2,100 search results for “mathematical and statistical modelling” in the Public website
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Wouter van Loon
Faculteit der Sociale Wetenschappen
w.s.van.loon@fsw.leidenuniv.nl | +31 71 527 2727
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Cheating graphs: a lesson in statistics without arithmetic
Missing legends, illogical connections or three-dimensional graphs. There are many ways in which data can deceive. Five students took up the fight against misleading statistics. Their lesson series can now be found online.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Martin Bright
Science
m.j.bright@math.leidenuniv.nl | +31 71 527 7132
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Ronald Cramer
Science
cramer@math.leidenuniv.nl | +31 71 527 7047
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Marco Streng
Science
streng@math.leidenuniv.nl | +31 71 527 7093
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M Bhargava
Science
m.bhargava@umail.leidenuniv.nl | +31 71 527 2727
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Emma Brakkee
Science
e.l.brakkee@math.leidenuniv.nl | +31 71 527 2727
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Peter Bruin
Science
p.j.bruin@math.leidenuniv.nl | +31 71 527 7142
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Hendrik Lenstra
Science
hwl@math.leidenuniv.nl | +31 71 527 7127
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David Holmes
Science
holmesdst@math.leidenuniv.nl | +31 71 527 7133
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Non-Abelian metamaterials: emergent computing and memory
In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.
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Marjolein Fokkema
Faculteit der Sociale Wetenschappen
m.fokkema@fsw.leidenuniv.nl | +31 71 527 7996
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Continuation Dutch mathematics clusters
Starting from September, the four Dutch mathematics clusters DIAMANT, NDNS, GQT and STAR will each be given 1 ME from NWO Exact Sciences, to be spent within a period of two years.
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Using a practical teaching model by beginning teachers learning to design lessons.
Beginning teachers often experience difficulties making activating lessons. This study investigates how and if the practical teaching model can offer them a hand in learning to design lessons.
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Career prospects
A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.
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Why Leiden University?
Our programmes are known for our scientifically based education and for our open atmosphere.
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Why Leiden University?
Our programmes are known for our scientifically based education and for our open atmosphere.
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Why Leiden University?
Our programmes are known for our scientifically based education and for our open atmosphere.
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Why Leiden University?
Our programmes are known for our scientifically based education and for our open atmosphere.
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Why Leiden University?
Our programmes are known for our scientifically based education and for our open atmosphere.
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Why Leiden University?
Our programmes are known for our scientifically based education and for our open atmosphere.
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
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Constructions Emerging: A Usage-Based Model of The Acquisition of Grammar
This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Modelling phonologization: Vowel reduction and epenthesis in Lunigiana dialects
This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
M. Danhof, Co-promotor: O.E. Della Pasqua
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Néron models in high dimension: nodal curves, Jacobians and tame base change
We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Assessor-Centered Translation Quality Assessment: A Theoretical Model and a Case Study
Behrouz Karoubi defended his thesis on 15 June 2016
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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An ex vivo human skin model for studying skin barrier repair
In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.
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Laboratories for Digital Archaeology
The Digital Archaeology research group manages two computer laboratories with different purposes: the teaching lab (F1.01) and the research lab (A1.13a).
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Inventing anchors? The function of ‘Greek models’ within the process of innovation in Early Roman Drama
To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?
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Research
Research of the Methodology & Statstics unit of the Institute of Psychology at Leiden University.
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of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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Impact assessment modelling of matter-less stressors in the context of Life Cycle Assessment
Promotores: Prof.dr. G.R. de Snoo & Dr. R. Heijungs
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Ada Lovelace Distinguished Lecture Series
The Ada Lovelace Distinguished Lecture Series brings outstanding computer scientists from around the world to Leiden University. The lecturers will share exciting ideas and results from the forefront of computer science.
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Model-assisted robust optimization for continuous black-box problems
Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.
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‘Ūd Taqsīm as a Model of Pre-Composition
In this research project Nizar Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).
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underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Admission and Application
Are you interested in studying the Methodology & Statistics in Psychology master's programme at Leiden University? Find out how to apply by following the step-by step guide in the application and admission section.