955 search results for “brein cancer metastasis” in the Public website
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Towards the Prevention of Cancer Treatment Related Hearing Loss
PhD defence
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T-cell gene therapy for low mutational burden cancer
PhD defence
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Understanding anthracycline action: molecular insights to improve cancer therapy
PhD defence
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Insights into gastric cancer: towards tailored surveillance and treatment strategies
PhD defence
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Blueprints of Disease: Precision Platforms for Modelling Breast Cancer
PhD defence
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Predicting and evaluating side effects of radiotherapy in cervical cancer
PhD defence
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Modeling and Targeting Tissue Dynamics in Fibrosis and Cancer
PhD defence
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Data-driven approaches to study breast cancer metabolism
PhD defence
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On preoperative systemic treatment of muscle-invasive bladder cancer
PhD defence
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Awards and Grants 2017
An overview of awards and prizes granted to our staff and students in 2017, as well as special appointments and royal distinctions.
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Life Science & Technology (MSc)
Improved molecular knowledge of the mechanisms of processes in the cell can lead to better medicines and new or advanced methods for combating diseases. Our MSc students in Life Science and Technology (LST) specifically learn to understand the molecular and structural chemical and biological aspects…
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How bacteria survive with almost no oxygen
Researchers in Leiden have, for the first time, observed how a specialised enzyme helps bacteria stay alinve when oxygen levels are low, and how that process can be blocked. The discovery opens up new possibilities for targeted antibiotics.
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Daisy Batenburgd.batenburg@lacdr.leidenuniv.nl | 071 5272727
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Kim Elbertsek.elbertse@lacdr.leidenuniv.nl | 071 5272727
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Elsa Neuberte.neubert@lacdr.leidenuniv.nl | 071 5272727
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Jeroen Jansenj.c.jansen@lumc.nl | 071 5269111
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Andraniek Evadgian -
Alfred Vertegaala.c.o.vertegaal@lumc.nl | 071 5269111
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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High school programmes
The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Centre for Microbial Cell Biology
The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.
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Activity-Based Proteasome Profiling
Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea
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Overview
The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
Source: J Cheminform, Volume 7, Issue 1 (2015)
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Introduction
Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Synthetic Affinity-Based Probes for ADP-Ribose Interactome Studies
Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.
- Events
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ERC Consolidator Grants for four Leiden researchers
The European Research Council has awarded ERC Consolidator Grants to four researchers from Leiden. These grants of up to 2m euros will enable them to continue and expand their research.
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Anne-Laura van Harmelen talks about resilience and public engagement on Dutch radio
In a one-hour interview on Dutch radio programme Sleutelstad, Anne-Laura van Harmelen talks about her research into the role friendships in adolescents' well-being, the resilience paradox and the role of social, hormonal and genetic factors in stress-levels and resilience.
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Eveline Crone in the media
In the Dutch media lots of articles have recently appeared based on interviews with Eveline Crone about the adolescent brain.
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Facts and myths about resilience after childhood adversity
Anne-Laura van Harmelen, professor Brain, Safety and Resilience will give her inaugural lecture ‘Resilience does not exist’ (in Dutch) on Monday 27 June. In her inaugural lecture she will discuss resilience after childhood adversity.
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Anne-laura van Harmelen about the 'Yes! No!' game over the term resilience
In Dutch magazine De Psycholoog, Anne-Laura van Harmelen talks about the use of the term resilience and argues that resilience is concept that needs further explanation.
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Veni grants 2012
Three researchers at LUCL have been awarded a VENI-grant by NWO.
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Anne-Laura van Harmelen: In the media
Stay tuned for updates on relevant media appearances of Anne-Laura van Harmelen.
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Niko Tinbergen lecture 2019: Stem cells, mini organs and eternal life
Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.
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Jenny AudringFaculty of Humanities
j.audring@hum.leidenuniv.nl | 071 5272247
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Healthy ageing
The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology
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SAILS
SAILS (Society, Artificial Intelligence and Life Sciences) is a universitywide initiative aimed at facilitating collaboration across disciplines on the use of Artificial Intelligence (AI). It is one of Leiden University's interdisciplinary programmes.
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The scientists behind LED3
Meet the scientists within the LED3 community
- Research Dossiers
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Niall Hodgins best Student Entrepreneur
Niall Hodgins, master student Biology and Science Based Business, has earned the right to call himself the best student entrepreneur in Leiden. On June 15th 2016 he won the finals of Gulliver and the associated 10,000-euro prize for his company NADES to continue developing solvents for use in preclinical…
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Neuropsychologist Mariska Kret through to top 5 Science Talent
Neuropsychologist Mariska Kret is through to the next round in the 2016 Science Talent contest organised by New Scientist magazine.
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Workshops & Demo's
During the Leiden Science Family Day, you can take part in various workshops. You can also watch various demonstrations. Where will you go?