1,285 search results for “high throughput screening and microscopy” in the Public website
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Single-molecule microscopy in zebrafish embryos
PhD defence
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Core Facilities
Core Facilities are shared resources that provide access to instruments, technologies and services to researchers across the Institute of Biology. They are staffed by scientists with vast experience in their field, ensuring that all researchers can count not only on the latest available technology…
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Huub de Groot
Science
groot_h@chem.leidenuniv.nl | +31 71 527 4539
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Research
Research at the BIOSYN group is comprised of the following research themes:
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Personalized Medicine
Getting personal
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Strikes the result of high inflation
Employees are laying down their work in various sectors, such as regional public transportation and Dutch postal service PostNL. Inflation appears to be increasing dissatisfaction about working conditions, thinks Barend Barentsen, Professor in Labour Law at Leiden University. ‘It's the final straw.’
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Aspects of cosmic acceleration
The focus of the dissertation
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Resolution of electron microscope greatly improved
The use of a new type of detector has generated a strong improvement in the resolution of electron microscopes. The 'low-energy electron microscope' (LEEM) can now be used for research on the thinnest possible materials. The tests with the detector represent the first result of the ESCHER project.
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Paradox in superconductivity at high temperature
Nature publishes an article on a paradoxical discovery in superconductivity. Physicists are searching for superconductivity at high temperatures so that less cooling is needed in for example MRI machines. News & Views article by Prof. Jan Zaanen in the same issue of August 19th.
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Glucocorticoids in zebrafish
A novel in vivo model system for studies on glucocorticoid resistance
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Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
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Surface and Interface Science
The nanoscale structure of a catalyst under reaction conditions determines its activity, selectivity, and stability. For the production of sustainable energy and materials, new catalysts are needed. By understanding the structure-activity relationships of catalysts under reaction conditions, insight…
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Quantum Matter and Optics
Research groups in the Quantum Matter & Optics programme investigate electronic properties of matter and light-matter interactions with emphasis on quantum information.
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Growth and development of actinomycetes
We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.
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Optoplasmonic detection of single particles and molecules in motion
Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.
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A physicochemical study of Medieval and Post-Medieval ceramics from the Aegean
Archaeometric analysis of glazed pottery assemblages from the Early Byzantine to the Early Modern periods in the Aegean.
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Insights into microtubule catastrophes: the effect of end-binding proteins and force
For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.
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1st Leiden Centre for Interdisciplinary Genome Research meeting
The 1st CIGR meeting was held on March 30, 2021, with talks by representatives of all participating groups.
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Sense Jan van der Molen Lab - Physics of Quantum Materials
In our lab, we investigate the physics and material properties of low-dimensional systems.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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HEPGAME
HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Physicist Michel Orrit new member KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit.
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Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein
Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)
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Barend Mons appointed Chair of European Commission’s High Level Expert Group
Professor Barend Mons has been appointed Chair of the Commission High Level Expert Group
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
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Colorectal cancer screening for average- and high-risk individuals Beyond one-size-fits-all
PhD defence
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Insights from scanning tunneling microscopy experiments into correlated electron systems
PhD defence
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Leiden Physics hosts 2016 NEVAC day
The Leiden Institute of Physics hosted the annual conference of the Dutch Vacuum Society (NEVAC). Experts in the field of vacuum experiments talked about their research. The 2016 NEVAC Prize was awarded to PhD student Martijn Vos from the TU Eindhoven.
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Hooray! This extremely sensitive microscope survived its relocation
Moving an electron microscope of 2000 kg is a delicate challenge. The highly sensitive instrument needed to be moved to a new measurement hall, but even a tiny bump could damage it. After a few nerve-racking weeks of preparing the move and reinstalment, the researchers finally have a verdict: the instrument…
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Evolution of bacterial movement revealed
An international team with researchers from Leiden revealed how a bacterium repurposed an internal system to control its movements. Movement control is very important in host invasion, which can lead to disease. Publication on 27 April in Nature Communications.
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Slovenian and Czech high school students visit Leiden University
Sixty-four high school students from Slovenia, Czech Republic and The Netherlands have visited Leiden University in the week of 7-11 November, as part of the Talent Education Project. They split in eight groups, of which some went to the science faculty to conduct research projects.
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Thomas Hankemeier
Science
hankemeier@lacdr.leidenuniv.nl | +31 71 527 4226
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Michel Orrit and Hermen Overkleeft members KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit and chemist Hermen Overkleeft.
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Quantum Matter and Optics
The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.
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Setup: MRFM
MRFM combines the principles of magnetic resonance and atomic force microscopy.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Microbial communities in Pampa soils; impact of land use changes, soil type and climatic conditions
Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae
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Enabling Analytical Technology
Within the MAC our Enabling Analytical Technology team is working to innovate all steps of analytical workflows. This includes developing novel sample preparation modules, creative sample handling methods, automated workflows, and more. Several projects implement the microfluidic principle of segmented…
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Orchestration of Distributed LOFAR Workflows
The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.
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Quan/Qual analysis of drugs and metabolites in biological matrices
Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?
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Data Driven Modeling & Optimization of Industrial Processes
Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.