Designers Summer Academy 2020 will take place remotely from July 20-25
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Multistakeholderism: Prospects of an Institutional Design
On 8 April 2022, Jan Aart Scholte gave a keynote lecture on ‘Multistakeholderism: Prospects of an Institutional Design’ at the T.M.C. Asser Institute.
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comprehensive and predictive theory of catalysis based on simple structure-activity relations
Can we tailor catalysts at the atomic scale by means of high-school chemistry and geometry rules?
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Intersectional activism: Dutch-Turkish Muslim women 'talking back' to securitization and Islamophobia
This article investigates the efforts of influential Turkish Muslim civil society actors to amplify the voices of Muslim women in the Netherlands.
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ESO instrument METIS passes important design milestone
The METIS instrument that’s being built for ESO's future Extremely Large Telescope (ELT) in Northern Chile under the leadership of the Dutch Research School for Astronomy (NOVA) has reached an important milestone: the preliminary design has been approved.
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Smart design carries sound one way
A new computer simulation shows the promising possibilities of the booming field of topology. Smartly designed mechanical structures carry sound exclusively one way and are immune to fabrication errors. Publication on 17 July in Nature Physics.
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Koen van der Blom
Science
k.van.der.blom@liacs.leidenuniv.nl | +31 71 527 4799
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Designing better catalysts using simple chemical concepts
An international team of researchers, including Federico Calle-Vallejo of Leiden University’s Institute of Chemistry, have taken the atomic-scale design of catalysts to the next level. Their research contributes to the quest for a method to generate or store energy more efficiently. The report is published…
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What's Next? Experience-based design
With the What's Next? series we hope to inspire current Media Technology MSc students, show the variety of paths taken after the studies, and bring together alumni. Editions of the series are generally organized around a particular theme by Media Technology MSc students themselves, and followed by social…
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S/N-functionalized NHC ligands: structures, redox properties and electrocatalytic activity
The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.
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The interpretation of physical activity wearable data and its relation with metabolic and brain health in older adults
Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…
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New software for designing sustainable cities
By 2050, more than 70 per cent of the world’s population will live in cities. A group of International researchers has developed software that shows city planners where to invest in nature to improve people’s lives and save billions of dollars.
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A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
PhD defence
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Bartolomeus Häussling Löwgren
Science
b.j.p.m.haussling.lowgren@cml.leidenuniv.nl | +31 71 527 2727
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Peter Berrill
Science
p.berrill@cml.leidenuniv.nl | +31 71 527 2727
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Roozbeh Siyadatzadeh
Science
s.r.siyadatzadeh@liacs.leidenuniv.nl | +31 71 527 4799
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Julian Steinke
Faculteit der Sociale Wetenschappen
j.steinke@fsw.leidenuniv.nl | +31 71 527 2727
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Dirk Visser
Faculteit Rechtsgeleerdheid
d.j.g.visser@law.leidenuniv.nl | +31 71 527 7888
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Lina van Drunen
Faculteit der Sociale Wetenschappen
l.van.drunen@fsw.leidenuniv.nl | +31 71 527 2727
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Joost Batenburg
Science
k.j.batenburg@liacs.leidenuniv.nl | +31 71 527 6985
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining β-Exoglucosidases In Situ and In Vivo
A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…