283 search results for “drug discovery” in the Staff website
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300 million euros for new international stem cell consortium
The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…
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Status update in the evolutionary race between humans and resistant bacteria: two steps forward for us
A patent for what may be a potent, new antibiotic. And: a clear overview of promising approaches to overcome a crucial resistance tactic employed by bacteria. In the span of one week, two researchers from Leiden are receiving their PhDs, each of them on an important step in the battle against bacteria…
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‘Sleep should play a greater role in lifestyle research’
Sleep disorders have a significant influence on our physical and emotional health. Sleep should therefore receive more attention within lifestyle medicine, says Professor Gert Jan Lammers. He will give his inaugural lecture on Friday 20 May entitled: ‘Getting to sleep’.
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Targeting the immune system to inhibit atherosclerosis
A new treatment for atherosclerosis showed promising results in isolated cells but proved to be less effective in initial animal tests. Bachelor student Biopharmaceutical Sciences Willemijn van der Heijden aimed to understand why. She investigated whether the formation of a protein layer around the…
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Executive Board column: Annetje Ottow on the importance of student associations
Now the introduction weeks can go ahead as usual, the new students’ enthusiasm is overwhelming. It’s back to normal for the student associations too, having had a hard time of it during the pandemic.
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GTGC lunch seminar series: an international, interdisciplinary scope
Starting February 6, the Leiden interdisciplinary research programme Global Transformations and Governance Challenges (GTGC) will host a lunch seminar series on pressing global governance issues. The series will feature researchers from various disciplines. It promises to be a trove of inspiration and…
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Kiem project investigates link between violence and other health problems
‘Violence as a Population Health Problem’ is one of 33 interdisciplinary projects that have been launched thanks to a Kiem grant. The project team will analyse a large patient database to identify links between violence and other health problems. ‘Violence can also be an expression of other factors,’…
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Biology student Martijn Verkuilen wins Unilever Research Prize
Martijn Verkuilen is the winner of the Unilever Research Prize 2022. By transferring DNA from a plant into yeast, he made the first move to produce a new drug for type 2 diabetes. He collected his prize in Wageningen on 24 November.
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PhD Graduate Van Groesen: ‘Nothing is too crazy to try.’
In a world where bacteria are increasingly resistant to antibiotics, Emma van Groesen set out to find a solution. This month she obtained her PhD, after four years of research into new variants of the antibiotic vancomycin. With success.
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Three awarded research projects in NWO-XS call
Cryogenic memories, antibiotic treatment for urinary tract infections and recycling plastic sustainably. These are the subjects of the three NWO-XS grants awarded to Leiden Science researchers.
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How do we get the we-feeling on the faculty? This is how Joost Batenburg thinks
As professor of computer science at LIACS and programme director of incentive programme SAILS, Joost Batenburg knows better than anyone what is going on in the faculty. Over the past three years, he learned at lightning speed what is going well and where sensitivities lie. 'We need to move more towards…
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Leiden researchers visualise the 'guardian of our genome’
The guardian of our genome, the protein MutS, scans the DNA for spelling errors and makes sure they are corrected. An essential process for our health. Researchers at Leiden University Medical Centre (LUMC) have discovered precisely how this protein works by making MutS visible with cryo-electron microscopy.…
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Flu stops when you block the enzyme that cleaves off virus particles
A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.
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Researchers tackle antibiotic-resistant bacteria
When a bacterium becomes more resistant to one antibiotic, it sometimes becomes more sensitive to another. To better understand this interaction, researchers from the Leiden Institute of Biology (IBL) and the Leiden Academic Center for Drug Research (LACDR) under supervision of Daniel Rozen and Coen…
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Wall Formula Tours
Arts and culture, Tour
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Optimizing antifungal treatment through pharmacometrics: dosing considerations for enhanced efficacy
PhD defence
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Improving Nature’s Antibiotics to Overcome Resistant Bacteria
Lecture, NGL-lezing
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CCLS Seminar
Lecture, seminar
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Triblock Polypept(o)ides for siRNA Delivery
PhD defence
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Celebrating science on our Faculty with sparkling Leiden Science Family Day
Elephant toothpaste, a trip among the stars or a lecture on mathematical juggling: on Sunday 8 October 2023, the Faculty of Science opened its doors for the third edition of the Leiden Science Family Day. A programme jam-packed with workshops, demonstrations, lectures and peeks behind the scenes for…
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Jasper's day
Jasper Knoester is the dean of the Faculty of Science. How is he doing? What kinds of things is he doing and what does his day look like? In each newsletter Jasper gives a peek into his life as dean.
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Space telescope Euclid makes first test images - astronomers are full of anticipation
The two instruments of ESA's space telescope Euclid have taken their first test images. The first images indicate that the space telescope will achieve the scientific goals for which it was designed - and possibly much more. Euclid will create a 3D map of a third of the sky, allowing scientists to study…
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Leiden students develop highly contagious card game
Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…
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‘Look beyond your own discipline’
Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.
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Jasper's day
Jasper Knoester is the dean of the Faculty of Science. How is he doing? What kinds of things is he doing and what does his day look like? In each newsletter Jasper gives a peek into his life as dean.
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Paco Barona Gomez ready to work in Leiden: ‘Fundamental research creates opportunities’
Paco Barona Gomez is the newest associate professor at the Institute of Biology Leiden (IBL). The Mexican researcher is fascinated by the evolution of natural products: compounds made by microbes, but also plants and animals. ‘It’s like we investigate chemical dark matter.’
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'Only when you give students freedom, exceptional results are possible'
It doesn't happen every day that the research project of a first-year bachelor’s student results in a scientific publication. And not only that, but as first author and on the cover of a leading physics journal. ‘We have given our lab education a thorough overhaul and it is paying off.’
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New eDNA method opens doors for environmental research
With a single sample of water or soil, researches can analyse the DNA of everything that is living in that environment. During her research, PhD candidate Beilun Zhao discovered a way to analyse not only the kind of species, but also the age of the species in a water sample. The method showed its first…
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ERC Consolidator Grants for Leiden researchers
Five Leiden researchers have been awarded a Consolidator Grant by the European Research Council (ERC). This grant of up to two million euros will enable them to continue and expand their scientific research.
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Singing parrots wanted: is our musicality unique?
Is our musicality unique? That’s what the Bird Singalong project aims to find out. And for that, they need the help of feathered friends from all around the world. ‘By researching how parrots learn songs, we also learn more about the origin of our own musicality.’ Do you have a parrot that can sing…
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How oak seedlings teach us more on dune restoration
What is the best way to restore dune ecosystems? The project TERRA-Dunes researches the role of soil microbes in the development of natural dune areas. Recently, the project went into a new phase: planting 412 oak seedlings grown in different type of soils.
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Dust cloud from two colliding ice planets dims light of parent star
For the first time, an international group of astronomers have seen the heat glow of two ice giant planets colliding. They could also observe the resultant dust cloud move in front of the parent star several years later. Led by Leiden astronomer Matthew Kenworthy, they monitored the star's brightness…
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Award of 33 Kiem grants for new interdisciplinary initiatives
No fewer than 55 applications were submitted for a Kiem seed grant, an initiative for developing new interdisciplinary, interfaculty research partnerships and encounters. The draw took place on Monday for the allocation of 22 seed grants. The Executive Board was so impressed with the number of applications…
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Anoma van der Veere did Japanese Studies at Leiden University
Alumnus Anoma van der Veere did Japanese studies and talks in this interview about his studies in Leiden and his work as a researcher at the Leiden Asia Centre and as Japanese correspondent in Tokyo.
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Biology brothers write book about nature and adventure in Eastern Europe: 'I didn't know there live pelicans in Romania'
With a self-converted red camper van, biologists and twin brothers Kevin and Marvin Groen go on a nature adventure in Eastern Europe. Together, they search for wild animals, beautiful nature and places to sport. From a long search for a bear in the Slovakian wilderness to the discovery that pelicans…
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…
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Spinoza and Stevin Prizes for three Leiden professors
Three Leiden professors have recently been awarded the most prestigious scientific accolade in the Netherlands: Maria Yazdanbakhsh and Marc Koper have been awarded a Spinoza Prize and Judi Mesman a Stevin Prize. They received their prizes on 13 October.
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CML's Stans Award 2021
CML grants three Stans Awards each year, known as the best PhD paper, best student thesis and best outreach from the past year. The CML staff nominated students and colleagues and this year’s jury Prof.dr. Koos Biesmeijer and Prof.dr. Nicole de Voogd made the final decision.
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Is there oxygen on exoplanets? New telescope finds out
To what extent does exoplanet Proxima b resemble our Earth? And is there some form of life present? Astronomers hope to find answers to these questions with the new European Extremely Large Telescope (ELT). An NWO research grant of €18 million will allow a Dutch consortium to continue building instruments…
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Leiden Classics: Bibliotheca Thysiana, a 17th century time machine
From once controversial scientific works and historical bibles, to personal shopping lists and clothing bills. The 17th-century Bibliotheca Thysiana and the archive of the collector Johannes Thysius exhibit both the intellectual and everyday life as it was three hundred years ago. Now a brand-new digital…
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FLAMINGO: dark matter, ordinary matter, and neutrinos in the biggest cosmological simulation ever
Not only dark matter, but also ordinary matter and dark energy are tracked in the largest ever cosmological computer simulation ever. In the FLAMINGO simulations, you can see virtual galaxies and clusters of galaxies emerging over the course of billions of years. This is no easy task: with more than…
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Stunning James Webb images show birth and death of massive stars
The James Webb Space Telescope continues to surprise us with stunning pictures, but of what exactly? Astronomer Nienke van der Marel shows with three images how massive stars lead short but explosive lives.
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Curing diseases with lab-grown organs
Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…
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Post-quantum cryptography should keep our DigiD, bank accounts and state secrets safe
Our banking, DigiD and sensitive medical data: what if our entire digital infrastructure can no longer be trusted? Jelle Don has this question permanently in mind as he goes about his research. And that is no bad thing because without new digital security measures, our society will be extremely vuln…
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How NeCEN helped develop the Johnson & Johnson Covid-19 vaccine
The Phase 3 clinical trial results of the promising Covid-19 vaccine of Johnson & Johnson are expected this month. The Dutch electron microscopy facility NeCEN helped develop the company’s vaccine, and they have now published their scientific findings in Nature Communications.
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How to make cryptographic techniques more efficient?
Sharing scientific data, transferring money, or sending other sensitive information online: with cryptography, applications make sure your data does not fall into the wrong hands. Mathematician Thomas Attema (CWI/TNO/Leiden University) helps with this. For his PhD research, he developed a new technique…
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New statistical method brings together studies at an early stage
During the coronavirus pandemic, scientists were in a hurry to find drugs that would help fight the disease. To combine the research that was being carried out around the world, PhD candidate Judith ter Schure developed a new statistical method: ALL-IN meta-analysis. This helps determine sooner whether…
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Organ failure caused by viruses, how does it work? Now there are methods to find out
Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…
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Using low sample volumes to better understand brain diseases
Marlien van Mever delved into the analysis of tiny samples, cerebrospinal fluid from transgenic mouse models for example. She validated methods that can now be used to study brain diseases such as migraine and epilepsy. Van Mever will receive her PhD on 14 June.
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Veni grant for ten Leiden researchers
Ten Leiden researchers have been awarded a Veni grant by the Dutch Research Council (NWO). The grant, of up to 280,000 euros, will enable them to elaborate their ideas over a period of three years.