Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Professor of Radiology Andrew Webb and his collaborative partner Johnes Obungoloch from Uganda have won the 2023 Huibregtsen Prize.

50 years ago Lauterbur published the basic principle of MRI. Sine then MRI has become more expensive. Professor Andrew Webb describes what is needed to make MRI available for everybody.

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

This dissertation examines what network in the human brain is involved in the perception of prosody and whether activity within this network is modulated by the personality trait alexithymia.

With his ice-cold nano force sensor, Tjerk Oosterkamp searches for the boundary between the quantum world and the everyday world. The Leiden physicist has received an NWO subsidy of 600,000 euros.

Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

The Leids Astronomisch Dispuut F. Kaiser is an association dedicated to the students who study astronomy in Leiden. In addition, they are also very involved in the public activities in the Old Observatory and help with the development and implementation of other projects in the building.

Promotores: Bas Edixhoven, Guy Henniart

A new NMR microscope gives researchers an improved instrument to study fundamental physical processes. It also offers new possibilities for medical science, for example to better study proteins in Alzheimer patients’ brains. Publication in Physical Review Applied.

The philosopher and psychologist G.F. Stout was the teacher of Moore and Russell around 1894. This book shows that Stout's ideas have played a role in Moore and Russell's development from their early idealism towards analytic realism, where Stout's ideas often find their origin in early phenomenolog…

Novel language learning activates different neural processes than was previously thought. A Leiden research team has discovered parallel but separate contributions from the hippocampus and Broca's area, the learning centre in the left hemisphere. The right hemisphere of the brain also seems to play…

The updated MRI scanner at the Leiden Institute for Brain and Cognition (LIBC) will become operational on 29 September. The new version is faster and better than the current model.

In October 2019, OSCL organised a Hackathon on the ins and outs of MRI datasharing

Kan artificiële intelligentie (AI) helpen om subtiele veranderingen in de gewrichten op te merken op MRI-beelden van patiënten met reumatoïde artritis? Die vraag gaan Leidse wetenschappers beantwoorden dankzij een subsidie van de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).

Research facilities within reach of LIBC members:

Leiden University Medical Center (LUMC), Leiden University and Philips are jointly receiving over 2 million euros from NWO to set up an artificial intelligence (AI) lab. The aim of this lab is to accelerate and improve MRI scans with AI. This is great for patients, and it helps make MRI more accessi…

Professor Andrew Webb has been appointed Simon Stevin Master 2017 by the Netherlands Organisation for Scientific Research, an award that carries a prize of 500,000 euros. Webb, who is Professor of MRI Physics at Leiden University Medical Center (LUMC), will use this funding to focus on developing new…

Een samenwerking tussen het Leids Universitair Medische Centrum (LUMC), de Universiteit Leiden en Philips ontvangt financiering van wetenschapsfinancier NWO om MRI-scans te versnellen. Deze drie partijen vormen samen een van de 17 AI-labs die onder de naam ROBUST voor een periode van 10 jaar NWO-steun…

Together, Leiden University Medical Center (LUMC), Leiden University and Philips are one of the 17 AI labs within the ROBUST consortium that will receive support from the Dutch Research Council (NWO). The aim of this collaboration is to use artificial intelligence to speed up MRI scans.

Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.

Labour law is constantly changing. Concurrently, the laws dealing with workers address fundamental issues which are invariably of major significance and value. The research carried out at the Department of Labour Law and Social Security focusses on both the (constant) changes in labour law and social…

Overview of the main research projects at the Leiden Papyrological Institute.

How do practice and theory reinforce one another in neuroscience? Professor Birte Forstmann’s inaugural lecture on 2 October will be about building interdisciplinary bridges between cognitive neuroscience and cognitive models. Her approach may lead to brain research with fewer side-effects for patie…

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

At Leiden University, researchers from all disciplines work together to find answers and design innovations in the field of artificial intelligence.

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

Serge Rombouts is a physicist whose PhD thesis was about functional MRI (fMRI). This visualises activity in regions of the brain. The appealing images of glowing brain regions that emerge from the computer are the result of calculations. According to Rombouts, this isn’t proper artificial intelligence.…

The research of the Mathematical Institute is driven by the curiosity of its members and has many internal and external connections. It can be characterised as fundamental but with an open attitude towards applications.

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

How can collaborative participatory action research by student-teachers and their students enhance student participation, improve educational practices, and generate knowledge about these practices that can be used for improving teacher education as well?

How do academics develop into novel researcher roles alongside current teacher roles in the context of new universities in transition?

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…