Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

How do societies move forward with sustainable, effective and efficient management of Earth's water resources?

Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.

On 27 January 2022 Tjahjono Prasodjo successfully defended a doctoral thesis and graduated.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Leiden University is committed to reducing our water consumption.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

We investigate water quality and want to understand the effects of human interference on aquatic biodiversity.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Improving environmental risk assessment of pesticides in surface waters

Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.

Overkleeft

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

How can the Safe and Sustainable by Design (SSbD) framework developed in the SSbD4CheM project facilitate the creation of safer and more sustainable chemicals and materials across various industries?

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Lecture

This project investigates ancient water management of streams, springs and runoffs on the archaeological site of Monte Albán, Mexico, as a means to contribute with different stakeholders in the development of sustainable solutions to water problems today such as floods and scarcity.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

AI:Liner develops cutting-edge digital solutions for sewer asset management while ensuring responsible AI adoption through comprehensive social science research and ethical frameworks.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

How do chemical contaminants traverse and affect terrestrial biodiversity and ecosystems?

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

How does the vision of problems and solutions from

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Amerindian intra- and inter-insular relationships and social organization in the pre-colonial Windward Islands.

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…