2,049 search results for “chemical industry” in the Public website
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Publications
Recent publications
- Laboratory for Ceramics Studies
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Using zebrafish to target the Achilles’ heel of cancer
Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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NWO-grant for degration of biomass
Dr. Erik Vijgenboom (IBL) and Dr. Peter Punt (IBL/TNO) obtained a new NWO-grant for their project FILAZYME to develop filamentous micro-organisms for enzyme production to degrade biomass.
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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LED3 Chemical Biology Talk: Towards the development of orally available peptide therapeutics
Lecture
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Research
Research at the SBC group is comprised of the following research themes:
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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New antibiotics
Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.
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Gas-surface reaction dynamics and surface science
The local ordering of atoms at the surface of a metallic particle determines its catalytic activity and selectivity. As energy systems of the future will be based on efficient catalytic conversion of small molecules in closed cycles, we study how structural effects of catalysts can be used to our ad…
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Selective and efficient electrochemical CO2 reduction on nanostructured catalysts
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Unravelling the chlorine production reaction
How can we make the production of chlorine cheaper and more friendly for the environment?
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Scheurrak SO1 in the Maritime-Cultural Landscape
This project combines and reconsiders all the available evidence of the Scheurrak SO1, and use new archival databases and modern archaeological techniques to shed new light on the material culture of the Baltic grain trade and the Holland shipbuilding industry at the turn of the sixteenth century.
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Linking soil microbial community dynamics to N2O emission after bioenergy residue amendments
Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.
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Creating Global Scenarios of Environmental Impacts with Structural Economic Models
To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.
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Multi-objective Evolutionary Algorithms for Optimal Scheduling
Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…
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Anticancer compounds from actinomycetes
How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?
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Case studies
The research that is united in the Liveable Planet programme, touches upon a wide range of aspects of human life. The goal is to deepen and expand the scope and to connect more researchers. The following case studies are examples of current research projects.
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Making Sense of Illustrated Handwritten Archives
Many handwritten and illustrated archives contain a wealth of information, but are largely underexplored because they are complex and difficult for computers to decipher. The aim of this project is to develop a digital environment that resolves this challenge and connects heterogeneous archival content…
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HazMat transportation safety assessment: Analysis of a “Viareggio-like” incident in the Netherlands
Relevant safety issues are associated with hazardous materials transportation, especially when transport routes cross populated areas. This article for the Journal of Loss Prevention in the Process of Industries analyses a 2015 accident with a freight train in Tilburg, comparing it to the Viareggio…
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Erica G. Wilson
PhD at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands
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The town, its waste and the cesspit
The rise and fall of the cesspit in an urban context
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Career prospects
With a master’s degree in Astronomy you are well prepared for jobs in research, industry and the public sector, including technological, financial and consultancy companies, research institutes, governments and science communication organizations.
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Applied Mathematics (MSc)
The master's specialisation Applied Mathematics at Leiden University focuses on both computational and fundamental aspects of analysis and probability. It’s also an ideal basis for a PhD degree. Applied Mathematics is an excellent choice if you have the aspiration to pursue a PhD degree
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Career prospects
With a master’s degree in Astronomy you are well prepared for jobs in research, industry and the public sector, including technological, financial and consultancy companies, research institutes, governments and science communication organizations.
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Contact
Do you have any questions about the Industrial Ecology master’s programme? Please contact us! It is also possible to schedule a Skype-Call with our study advisors or one of our students. Moreover, we have online Walk-In hours every third Friday of the month.
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Career prospects
Graduates of the master's specialisation in Global Ethnography are proficient in analysing and reporting global vulnerabilities and local forms of resilience.
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Career prospects
Many students receive their first job offer during or right after their Business Studies internship. After graduating you can also aim for a career in Bio-Pharmaceutical research.
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LHSC booster grants
The LHSC booster grants awarded are described below. The summaries below are aimed at the general public. For further detail, please contact the researchers in question.
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Vaccine delivery
Vaccination via the skin or the mucosae
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Collaborations
Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).
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Molecular mechanisms of adverse outcome and translational biomarkers
Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…
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Human skin equivalents: understanding the lipid biosynthesis in the skin
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.
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Improvisations in phototrophy
Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Water related adsorbates on stepped platinum surfaces
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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Zipping into Fusion
Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros
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The puzzle of protoplanetary disk masses
My work focuses on a class of astronomical objects called protoplanetary disks.
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Protostellar jets and planet-forming disks: Witnessing the formation of Solar System analogues with interferometry
The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.
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Rationally designed peptide based functional biomaterials
Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Photocatalytic redox reactions at the surface of liposomes
Promotor: E. Bouwman, Co-promotor: S. Bonnet