189 search results for “enorme inhibitors” in the Staff website
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Julia Polsj.p.v.pols@lic.leidenuniv.nl | 071 5272727
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Madouc Bergers made her own enzyme inhibitors for her bachelor’s thesis
For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…
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Jeroen Codeejcodee@chem.leidenuniv.nl | 071 5275037
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Elmer Maurits -
How bacteria survive with almost no oxygen
Researchers in Leiden have, for the first time, observed how a specialised enzyme helps bacteria stay alinve when oxygen levels are low, and how that process can be blocked. The discovery opens up new possibilities for targeted antibiotics.
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Joel Rüeggerj.ruegger@lic.leidenuniv.nl | 071 5274410
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Tom van der Welt.van.der.wel@lic.leidenuniv.nl | 071 5273534
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Hermen Overkleefth.s.overkleeft@lic.leidenuniv.nl | 071 5275037
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Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
PhD defence
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Design and Synthesis of Tags, Substrates and Inhibitors for Enzyme Action Studies
PhD defence
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The Design of Transcription Factor-Based Inhibitors to Target Myc – Drop the Myc!
PhD defence
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Data Science Research Programme
Universities, companies, organisations and societies are increasingly facing enormous quantities of data. It is a great challenge to transform these Big Data into knowledge, which is why Leiden University has launched a University-wide Data Science Research Programme.
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Promising new technique to treat cancer receives NWO grant
Biological chemist Nathaniel Martin and his team received an NWO grant to examine how blocking a specific enzyme in our body, NNMT, could be helpful in the treatment of some cancers. Trials with mice have been promising, and together with the Netherlands Cancer Institute, Martin wants to take the next…
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700,000 euros for the fight against aggressive breast cancer
To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…
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Iprotics Wins the Venture Challenge Spring 2022
The winner of the 2022 Spring edition of the NWO Venture Challenge was announced during the Dutch Biotech Event. The innovative startup Iprotics has developed specific proteasome inhibitors that potentially treat multiple myeloma (MM) without the side-effects known from traditional proteasome inhibi…
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Huge reservoir of star-forming gas discovered in surprisingly mature galaxy in the early Universe
Astronomers have discovered an enormous supply of cold molecular gas in a galaxy shortly after the Big Bang. The finding offers a rare glimpse of the raw material from which the first large galaxies were built. Measurements suggest that around 95 per cent of the normal matter in the galaxy studied,…
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Unlocking the secrets of DNA repair: Sarah’s curiosity might lead to new cancer treatments
How do cells repair their damaged DNA—and what happens when that process is hindered and cancer arises? Sarah Moser has taken a closer look during her PhD, uncovering surprising insights that could help improve future cancer treatments.
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Three innovative research projects awarded Open Competition Science-M funding
Tracking mucus-eating bacteria, mapping the complexity of planetary nebulae and a signalling pathway in cancer. These three Leiden projects have been awarded Open Competition Science-M funding by the Dutch Research Council.
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Flu stops when you block the enzyme that cleaves off virus particles
A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.
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From lab discovery to a new drug: the Venture Challenge makes it possible
A breakthrough from the PhD research of medical chemist Elmer Maurits may help patients with autoimmune diseases and blood cancer in the future. But bringing a discovery from the lab to the clinic is not so easily done. Thanks to NWO's Venture Challenge, Maurits and his team will receive ten weeks of…
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Preparing for the next pandemic: scientists discover a new class of influenza antivirals
Researchers from Leiden University, University of York, University of Barcelona/IQTCUB/ICREA and The Francis Crick Institute report a new class of experimental compounds that powerfully block influenza viruses. The findings offer a potential new strategy for treating flu infections and preparing for…
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Social Sciences Connect
Each month, we publish an article showcasing how social science research and education contribute to solving societal challenges. Researchers, lecturers, students, and societal partners work together to make knowledge accessible and to make a difference. Through open science and engaged education, we…
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James Webb spots the birth of a giant galaxy and a supermassive black hole
Astronomers have used the James Webb Space Telescope to catch an extraordinary glimpse of a massive galaxy taking shape in the early universe. They identified a compact group of at least six galaxies that are likely to merge into a single enormous system. At the heart of this cosmic construction site…
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Rubicon grant for four Leiden researchers
Four promising young researchers from Leiden University have received a Rubicon grant from the Dutch Research Council (NWO). This grant will enable them to gain valuable research experience at top universities abroad.
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Rawi Ramautar new Programme Director of Bio-Pharmaceutical Sciences bachelor’s program
Rawi Ramautar will be the new Programme Director of the bachelor of Bio-Pharmaceutical Sciences starting September 1. The appointment is for four years. Ramautar succeeds Erik Danen, who has held the position since 2019.
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Cosmic magnifying glass reveals exceptionally heavy dormant black hole in the early universe
Astronomers have measured the mass of a dormant, supermassive black hole in the early universe for the first time. Thanks to a combination of the James Webb Space Telescope and a natural cosmic magnifying glass, researchers were able to weigh the black hole directly based on its gravity.
- Forgotten heroes
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Funding for green fertilisers, high-energy particles and a circular power plant
Researchers at the Faculty of Science work at the frontiers of knowledge every day, tackling today’s major societal challenges. Their work is recognised through grants, prizes and other awards. We highlight some of these achievements below.
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Gilles van Wezel reappointed for four years
Gilles van Wezel has been reappointed as Scientific Director at the Leiden Institute of Biology (IBL). Van Wezel has been director of this institute since September 2018 and will remain so until 1 September 2026.
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Multiple KHMW awards for science students
As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…
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Over a million euros for two studies on solutions to antimicrobial resistance
Two consortia led by Leiden researchers have been awarded over one million euros by the Dutch Research Council and the Ministry of Health, Welfare and Sport to find solutions to antimicrobial resistance.
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Leiden-developed drug candidate ready for final clinical trial phase
Bringing your drug candidates to patients is what many academic chemists dream about, but the road to this goal is long and bumpy. Now, Leiden small molecule nizubaglustat is ready for phase 3 clinical trials. This is thanks to a €132 million funding secured by the biotech spin-out Azafaros.
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From lab to startup: scientist develops new treatment for nerve pain
What do you do when a discovery in the lab shows real promise? Scientist Mirjam Huizenga founded a startup to develop a new treatment for nerve pain caused by chemotherapy. ‘The goal is to give patients a better option.’
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The Nobel Prize in Chemistry went to an AI model (and rightly so)
Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…
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Ester van der Voet appointed professor of Sustainable Resource Use
The energy transition is already a huge challenge for society, but sustainable use of resources is even more complicated. Yet it is at least as urgent. Ester van der Voet has been working on it for decades, for example within the United Nations. Since February, she is a professor at the Centre for Environmental…
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‘Una Europa is like a sweet shop for our researchers’
A European bachelor’s degree, an enormous web of collaborations and masses of fantastic opportunities for researchers and support professionals: in two years, we as a university have come far within the Una Europa alliance, says Professor Joanne van der Leun. She rejoined the Una Europa Board of Directors…
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Marcello Bonsangue new Scientific Director of the LIACS institute
Marcello Bonsangue will be the new Scientific Director of the Leiden Institute of Advanced Computer Science (LIACS) from January 2024. Bonsangue has been appointed for four years. He succeeds Aske Plaat, who led the institute for eight years.
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Olympic gold for Industrial Ecology student Dirk Uittenbogaard
Dirk Uittenbogaard, a student on the Delft-Leiden Master’s in Industrial Ecology, has won a gold medal for rowing at the Olympic Games in Tokyo. Uittenbogaard took gold in the men’s quadruple sculls, together with Abe Wiersma, Tone Wieten and Koen Metsemakers.
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Ans
Ans is Leiden University's digital testing platform. It allows you to make digital exams using a variety of questions for summative and formative assessment.
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How the eating habits of a limited group of Americans determine sustainability
Masses of hamburgers, steaks, cheese and a lot of eggs: Americans love their animal products. But researcher Oliver Taherzadeh discovered that only a relatively small group of high-volume consumers need to modify their diet to achieve an enormous environmental gain.
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Marjo de Graauw looks after the wellbeing of student and teacher
Heavy! This is the first word that comes to lecturer Marjo de Graauw’s mind when she looks back on the past year. But with her creativity and experience with educational innovation she was nonetheless able to provide her usual high standard of teaching.
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Miranda van Eck new Scientific Director of the LACDR institute
As of 1 September Miranda van Eck will be the new Scientific Director of the Leiden Academic Centre for Drug Research. She succeeds Hubertus Irth, who led the institute since 2016. Van Eck has been appointed for a period of four years.
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Students kick-off next construction phase of new Gorlaeus building
And the construction has started! Students of the Leiden Science study associations ceremoniously hammered down the first poles of the new Gorlaeus on Tuesday morning. By doing so, they initiated the second phase of the construction of the second part of the new building.
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‘The Senior Teaching Qualification allows you to reflect on your teaching and interact with other lecturers’
Fifteen passionate lecturers from Leiden University were awarded the Senior Teaching Qualification (SKO) on Thursday 27 January. One of them is Frank Takes, as of 1 February Associate Professor of Computer Science. For him the SKO was a good opportunity to reflect on how he teaches.
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How to choose the optimal location for wind turbines in the North Sea
In the next decades, thousands of wind turbines will be added to the North Sea. Environmental scientist Chen Li identified the most beneficial areas for their construction, focusing on material use, carbon footprint, and environmental impact. His paper was published in Environmental Science & Techno…
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Building a strong research support network
‘We can only achieve this if we work together.’ This is what Rector Magnificus Hester Bijl emphasised as she spoke about professional research support at the opening of the second Research Support Conference at PLNT on 14 June. For the 80 research support staff present, learning and inspiration was…
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Faculty of Science kicks off the Academic Year with a vibrant talk show
The Faculty of Science launched the new Academic Year on 21 September with a special We Are Science talk show. Dean Paul Wouters starred in his role as talk show host and received a wide variety of guests.
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Ewine van Dishoeck goes stargazing
From the birth of the universe to the molecules in a planet's atmosphere. The first five pictures from the James Webb Space Telescope (JWST) show the enormous range in which the space telescope can operate. Ewine van Dishoeck, professor of molecular astrophysics, took a look at the first images Tuesday…
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Big reduction in CO2 footprint in 2020 due to coronacrisis
The university's CO2 footprint - a visual representation of Leiden University's environmental impact - is calculated every year. The CO2 footprint for 2020 shows a striking break in the trend in terms of energy use, mobility and waste.
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Jasper's day
Jasper Knoester is the dean of the Faculty of Science. How is he doing, what exactly does he do and what does his day look like? In each newsletter, Jasper gives an insight into his life.