Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)

Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…

This project is aimed at 1) elucidating the role of attention in itch and pain, including orientation, and attentional disengagement (i.e., directing attention away) from itch and pain; and 2) modifiability of these attentional processes.

To relieve a patient's pain, it can be effective to induce expectations. This finding is promising for optimising the effectiveness of treatments, conclude Kaya Peerdeman and colleagues in their article in PAIN.

Researchers at Leiden University led by Mario van der Stelt (Leiden Institute for Chemistry) have set ‘gold standards’ for developing new painkillers based on the medicinal effects of cannabis. Publication in Nature Communications.

The Power and Pains of Polysemy: Maritime Trade, Averages, and Institutional Development in the Low Countries (15th–16th Centuries) investigates the development of General Average and other so-called Averages in the Low Countries on the eve of the early modern period, showing how the various varieties…

Shell, our country's largest company, is constructing a vast plastics plant in the United States. And it is doing so at a time when the European Union, led by the Netherlands, is launching a major pact to combat use of plastic.

The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.

If it’s up to PhD student Guangsheng Du, patients don’t need to worry about big needles anymore. At the Leiden Academic Center for Drug Research (LACDR), he studied the use of microneedles and nanoparticles as a new vaccination system. ‘I want to create a more patient-friendly delivery method.’ He defends…

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

Microneedles are a promising tool for the painless administration of vaccines through the skin. But, are these minuscule needles really effective? PhD student Pim Schipper of the Leiden Academic Centre for Drug Research investigated various factors of vaccination via the skin and discovered, among other…

A consortium led by Leiden University has been awarded 6.75 million euros to research traumascapes: physical places associated with collective trauma and loss. The research team aims to make these places more visible, accessible and inclusive.

Wat gebeurt er op het schoolplein? Sensoren op kleding openbaren pijnlijke patronen

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

What role play stress and fear in forming of nocebo hyperalgesia?

Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.

Can we develop a tool to early identify male chicken eggs?

The Leiden Academic Centre for Drug Research (LACDR) received no less than three awards during the Figon Dutch Medicine Days. Bas Goulooze won the PhD Prize for best PhD candidate, Natalia Ortiz Zacarías and Huub Sijben both received a poster prize. ‘Scientists must be able to communicate their research…

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Collecting as much information as possible about administering a new medicine to people can save a lot of money.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

The more we learn about a (neuro-)psychological or physical disorder and the related behavioral factors, the better we can not only identify them, but also treat them. It is therefore important that recent insights about (neuro-)psychological problems and related behavioral factors are incorporated…

Positive expectations can influence sensations of itch and evoke placebo effects, whereas negative expectations can trigger nocebo effects in itch. There is evidence that placebo effects can occur even when people know that they are taking a placebo. Little is known about how these so-called open-label…

We carry a profound responsibility for our research animals and strive to provide them with the best possible quality of life. In our studies, we make every effort to avoid and minimise discomfort for the animals. Below, you can learn more about how this is put into practice.

We aim to conduct as few animal experiments as possible. We are continually exploring methods to Replace, Reduce, and Refine animal experiments, commonly referred to as the three Rs. Additionally, we assess each study to ensure the implementation of the 3Rs has been maximised. The Animal Welfare Body…

Elk jaar organiseert het LIBC in samenwerking met de gemeente Leiden een Publieksdag over hersenonderzoek.

The research connected to this topic is related to Work and health.

Unlike most city histories, this book focuses exclusively on the city’s connections with colonialism and slavery.

In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.

PhD defence

The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

The master's specialisation Health and Medical Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

Make sure you have a suitable place to work or study.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.