We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

During the Leiden Science Family Day, you will visit places that are normally closed to the public: go backstage at the Faculty of Science!

The CIGR comprises research groups from the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

Why is Crossnational and Cross-cultural agents such as Henrich Carloff and Willem Leyel important when studying Early Modern expansion?

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

A new computer simulation shows the promising possibilities of the booming field of topology. Smartly designed mechanical structures carry sound exclusively one way and are immune to fabrication errors. Publication on 17 July in Nature Physics.

To be eligible for Physics at Leiden University, you must meet the following admission requirements.

To be eligible for Physics and Education at Leiden University, you must meet the following admission requirements.

To be eligible for Physics and Business Studies at Leiden University, you must meet the following admission requirements.

To be eligible for Research in Physics, Biological and Soft Matter Physics at Leiden University, you must meet the following admission requirements.

To be eligible for Research in Physics, Cosmology at Leiden University, you must meet the following admission requirements.

To be eligible for Physics and Science Communication and Society at Leiden University, you must meet the following admission requirements.

To be eligible for Physics and Classical/Quantum Information at Leiden University, you must meet the following admission requirements.

To be eligible for Research in Physics, theoretical at Leiden University, you must meet the following admission requirements.

To be eligible for Research in Physics, Quantum Matter and Optics at Leiden University, you must meet the following admission requirements.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Promotor: V. Vitelli, Co-promotor: J. Paulose

What is the role of emotion regulation in coping with interpersonal feedback?

The research programme Industrial Ecology aims to support the ecological transformation of society and environment towards sustainability. The research subject is Industrial Ecology in its broadest definition, covering environmental systems analysis, and incorporating the social and economic aspects…

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

Valentina Carraro explores the relationship between overlapping UN human rights institutions, specifically the treaty bodies and the Universal Periodic Review (UPR)

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: Prof. dr. V. Vitelli

On May 31st, Bobby Ruijgrok succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Bobby on this great result.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Promotor: Roeland M.H. Merks

The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

On May 23rd, Ernanda succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Ernanda on this great result.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

The research of the unit is aimed at the development of models to explain and describe the influences in social systems. Social influences are studied in three ways: from the perspective of group dynamics, from an individual-cognitive perspective, and from an economic and consumer psychological pers…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).