The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Het proefschrift omschrijft de chemische synthese van fenolische glycolipiden van verschillende mycobacteriën met het doel om deze te kunnen gebruiken voor immunologisch onderzoek.

The Public Policy and Innovation department of the Institute of Public Administration focuses on shaping, implementing, and evaluating policy through innovative approaches. Our goal is to tackle complex societal challenges by exploring technological advancements and creative policy tools.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Conference

Arts and culture, Pianoconcert

Thanks to its early civilisation and continuous mix of influences, the Muslim world has a rich and varied culture. The study of material culture, books, stories, films and increasingly television series teaches us about the structure of modern-day Muslim societies.

By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Former Leiden Observatory PhD candidate Danna Qasim has won no less than two prestigious prizes with her thesis, titled 'Dark ice chemistry in interstellar clouds'. Qasim received the IAU PhD Prize from the IAU. The Astrochemistry Subdivision of the American Chemical Society (ACS) honoured her work…

This subproject of 'From Homo Economicus to Political Animal' analyzes Greek economic thinking in late 5th- and 4th-century philosophical circles.

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

Debate, Lunch discussion

The programme consists of 60 EC, to be completed in one year.

On 16 December 2019, Jan-Harm de Villiers defended his thesis 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. The doctoral research was supervised by Prof. P. Cliteur.

Contact Supramolecular & Biomaterials Chemistry

hotocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Contact Theoretical Chemistry

Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

Leiden researchers Arko Ghosh and Enea Ceolini analysed the usage data of hundreds of mobile phones and discovered that our body has rhythms ranging between 7 and 52 days. These cycles influence how we behave. Their research resulted in an article in npj Digital Medicine journal, a Nature Portfolio…

Huiselijk geweld is een ingrijpend probleem in Nederland, met jaarlijkse fatale gevolgen. De impact gaat verder dan alleen de slachtoffers zelf en raakt ook nabestaanden en de samenleving als geheel. Tot nu toe/Momenteel ontbreekt het echter aan een gestructureerde manier om fatale gevallen systematisch…

Drawing on the analogical lessons of the Great War, this article uses applied history to analyze how the four parallels discerned can help us make sense of contemporary Sino-American rivalry

This article describes the phenomenon of firearms violence and the importance of including non-lethal firearms violence in understanding this phenomenon.

This omnibus brings together some old and some recent works by Jos Gommans on the warhorse and its impact on medieval and early modern state-formation in South Asia.

Since its beginnings, Leiden University has been home to scholars with a broad and diverse expertise in the histories, languages, literatures and material cultures relevant to the study of Jews and Judaism from antiquity to modern times.

Cultural biographies of persons, objects and 'natural' places in the Bronze Age of the Southern Netherlands, c. 2300-600 BC.

In this project, we use social network analysis to analyze the behavior of users in online forums and associated marketplaces over time.

Firearms and violence in Europe–A systematic review by Katharina Krüsselmann, Pauline Aarten, Marieke Liem

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Why is there no Northeast Asian security architecture? Assessing the strategic impediments to a stable East Asia. In this article, published in 'The Pacific Review', the authors Wang (Peking University) en Stevens (Leiden University) discuss the reasons why.

A number of scholars joint forces to analyse and re-analyse a number of Merovingian cemeteries and publish the results in the series Merovingian Archaeology in the Low Countries published by Habelt Verlag in Bonn (Germany). We call it the ANASTASIS project. This is the third volume in which the data…