In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…

Dialysis patients experience a range of physical and mental symptoms that interact and influence each otherIn her doctoral research, psychologist Judith Tommel wanted to find the optimum approach to help these dialysis patients improve their quality of life. ‘We need to make sure we avoid excluding…

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome, and which interventions are effective in influencing these factors?

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Public sector decision-makers operate amidst an abundance of information and unclear political objectives. Attention is the sine qua non of policy-making: What is attended to can be addressed in policy responses; what is overlooked or goes unnoticed cannot. Despite its importance, public administration…

An e-coaching programme helps people with chronic kidney disease, particularly in areas that patients themselves want to work on. ‘A healthy lifestyle is important for patients with kidney disease: it can slow down the loss of kidney function and there will be fewer complications,’ Katja Cardol explains…

On 1 July 2020, Niek Strohmaier defended his thesis 'Making Sense of Business Failure'. The doctoral research was supervised by Prof. J.A.A. Adriaanse en dr. H. Pluut.

Dr. Nikki Ikani challenges binary views of intelligence warnings, proposing a multidimensional typology to evaluate warning effectiveness.

Kidney transplantation used to be an experimental risky procedure, but is now routinely performed by many countries worldwide.

Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…

There are about 35,000 students with chronic illnesses in the Netherlands. If they cannot receive education in the classroom, they may be able to do so from home or a hospital with hybrid education. The question in this study is: how can interaction with the teacher and fellow students be promoted?

Technological innovations such as home dialysis could significantly improve the quality of life and health of kidney patients. Professor Joris Rotmans therefore wants to continue pushing for new medical technology, as he will explain in his inaugural lecture on 24 March.

What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

On Tuesday 8 April, the CV of Failures exhibition was officially opened by Hester Bijl. Members of the university community share their personal stories during the exhibition. They offer an honest insight into the rejections, setbacks, and unexpected turns that have shaped their journeys.

The €6.24 million EU-funded research project QSPainRelief has kicked off. The project aims to help patients suffering from chronic pain with novel, personalised combinational treatments and is coordinated by Elizabeth de Lange from the Leiden Academic Center for Drug Research.

PhD defence

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

There is currently a disruption that prevents network access.

There is currently a disruption of several network services.

People who have negative expectations about a treatment actually experience more pain. Merve Karacaoglu discovered in her PhD research that anxious and pessimistic individuals are particularly susceptible to this nocebo effect. However, this sensitivity comes with a silver lining.

Exercising less, skipping parties and struggling at work: the expectation of chronic pain and itching can lead to avoidance behaviour. But this is by no means the case for everyone with chronic pain, as PhD candidate Gita Nadinda discovered. What does this mean for healthcare?

eLaw - Center of Law and Digital technologies from Leiden Law School, and the Vascular Surgery Department at Leiden University Medical Centre in the Netherlands, join forces to explore the use of AI for diabetes and secondary prevention of diabetic foot problems and won a prize for it.

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

Human failures or faults in systems are certainly just as harmful as a targeted attack by hackers. That is what Leiden professor in cybersecurity Bibi van den Berg says in the Haarlems Dagblad. She states the recent huge disruptions at Schiphol are interesting examples.

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

M. Danhof, Co-promotor: O.E. Della Pasqua

The Dutch Health and Youth Care Inspectorate (IGJ) has found that foster care at stitching Enver is not up to scratch. Mariëlle Bruning, Professor of Children and the Law, spoke to public broadcaster NOS about these new findings.

Doctorates, scholarships, or a trip around the world during a sabbatical: when it comes to our careers, we often talk about what went well. The CV of Failures exhibition at the Herta Mohr Building shows the other side of the coin. On large boards, university staff talk about rejections, setbacks, and…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

For the next couple of years, Joris van der Voet, Associate Professor and researcher at the Institute for Public Administration will be heading a research project on top-level bureaucrats and how they go about making choices and prioritizing issues. He has been awarded a Vidi grant by the Dutch Research…