How can the transport of molecules in living cells help to target medicines at exactly the right place?

Leiden University, Department of Economics

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

An overview of research projects at the Predictive Pharmacology group.

How are digital risk-profiles developed and used in practice?

This project investigates the globalization and cultural mediation of palliative care practices, policies and discourses.

A large amount of the EU's used or wasted textile is exported towards lower-income countries. Much of this exported textile is either burned or dumped and the amount that is truly reused or recycled is uncertain.

The LOFAR e-infrastructure group is responsible for deploying and maintaining LOFAR processing on distributed e-infrastructure. A co-operation between SURFsara, Leiden University and ASTRON, the group develops software to integrate the LOFAR stack with processing pipelines. Our software can schedule…

This project employs a systematic experimental approach to examine the interaction of these two hitherto independent lines of research (tone sandhi and focus realization) in six dialects of Chinese, which lie on a continuum between dialects with dense tonal distributions and sparser distributions. In…

This paper explores whether multilateral surveillance and policy coordination under the ES was based on a path-changing or a path-dependent mechanism

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

ASLU 11

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

This article by Honorata Mazepus and Florian van Leeuwen in the journal Governance: An International Journal of Policy, Administration and Institutions looks at how evaluations of authorities were influenced by four aspects of a governmental response to a hypothetical disaster.

Promotor: P.D. Grünwald

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

The arrival of Columbus to the Caribbean in 1492 marked a milestone in world history. In both the European and the indigenous world, a set of economic, political and hierarchical networks and relations were defined, structured and changed. These changes affected the indigenous population at different…

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Planets are formed in disks of gas and dust around young stars.

This dissertation investigates ikat from the eastern Indonesian islands from a uniquely technical perspective, including design analysis of asymmetry and microscopy.

In times of hardships or crisis, local people know how to deal with it using their resourcefulness. Although efforts are sometimes made by the government to help them, they are fully aware that community support is at least equally important.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Material culture and the role of rural communities in exchange systems of the eighth and ninth centuries

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Promotor: T. Schmidt

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Promotor: Prof.dr. A.W. van der Vaart

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

An analysis of pot decoration and hut distributions from the Central European Neolithic communities of Elsloo and Hienheim.

“Neighborhood solidarity cannot compensate the absence of the State: a response from the local administration is needed”

A high performance computer or supercomputer owes its massive processing capacity to the fact that it chops a single overarching task into a whole series of smaller tasks. It simultaneously tackles each of those smaller problems.

The centralized LUMC biobank department helps to implement rules and regulations regarding informed consent, collection, storage and distribution of biomaterials and data for biobanking.

The author researched the motivations of bureaucrats to integrate refugees into welfare services even when they do not have any legal obligation to do so.

What is the iconography of propaganda specifically as it relates to the historical development of political ideologies in modern Egypt and how was/is this propaganda disseminated among creative fields such as cinema, art, monuments, architecture, and literature?

Smart digital infrastructures predicated on myriads of sensors distributed in the environment are often rendered as key to contemporary urban security governance to detect risky or suspicious entities before or during a criminal event takes place. At the same time, they often involve surveillance of…

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

The wealth of shoes, sandals and other footwear from ancient Egypt is poorly understood due to lack of research. This is remarkable, because from the very beginning of Egypt’s long history footwear served practical as well as more spiritual purposes.

Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high- or infinite-dimensional models and data.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

ASLU 13

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.