Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

A new paramagnetic probe has been synthesized and applied to proteins.

Knots come in all shapes and sizes: mariners and scouts can vouch for this. Sjabbo Schaveling will obtain his PhD on 1 September for a mathematical method to distinguish between all these knots. ‘I flatten them to a pretzel.’

Streptomycetes are similar to moulds, but these bacteria live in the soil. They are very popular in biotechnology because they produce a great many antibiotics and enzymes. Gilles van Wezel will be using his Vici subsidy to study ways of increasing their production.