Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Anjali Pandit, René Olsthoorn, Alia Matysik, Sebastian Geibel and Steffen Brünle.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

After graduation you have a lot of opportunities: academics are highly sought after in Dutch secondary education or mbo teaching. You can also aim for a management position or work as a researcher within the field of Computer Sciences.

This specialisation combines advanced training in physics at a world-class institute with interdisciplinary courses on high-tech instrumentation and design and an industrial placement, preparing you for a career in which you develop and apply sophisticated physics techniques to innovations in indust…

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

In this thesis, we present new laboratory data of interstellar dust analogues.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Promotor: Prof.dr. A.G.G.M. Tielens, Co-Promotor: J.B.R. Oonk

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

The specialisation Science Communication and Society (SCS) concerns science communication in a broad sense. The program focuses on the link between science and society and covers knowledge and skills in the field of science communication.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Planets are formed in disks of gas and dust around young stars.

Conference

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

The specialisation High-Tech Innovation is for MSc students in Sciences who are interested in interdisciplinary technologies and research related to /important for high technology industries, e.g. the semi-conductor industry or nano-fabrication. In addition to their primary field of study, students…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…

The ability to collect and interpret huge quantities of data has become indispensable to society and academia. Leiden University is a knowledge and expertise centre for data science that places the emphasis on interdisciplinary collaboration and innovation.

In 2023, many of our students and staff won great prizes and secured important research grants.

Lecture

The Leiden Leadership Programme (LLP) employs experts in the field of leadership. They equip LLP students with the necessary leadership knowledge, insights and skills to increase their social impact.

How can legal education in Indonesia become more relevant for supporting the rule of law and providing legal services that common citizens need?

JUSTREMIT is an ERC-funded project that brings together political theory, ethnography, and security studies in an interdisciplinary study of remittances and global justice.

The sustainable business law research group is dedicated to researching the complex relationship between business activities and sustainability. It strives to develop legal solutions that contribute to a more ethical, just, ecologically responsible and socially inclusive society. Our aim is to develop…

The making of sacrifices seems part and parcel of any elite sportsperson’s life. Remarkably, the insights that we find in the current literature in social sport studies are not able to make sense of the references to sacrifice in the data that emerged in the context of this study on the social significance…

Expand your knowledge, gain international experience, and explore global challenges. From summer schools and online courses to virtual exchanges, Leiden University students at all levels (bachelor’s and master’s students, and PhD candidates) can participate in a range of learning opportunities.

The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…

Are you curious about how societies are governed - and what makes a society just? At Leiden University, you’ll explore democracy, law, safety and public policy in both national and international contexts. From human rights to climate legislation, from elections to ethical dilemmas: you’ll learn to analyse…

Highlights the extent to which the two thinkers share a common philosophical framework, while also demonstrating how Levinas shifts the orientation of philosophical thinking from truth to justice.

LCCP is envisaged as an open space for stimulating discussion, critical debate and inventive co-operation in the Dutch philosophical community. It does not pursue a specific agenda but welcomes different readings of our shared philosophical situation, because it believes that deeper understanding is…