How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

Amir Zamanipoor Najafabadi, a doctor and researcher at the LUMC’s Department of Neurosurgery, researches how meningioma treatment can have a long-term effect on a patient’s life. He recently defended his dissertation: with a patient on the examining committee, this was a unique occasion.

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

How can we best treat infectious diseases in people with obesity? Hospital pharmacist and PhD researcher Koen van Rhee studied how obesity affects blood levels of two commonly used medicines. He also developed a method for pharmaceutical companies to test new drugs on this patient group.

Patients who feel understood will recover faster. But how can doctors become more empathetic? By reading literary works, suggests emeritus Leiden Professor of Medical Psychology, Ad Kaptein. He discusses this issue in his book ‘Helende woorden – romans over ziek-zijn’ (Healing words - novels about…

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Technological innovations such as home dialysis could significantly improve the quality of life and health of kidney patients. Professor Joris Rotmans therefore wants to continue pushing for new medical technology, as he will explain in his inaugural lecture on 24 March.

PhD defence

PhD defence

PhD defence

PhD defence

We are pleased to announce a call for papers for a conference focused on ethical practices in medical research and treatment in the colonial and postcolonial context.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

PhD defence

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…

Lecture, Tuesday Talks: Science Insights

In this project we ask: how does pollution manifest as part of different practices, both socially and materially.

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…