In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: B. van de Water

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Promotor: B. van de Water

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Source: J Cheminform, Volume 7, Issue 1 (2015)

Supervisor: Indira Nederpelt

Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

Following the format of Privacy Law Scholars Conference (PLSC) in the United States, PLSC Europe is a conference for stimulating work in progress. Discussants, rather than authors, kick off and lead a conversation on a paper. There are no panels or presentations by the authors. Attendees read papers…

The Faculty of Science is located at the Leiden Bio Science Park. It was founded more than two centuries ago and currently, more than 8000 people are working and studying at the eight institutes.

Meet Bart, Reza, Weiyan, James, Daphne and Yasmin.

What was the relationship between women and modern media in different parts of Asia in the 20th century? Under what historical and social conditions did women achieve prominence in popular music in Asia?

Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.

Dovilė Rimkutė, Assistant Professor at the Institute of Public Administration in The Hague, received the prestigious VENI grant for her research on risk regulation. 'We expect science to be the core basis of risk regulators’ decisions,' says Rimkutė, 'but at times threats to the regulators’ reputation…

Can process-oriented dynamic testing be applied to everyday educational practice?

This study focuses on increasing our understanding of the different pathways converts take during conversion to Islam.

The LUCL Labs consist of four spaces equipped to conduct high-quality experimental linguistic research.

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

Ethnography and Photography in a Moroccan Berber Village

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

With Leiden University Press, LUCIS publishes a peer-reviewed book series “Debates on Islam and Society” aimed at a broad audience. A number of books in this series are available in open access.

What is the effect of a dynamic training in children’s inductive reasoning skills and how is it related to children’s school performances and language development.

What is the optimal way to utilise intermediate assessment in improving study behaviour and study success?

How did digital intermediality symbolise and facilitate the transfer of content from popular culture into policy statements and vice versa in the period between 1945 and the new millenium?

Research goal: To support the design of technologies (counter-measures and communication measures) for the prevention, interdiction and mitigation of lone actor extremist events (LOEEs), which are hard to anticipate, yet can be highly damaging to local and national communities and therefore must be…

In the Surveillance and Security Threat Monitor 2022-2023, the research project thematically examined threat developments.

During the 1980s and early 2000s, authors like Alex Schmid and Andrew Silke demonstrated the paucity of first-hand insights being used to study terrorism and the consequences this had for the reliability of the findings beings presented. But to what extent have these issues endured?

Now and then we organise book launches to present the latest publications, both academic and popular, in our broad field.

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Psycholinguistic research

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

In October 2014 a new publication on artistic research has been launched. The book is called Artistic Experimentation in Music. An Anthology, edited by Darla Crispin and Bob Gilmore, and published by Leuven University Press.

GoodBrother aims to increase the awareness of the ethical, legal, and privacy issues associated with audio- and video-based monitoring and to propose privacy-aware working solutions for assisted living.

The Netherlands generally performs above average in the protection of personal data, according to research carried out at Leiden University. Germany is the leading country, while countries such as Italy and Romania are lagging behind.

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

Cyber agent technology and intelligence agencies is a project that is commissioned by Tracks Inspector, a Dutch company that develops innovative software.

A warm welcome to the Graduate School of Social and Behavioural Sciences at Leiden University.