Are you interested in combining your Science master programme with the Education specialisation? Learn more and watch the introduction video.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

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Peptides are routinely synthesized in the range of 5-80 amino acids, in an amount of 1-200 µmol (smaller and larger amounts are also possible).

From development of nanomaterials to advanced instrumentation and smart software systems, this specialisation empowers students to become a key player in tomorrow’s technological breakthroughs—through interdisciplinary research, industrial collaboration, and innovation-driven learning.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Are you interested in combining your master programme with the Science Communication and Society specialisation? Learn more and watch the introduction video.

Chemistry is all around us: from nutrition and smartphones to medicine. The field is developing rapidly, as the world population continues to grow and resources become scarce. MST will educate you on the basics of working towards a clean and healthy world.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

In the night of 2 July chemist Hermen Overkleeft was interviewed on the

Where exactly on the surface of a catalyst do the chemical reactions occur? Until now, it has always been a challenge to identify the exact locations of these ‘active sites’. In a new article in Nature, Leiden chemists helped their international colleagues reveal new insights into this issue. Their…

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

How do lipases in Mycobacterium tuberculosis help the bacteria survive, and can we target them to create new antibiotics?

The LACDR represents the core of bio-pharmaceutical research at Leiden University, and we interact closely with our partners:

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Promotor: H.J.M. de Groot

Leiden University offers its students a wide range of bachelor's, master's and minors that explore sustainability or climate. Here, you find an overview of those programmes in the academic year 2020-2021.

The BPS and Education master specialisation gives you the opportunity to combine fundamental chemistry research with an excellent education in becoming a Chemistry teacher.

Located in the friendly small city of Leiden in the centre of the Netherlands, Leiden University has for centuries been at the forefront of developments in science and that excellent continues today, with world-leading institutes of computer science, mathematics, physics, astronomy, and chemistry. …

Get to know us through our online and in-person events for prospective students!

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

Of the 113 Spinoza Prizes that have been awarded since 1995, 29 have gone to researchers from Leiden University.

Climate change and energy transition were an important theme of the Dutch provincial elections: how should we invest in new sources of energy? Leiden University conducts multidisciplinary research into renewable energy solutions. Read more about this in the ‘Renewable Energy’ research dossier.

Our mission is to improve the description, prediction, understanding and the prevention and treatment of mood disorders, including unipolar and bipolar depression, as well as suicidal thoughts, feelings, and behaviors. To tackle this ambitious mission, we focus on several research streams.

Systematic investigations into religious precepts, worldly rules of law and legal practices in the Muslim world show clearly how these societies deal with justice and injustice. Sharia, the Islamic ‘legal system’, plays an important role in this context.

Information about the association and the board.

The drug discovery pipeline is used to describe the stages in drug discovery. The earliest stage concerns with the identification of potential targets and molecules ('hits') that can modulate their function, while more advanced stages are about developing these hits into viable experimental drugs and…

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Student project opportunities at the MolPhys group

Dr at CAMAG Laboratory, Switzerland

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This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

This thesis focuses on the study of transient and variable radio sources in the universe.

Research in the natural computing group covers theoretical foundations, the development of new algorithms, and interdisciplinary applications of natural computing methods.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Are you interested in combining your Science master programme with the Business Studies specialisation? Learn more and watch the introduction video.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

The electrochemical hydrogenation reaction is an alternative approach for the transformation of unsaturated bonds without the use of flammable dihydrogen gas.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

The E2CB programme has been launched to bring CO2 emissions to zero by 2050. The goal: to produce all raw materials for the chemical industry from sustainable sources. Professor of Electrochemistry Marc Koper is involved in the project.