If doctors could better estimate a patient's chances of survival, this would help in choosing a specific treatment. It would be particularly beneficial for the rare and malignant Ewing sarcoma, which mainly affects children and adolescents. Mathematics professor Marta Fiocco has been awarded a substantial…

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

A full overview of MCBIM PhD theses.

Late in 2015 a woman gave birth to a baby conceived following the reimplantation of thawed ovarian tissue. The woman was able to become pregnant thanks to transplantation of the tissue that took place in the LUMC.

Hoe kijken Nederlandse bedrijven naar online prijsdiscriminatie? Kimia Heidary, Bart Custers, Helen Pluut en Jean-Pierre van der Rest schreven hier een artikel over.

Veel mensen denken dat zware metalen giftig zijn en mens en natuur altijd schade aanbrengen. Dat beeld moet genuanceerd worden, vindt hoogleraar Sylvestre Bonnet.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

With cancer, the immune system is a double-edged sword: it can attack tumour cells, but can also help them grow and spread. It is a question of harnessing it. This is what Professor Karin de Visser argued in her inaugural lecture on 15 November 2019.

Researchers at Leiden University have demonstrated that tumours can apply mechanical means to attract the blood vessels they need to be able to grow. The team published this discovery on 2 March in Nature Scientific Reports.

Strengthening a cancer patient's own immune system so that the body itself can better destroy cancer cells. This is at the heart of immunotherapy, the most promising progress in cancer treatment in recent years. In order to drive this development further, the Netherlands Cancer Institute-Antoni van…

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Valedictory lecture

Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

A consortium of research groups, including that of LACDR professor Erik Danen, will use an NWO Perspective grant of nearly five million euros to build a universal standard for organ-on-chip models. They aim to stimulate the application of these chips in the biomedical and pharmaceutical industry. Danen…

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

PhD student Janine Westendorp and her colleagues conducted literature research on what patients with cancer and their loved ones perceive as harmful communication from healthcare providers. The results were published in the journal Psycho-Oncology and are released as a poster to distribute to healthcare…

Chemotherapy, but without hair loss or extreme fatigue. It may be possible if the toxic drug only becomes active where it is ‘switched on’ by light. Matthijs Hakkennes has helped bring that idea closer to reality and obtained his PhD cum laude. ‘I received many thank-you emails from China and Bangla…

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

The Leiden Institute of Physics has been awarded three out of twelve available grants from the FOM Projectruimte. Principal Investigators Milan Allan, Stefan Semrau and Carlo Beenakker all receive around 400,000 euro for their research.

Nausea, neurologic pain and hair loss: some of the severe side effects of chemotherapy. Not necessary, biochemist Liyan Zhang showed. Together with Leiden biologists and others, she achieved great results with a drug that is only active in combination with light. Zhang will defend her PhD on 4 July.

Our Principal Investigator Bart Barendregt is also UNESCO Chair in the Anthropology of Digital Diversity.

A month ago it was Marc Baggelaar, and now Hans Kistemaker too has obtained his PhD cum laude at the Leiden Institute for Chemistry (LIC). ‘He has made ground-breaking contributions to the world of protein modification,’ says PhD supervisor Gijs van der Marel. Kistemaker obtained his PhD on 11 May…

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

A team led by Erik Danen from the Leiden Academic Centre for Drug Research has received a 3 million euros NWO Science Groot grant to unravel the first steps of metastasis. Danen will work together with biologists and theoretical and experimental physicists from Dutch Universities. ‘Understanding these…

eLaw is a research institute of interdisciplinary scholars who explore issues at the intersection of law, technology and society.

Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…

Lecture

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

Key publications of the Cancer Drug Target Discovery group

New or improved treatments for chronic and acute illness.

Discovery of metastasis promoting candidate drug targets

An overview of the research at the Cancer Dug Target Discovery group.

Sonic Modernities situates Southeast Asian popular music in specific socio-historical settings, hoping that a focus on popular culture and history may shed light on how some people in a particular part of the world have been witnessing the emergence of all things modern.

Over time Dutch and Indonesian composers, performers and music scholars have inspired each other and they continue to do so. The presence of the Dutch in the Netherlands East-Indies and Indonesia, but also the existence of large diasporic communities in the Netherlands have contributed to a mutual exchange…

Improving health, enhancing well-being and reducing health disparities across society.

Audiovisual and Digital Ethnography is a state-of-the-art introduction to this dynamic and growing subject. The authors explain its fundamental aspects in a clear and systematic way.

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Four researchers from Leiden University have been awarded NWO Open Competition grants in the Science domain. This is for research into subjects such as immune cells in tumours, antibiotic resistance and magnetic semiconductors.

Pathways of toxicity

Overview of the Leiden Asia staff per area or country.

In Democratie en totalitarisme zijn de invloedrijkste opstellen van de Franse denker Claude Lefort samengebracht. Lefort laat overtuigend zien dat de kwetsbaarheid van de democratie juist ook haar kracht is. Voor democratie is essentieel dat de macht als ‘lege plaats’ verschijnt. Zij mag slechts tijdelijk…

From the 11th of May Ewa Snaar-Jagalska has been appointed Professor in the field of cellular tumor biology within the Faculty of Science at the Institute of Biology Leiden. Her research focuses on the cellular tumor biology and human cancer modeling in zebrafish