1,578 search results for “bart cancer” in the Public website
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Kim Elbertsek.elbertse@lacdr.leidenuniv.nl | 071 5272727
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Elsa Neuberte.neubert@lacdr.leidenuniv.nl | 071 5272727
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Jeroen Jansenj.c.jansen@lumc.nl | 071 5269111
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Andraniek Evadgian -
Alfred Vertegaala.c.o.vertegaal@lumc.nl | 071 5269111
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Luca Giomi Group - Soft and Bio Mechanics
We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.
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High school programmes
The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Thomas Schmidt Lab - Single Molecule Microscopy
Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Centre for Microbial Cell Biology
The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.
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Activity-Based Proteasome Profiling
Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea
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Overview
The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
Source: J Cheminform, Volume 7, Issue 1 (2015)
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Introduction
Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Synthetic Affinity-Based Probes for ADP-Ribose Interactome Studies
Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.
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PLSC-Europe
Following the format of Privacy Law Scholars Conference (PLSC) in the United States, PLSC Europe is a conference for stimulating work in progress. Discussants, rather than authors, kick off and lead a conversation on a paper. There are no panels or presentations by the authors. Attendees read papers…
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About Faculty of Science
The Faculty of Science is located at the Leiden Bio Science Park. It was founded more than two centuries ago and currently, more than 8000 people are working and studying at the eight institutes.
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Team profiles Project 0100
Meet Bart, Reza, Weiyan, James, Daphne and Yasmin.
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Voices of Asian Modernities: Women, Gender, and Sexuality in Asian Popular Music of the 20th Century
What was the relationship between women and modern media in different parts of Asia in the 20th century? Under what historical and social conditions did women achieve prominence in popular music in Asia?
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Niko Tinbergen lecture 2019: Stem cells, mini organs and eternal life
Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.
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VENI grant for Dovilė Rimkutė: Reputation is key for risk regulation
Dovilė Rimkutė, Assistant Professor at the Institute of Public Administration in The Hague, received the prestigious VENI grant for her research on risk regulation. 'We expect science to be the core basis of risk regulators’ decisions,' says Rimkutė, 'but at times threats to the regulators’ reputation…
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Investigating the possibilities and limitations of Process-oriented Dynamic Testing.
Can process-oriented dynamic testing be applied to everyday educational practice?
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Understanding Dutch converts to Islam: On turbulent trajectories and (non-) involvement in jihadist movements
This study focuses on increasing our understanding of the different pathways converts take during conversion to Islam.
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Lab facilities
The LUCL Labs consist of four spaces equipped to conduct high-quality experimental linguistic research.
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Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein
Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)
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Nostalgia for the Present
Ethnography and Photography in a Moroccan Berber Village
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RE-PAIR: Unravelling the Impact of Emotional Maltreatment on the Developing Brain
What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?
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Debates on Islam and Society (LUP)
With Leiden University Press, LUCIS publishes a peer-reviewed book series “Debates on Islam and Society” aimed at a broad audience. A number of books in this series are available in open access.
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Dynamic Testing and the Relation with School performance and Language difficulties.
What is the effect of a dynamic training in children’s inductive reasoning skills and how is it related to children’s school performances and language development.
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Effects of intermediate assessments on study behaviour, time on task and achievement
What is the optimal way to utilise intermediate assessment in improving study behaviour and study success?
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The Future is Elsewhere: Towards a Comparative History of the Futurities of the Digital (R)evolution
How did digital intermediality symbolise and facilitate the transfer of content from popular culture into policy statements and vice versa in the period between 1945 and the new millenium?
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PRIME – Predicting, Interdicting and Mitigating Extremism
Research goal: To support the design of technologies (counter-measures and communication measures) for the prevention, interdiction and mitigation of lone actor extremist events (LOEEs), which are hard to anticipate, yet can be highly damaging to local and national communities and therefore must be…
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Dreigingsmonitor bewaken en beveiligen 2022-2023
In the Surveillance and Security Threat Monitor 2022-2023, the research project thematically examined threat developments.
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The state of research on terrorism
During the 1980s and early 2000s, authors like Alex Schmid and Andrew Silke demonstrated the paucity of first-hand insights being used to study terrorism and the consequences this had for the reliability of the findings beings presented. But to what extent have these issues endured?
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Book presentations
Now and then we organise book launches to present the latest publications, both academic and popular, in our broad field.
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Sodium ion binding pocket mutations and adenosine A2A receptor function
Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)
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Babylab
Psycholinguistic research
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Exposed to events that never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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Artistic Experimentation in Music – An Anthology
In October 2014 a new publication on artistic research has been launched. The book is called Artistic Experimentation in Music. An Anthology, edited by Darla Crispin and Bob Gilmore, and published by Leuven University Press.
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CA19121 GoodBrother
GoodBrother aims to increase the awareness of the ethical, legal, and privacy issues associated with audio- and video-based monitoring and to propose privacy-aware working solutions for assisted living.
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De bescherming van persoonsgegevens, Acht Europese landen vergeleken
The Netherlands generally performs above average in the protection of personal data, according to research carried out at Leiden University. Germany is the leading country, while countries such as Italy and Romania are lagging behind.
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Dynamic Testing and Excellence
If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?
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Cyber agent technology and intelligence agencies
Cyber agent technology and intelligence agencies is a project that is commissioned by Tracks Inspector, a Dutch company that develops innovative software.
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Graduate School of Social and Behavioural Sciences
A warm welcome to the Graduate School of Social and Behavioural Sciences at Leiden University.