Developing and investigating statistical methods for complex data and models

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Are you thinking about studying Statistics and Data Science? Learn more and watch the introduction video.

This study looks at the question of how and at what level students in primary teacher education can integrate theory and practice, and how the organisation of their learning environment, focusing especially on mathematics and pedagogy, can contribute to that.

The master’s specialisation Mathematics and Education at Leiden University prepares students to teach the subject of mathematics to secondary school students. The programme comprises a one-year mathematics component, followed by an education component in the second year.

Scientific staff of the Mathematical Institute organises the General Mathematics Colloquium several times a year.

Promotor: R.D. Gill, F. Taroni

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

In this dissertation, Boethius’ mathematics and logic and their roles in philosophy are reassessed, and on the basis of these, the connections between mathematics and logic in Boethius and their applications to theological or philosophical topics are explored.

Welcome to StatiCS: the Statistical Consultation Service. The goal of the service is to provide statistical support to PhD candidates and other researchers.

Data science is now growing fast in many places, but scholars at Leiden University have been developing data science techniques for a long time already. Thanks to their broad-based expertise, Leiden statisticians are currently combining the achievements in statistics with the latest methods of statistical…

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

The master’s specialisation Mathematics and Science Based Business at Leiden University bridges science and business development by focusing on areas such as technology management, innovation, entrepeneurship, operations, and decision making.

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).

Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…

Promotor: P.D. Grünwald

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

In this thesis, we examine various systems through the lens of several numerical methods.

This is a research project on the implementation of national mathematics curriculum reform in Chinese junior high school. The research is expected to provide insight into the ways and reasons of mathematics teachers in Chinese junior high school for implementing national curriculum reform.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Two Leiden researchers have demonstrated how mathematics can improve our healthcare. Daniel Gomon has developed a model that contributes to the quality of care in hospitals. Marta Spreafico works on an app that helps physicians make well-informed decisions about the treatment of a certain type of cancer.…

The master’s specialisation Mathematics and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in mathematics with extensive training in science communication.

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Promotor: R. Gill, Co-promotor: P. Massart

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Roeland M.H. Merks

He is said to be one of the greatest living statisticians. Bradley Efron gave a lecture in Marekerk and opened LUXs, the Leiden University Center for Statistical Science, the first university statistics centre in the Netherlands.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

Promotor: Prof.dr. G.R. de Snoo